Do yeast cells dream of metabolic sheep?

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YRO in Mammalian Systems?

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Rainer Machné

Growth factor-dependent ERK pulses (Albeck, Mills, and Brugge 2013) and multiple growth pulses per division cycles (Liu et al. 2020) in mammalian cells bear analogies to the YRO. Similar periodic phenomena in mammalian systems have a rich but fragmented research history, e.g. Klevecz (1976).

References

Albeck, J. G., G. B. Mills, and J. S. Brugge. 2013. "Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals." Mol Cell 49 (2): 249-61. https://doi.org/10.1016/j.molcel.2012.11.002.
Brodsky, W. Y. 1975. "Protein Synthesis Rhythm." J Theor Biol 55 (1): 167-200.
Klevecz, R. R. 1976. "Quantized Generation Time in Mammalian Cells as an Expression of the Cellular Clock." Proc Natl Acad Sci U S A 73 (11): 4012-16.
Klevecz, R. R., and F. H. Ruddle. 1968. "Cyclic Changes in Enzyme Activity in Synchronized Mammalian Cell Cultures." Science 159 (3815): 634-36.
Liu, X., S. Oh, L. Peshkin, and M. W. Kirschner. 2020. "Computationally Enhanced Quantitative Phase Microscopy Reveals Autonomous Oscillations in Mammalian Cell Growth." Proc Natl Acad Sci U S A, October. https://doi.org/10.1073/pnas.2002152117.