Publications - Published papers

Please find below publications of our group. Currently, we list 511 papers. Some of the publications are in collaboration with the group of Sonja Prohaska and are also listed in the publication list for her individual group. Access to published papers (access) is restricted to our local network and chosen collaborators. If you have problems accessing electronic information, please let us know:

©NOTICE: All papers are copyrighted by the authors; If you would like to use all or a portion of any paper, please contact the author.

Evolution of the let-7 microRNA Family

Jana Hertel, Sebastian Bartschat, Axel Wintsche, Christian Otto, The Students of the Bioinformatics Computer Lab 2011, Peter F Stadler


PREPRINT 11-022:   [ Supplement ]
[ Publishers's page ]  paperID


RNA Biology 9: 231-241 (2012)


The increase of bodyplan complexity in early bilaterian evolution is intimately linked with the advent and diversification of microRNAs. These small RNAs guide animal development by regulating temporal transitions in gene expression involved in cell fate choices and transitions between pluripotency and differentiation. One of the two known microRNAs whose origins date back before the bilaterian ancestor is mir-100. In bilateria it appears stably associated in polycistronic transcripts with let-7 and mir-125, two key regulators of development. In vertebrates, these three microRNA families have expanded to form a complex system of developmental regulators. In this contribution we disentangle the evolutionary history of the let-7 locus, which was restructured independently in nematodes, platyhelminths and deuterostomes. The foundation of a second let-7 locus in the common ancestor of vertebrates and urochordates predates the vertebrate-specific genome duplications, which then caused a rapid expansion of let-7 family.


micro RNA, let-7, mir-100, mir-125, miRNA evolution