Researcher at Bionformatics, Computer Science Department
University of Leipzig
Härtelstrasse 16-18, Room 448.1
04107 Leipzig, Germany
|Phone||Office: +49 (0) 341 97 16689|
Researcher with Peter Stadler at his Bioinformatics group, Computer Science, University of Leipzig. 2005-2012, "Akademischer Rat" (comparable to "assistant professor") at Rolf Backofen's Bioinformatics group at the University of Freiburg. 2011, Instructor at the Mathematical Department of MIT. 2010-2011, post-doc with Bonnie Berger at the Computation and Artificial Intelligence Lab (CSAIL) at the Massachusetts Institute of Technology (MIT), Cambridge, MA. Research Scholarship by DFG (German Research Foundation). PhD Fellowship of GKLI (PhD programme 'Graduiertenkolleg Logic in Computer Science') of the LMU until move to University of Jena. Computer Science PhD (Dr.rer.nat.) in Jena.
Algorithms for big bio-data. Bioinformatics of RNA and protein structure. Structure prediction, interaction, folding dynamics, and comparative analysis of structural RNA. Genome-wide prediction of non-coding RNA. Dynamic programming and sparsification. Constraint programming.
This publication list in PDF adds first and corresponding author annotations and is broken down into publication categories; also contains my theses.
Algorithms and Data Structures I+II (15/16): organisation of recitation classes, assignments
Theoretical Biology (Summer 16) (w/ P. Stadler)
Graphs and biological networks (Winter 14/15) (Graph Theory; w/ P. Stadler)
Advanced Methods in Bioinformatics (Winter 14/15 and 12/13) (with Peter Stadler)
Class 18.417: Foundations of Structural Bioinformatics, Summer 2011
(as instructor of the MIT Math Department)
Please find a collection of slides from my recent conference talks. Feel free to use the material (but please reference.)
WABI 2015. Sparse RNA folding revisited: space-efficient minimum free energy prediction (update to Benasque'15)
Benasque 2015. SPARSE: Quadratic Time SA&F of RNAs without Sequence-Based Heuristics (update to RECOMB'13)
LocARNA - fast and space-efficient simultaneous folding and alignment of RNAs.
LocARNA is the name-giving tool of the LocARNA package. I am the main developer of this package for structure-based comparison of RNAs (of potentially unknown structure). LocARNA is also accessible online as web server.
SPARSE - very efficient simultaneous folding and alignment of RNAs with strong ensemble-based sparsification (with Milad Miladi)
ExpARNA-P - exact simultaneous folding and pattern matching in RNAs (implemented by Christina Schmiedl as part of the LocARNA package.)
REAPR - Realignment for Prediction of Structural Non-coding RNA. A pipeline for whole genome realignment and de-novo prediction of non-coding RNA candidates (implemented by Michael Yu.)
SparseMFEFold - Very space-efficient RNA structure prediction. Demo implementation for the research paper "Sparse RNA folding revisited: space-efficient minimum free energy prediction".
MEA - prediction of maximum expected accuracy structures of RNAs with penalties for long base pairs. Comparison of structures by F-measure and MCC.
LocARNAscan - scanning variant of the LocARNA-algorithm (implemented by Michael Siebauer.)
LocARNA-P - fast and space-efficient computation of reliabilities for simultaneous folding and alignment of RNAs (with Tejal Joshi).
The tool is accessible online from the LocARNA web server. Please select alignment mode "LocARNA-P (probabilistic)".
CARNA - Constraint-based alignment of RNA Ensembles. CARNA supports many non-standard alignment cases like pseudoknots and multiple stable structures. The tool is available for download (as source code) and accessible online via the CARNA web server.
CTE-Alignment - Efficient Sequence Alignment with Side Constraints by Cluster Tree Elimination.
PSP - Protein structure prediction in HP-type models (using Constraint Programming). The original software, written for Mozart/Oz in the course of my Master's Thesis, is superseeded by the C++/Gecode implementation CPSP Tools of Martin Mann.