Publications - Published papers

Please find below publications of our group. Currently, we list 508 papers. Some of the publications are in collaboration with the group of Sonja Prohaska and are also listed in the publication list for her individual group. Access to published papers (access) is restricted to our local network and chosen collaborators. If you have problems accessing electronic information, please let us know:

©NOTICE: All papers are copyrighted by the authors; If you would like to use all or a portion of any paper, please contact the author.

U7 snRNAs: A Computational Survey

Manja Marz, Axel Mosig, Bärbel M. R. Stadler, Peter F. Stadler

Download


PREPRINT 07-010: [ PDF ]  [ Supplement ]
[ Publishers's page ]  paperID

Status:


Geno.Prot.Bioinf. 5: 187-195 (2007)

Abstract


U7 snRNA sequences have been described only for a handful of animal species in the past. Here we describe a computational search for functional U7 snRNA genes throughout vertebrates which included the upstream sequence elements characteristic for snRNAs transcribed by pol-II. Based on the results of this search, we discuss the high variability of U7 snRNAs in both sequence and structure and we report on an attempt to find U7 snRNA sequences in basal deuterostomes and non-Drosohilid insect genomes based on a combination of sequence, structure, and promoter features. Due to the extremely short sequence and the high variability in both sequence and structure, no unambigous candidates were found. These results cast doubt on putative U7 homologs in even more distant organisms which are reported in the most recent release of the Rfam database.

Keywords


U7 snRNA, Noncoding RNA, RNA Secondary Structure, evolution