95-10-090
Abstract:
Hamming-Chromatography
Andreas Schwienhorst, Andreas Schober, Rolf Guenther, and
Peter F. Stadler
Synthesis of random libraries of polynucleotide sequences has become
a standard procedure of biotechnology; in combination with amplification
methods such as the polymerase chain reaction (PCR) [1] this allows for
selection experiments in which large pools of sequences are screened
for a desired function. Provided the desired function can be used
to design a selection consistraint, these basic techniques can be
combined in elegant in vitro experiments consiting of alternate
cycles of selection and amplification of the selected function.
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