Publications - Published papers

Please find below publications of our group. Currently, we list 500 papers. Some of the publications are in collaboration with the group of Sonja Prohaska and are also listed in the publication list for her individual group. Access to published papers (access) is restricted to our local network and chosen collaborators. If you have problems accessing electronic information, please let us know:

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U6 snRNA Intron Insertion Occurred Multiple Times During Fungi Evolution

Sebastian Canzler, Jana Hertel, Peter F. Stadler

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RNA biology 13.2 (2016): 119-127

Abstract


U6 small nuclear RNAs are part of the splicing machinery. They exhibit several unique features setting them apart from other snRNAs. Reports of introns in structured non-coding RNAs have been very rare. U6 genes, however, were found to be interrupted by an intron in several Schizosaccharomyces species and in two Basidiomycota. We conducted a homology search across all 147 currently available fungal genome and identified the U6 genes in all but two of them. A detailed comparison of their sequences and predicted secondary structures showed that intron insertion events in the U6 snRNA were much more common in the fungal lineage than previously thought. Their positional distribution across the entire mature snRNA strongly suggests a large number of independent events. All the intron sequences reported here show canonical splice site and branch site motifs indicating that they require the spliceosomal pathway for their removal.

Keywords


snRNA,Fungi,snRNAevolution,homologysearch,intron