A
Tale of Cell Biology Told by Budding Yeast (and a Cyanobacterium)
A lecture series beyond the known knowns of (cell) biology, exploring
the known unknows, the unknown
unknowns, and some unknown knowns.
In this lecture series, we will trace a few specific paths through
the vast directed acyclic graph of scientific progress. Is
it a linear and logical process (Karl Popper) or a historical
development, shaped by traditions, big egos and vanity (Ludwik
Fleck)?
Introduction
- Quantitative Microbiology: Exponential growth
is rarely balanced.
Transcription
- Pervasive transcription
during the low energy phase of respiratory oscillations.
- Transcription at LTR retrotransposons and
genome evolution.
Genome Homeostasis
- DNA as a metabolic
sensor, and
- Chromosomal domains, mobile elements and genome
evolution.
Protein Homeostasis
- Protein homeostasis by a
transcriptional oscillator, and
- The pulse-width modulation model of gene
expression.
- Metabolism: feedbacks and the auto-catalytic cycles
of life.
- Do yeast cells dream of metabolic sheep?
or: The
cell growth cycle as a cell-structural
proofreading loop.
Other Species
- Same, same in a cyanobacterium (circadian DNA
supercoiling homeostasis).
- The cell growth cycle in other eukaryotes: circadian and
developmental clocks.
Rainer Machné