array(14 items) uid => 938 (integer) title => 'Comparative RNA genomics' (24 chars) abstract => 'Over the last quarter of a century it has become clear that RNA is much more
than just a boring intermediate in protein expression. Ancient RNAs still a
ppear in the core information metabolism and comprise a surprisingly large c
omponent in bacterial gene regulation. A common theme with these types of mo
stly small RNAs is their reliance of conserved secondary structures. Large-s
cale sequencing projects, on the other hand, have profoundly changed our und
erstanding of eukaryotic genomes. Pervasively transcribed, they give rise to
a plethora of large and evolutionarily extremely flexible non-coding RNAs t
hat exert a vastly diverse array of molecule functions. In this chapter we p
rovide a-necessarily incomplete-overview of the current state of comparative
analysis of non-coding RNAs, emphasizing computational approaches as a mean
s to gain a global picture of the modern RNA world.' (887 chars) authors => array(4 items) 0 => array(3 items) last_name => 'Backofen' (8 chars) first_name => 'Rolf' (4 chars) sorting => 1 (integer) 1 => array(3 items) last_name => 'Gorodkin' (8 chars) first_name => 'Jan' (3 chars) sorting => 2 (integer) 2 => array(3 items) last_name => 'Hofacker' (8 chars) first_name => 'Ivo L.' (6 chars) sorting => 3 (integer) 3 => array(3 items) last_name => 'Stadler' (7 chars) first_name => 'Peter Florian' (13 chars) sorting => 4 (integer) type => '0' (1 chars) keywords => '' (0 chars) year => 2024 (integer) affiliation => 0 (integer) link_paper => '' (0 chars) link_supplements => '' (0 chars) file_published => 0 (integer) journal => 'Methods in Molecular Biology' (28 chars) doi => ' 10.1007/978-1-0716-3838-5_12' (29 chars) preprint => '-1' (2 chars)
Comparative RNA genomics
2024: Rolf Backofen; Jan Gorodkin; Ivo L. Hofacker; Peter Florian StadlerIn: Methods in Molecular Biology DOI: 10.1007/978-1-0716-3838-5_12
Over the last quarter of a century it has become clear that RNA is much more than just a boring intermediate in protein expression. Ancient RNAs still appear in the core information metabolism and comprise a surprisingly large component in bacterial gene regulation. A common theme with these types of mostly small RNAs is their reliance of conserved secondary structures. Large-scale sequencing projects, on the other hand, have profoundly changed our understanding of eukaryotic genomes. Pervasively transcribed, they give rise to a plethora of large and evolutionarily extremely flexible non-coding RNAs that exert a vastly diverse array of molecule functions. In this chapter we provide a-necessarily incomplete-overview of the current state of comparative analysis of non-coding RNAs, emphasizing computational approaches as a means to gain a global picture of the modern RNA world.