Publications - Published papers

Please find below publications of our group. Currently, we list 496 papers. Some of the publications are in collaboration with the group of Sonja Prohaska and are also listed in the publication list for her individual group. Access to published papers (access) is restricted to our local network and chosen collaborators. If you have problems accessing electronic information, please let us know:

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Impact of individual nodes in Boolean network dynamics

Fakhteh Ghanbarnejad, Konstantin Klemm

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Europhysics Letters 99:58006 (2012)

Abstract


Boolean networks serve as discrete models of regulation and signaling in biological cells. Identifying the key controllers of such processes is important for understanding the dynamical systems and planning further analysis. Here we quantify the dynamical impact of a node as the probability of damage spreading after switching the node's state. We find that the leading eigenvector of the adjacency matrix is a good predictor of dynamical impact in the case of long-term spreading. This so-called eigenvector centrality is also a good proxy measure of the influence a node's initial state has on the attractor the system eventually arrives at. Quality of prediction is further improved when eigenvector centrality is based on the weighted matrix of activities rather than the unweighted adjacency matrix. Simulations are performed with ensembles of random Boolean networks and a Boolean model of signaling in fibroblasts. The findings are supported by analytic arguments from a linear approximation of damage spreading.

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http://arxiv.org/abs/1111.5334