Since January 2009 I'm working on this project at TRM-Leipzig. One question there is, when do cells turn into functional tissue. It goes along with things like cell-division and differentiation. Currently we are studying chemical models for the cell-cycle.

In cooperation with the Department of Dermatology and Venereology of the University Leipzig we are working on 3D-reconstructions of a common form of skin-cancer. The base of this work are stained serial sections which are then processed through different registration and segmentation steps to obtain the reconstructed tumour inside.

Here you can see the effect of an rigid registration on a small sample stack of slides. The images are only rotated and translated not transformed non-linear.

In every slide the tumorous part is selected with a colour-segmentation method. A segmentation divides an image into different (often but not always non-overlapping) classes according to the colour.

The last step is to put all segmentation results together and build the reconstruction.

This is ongoing work and the results will be published. This research partially bases on the following work: