Andreas Schwienhorst, Andreas Schober, Rolf Guenther, and Peter F. Stadler

Synthesis of random libraries of polynucleotide sequences has become a standard procedure of biotechnology; in combination with amplification methods such as the polymerase chain reaction (PCR) [1] this allows for selection experiments in which large pools of sequences are screened for a desired function. Provided the desired function can be used to design a selection consistraint, these basic techniques can be combined in elegant in vitro experiments consiting of alternate cycles of selection and amplification of the selected function.

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