Publications - Published papers

Please find below publications of our group. Currently, we list 500 papers. Some of the publications are in collaboration with the group of Sonja Prohaska and are also listed in the publication list for her individual group. Access to published papers (access) is restricted to our local network and chosen collaborators. If you have problems accessing electronic information, please let us know:

©NOTICE: All papers are copyrighted by the authors; If you would like to use all or a portion of any paper, please contact the author.

Evidence for Human microRNA-Offset RNAs in Small RNA Sequencing Data

David Langenberger, Clara Bermudez-Santana, Jana Hertel, Philipp Khaitovich, Steve Hoffmann, Peter F. Stadler

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Bioinformatics. 2009 Sep 15;25(18):2298-301.

Abstract


MicroRNA-offset-RNAs (moRNAs) were recently detected as highly abundant class of small RNAs in a basal chordate. Using short read sequencing data we show here that moRNAs are also produced from human microRNA precursors, albeit at quite low expression levels. The expression levels of moRNAs are unrelated to those of the associated microRNAs. Surprisingly, microRNA precursors that also show moRNAs are typically evolutionarily old, comprising more than half of the miRNA families that were present in early Bilateria, while evidence for moRNAs was found only for a relative small fraction of miRNA families of recent origin.