Publications - Published papers

Please find below publications of our group. Currently, we list 508 papers. Some of the publications are in collaboration with the group of Sonja Prohaska and are also listed in the publication list for her individual group. Access to published papers (access) is restricted to our local network and chosen collaborators. If you have problems accessing electronic information, please let us know:

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Evolution of the Vertebrate Parahox Clusters

Sonja J. Prohaska, Peter F. Stadler

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J. Exp. Zool.: Mol. Dev. Evol. 306B: 481-487 (2006).

Abstract


<b>Motivation:</b><br/> The ParaHox cluster contains three <i>Hox</i>-related homeobox genes. The evolution of this sister of the <i>Hox</i>-gene clusters has been studied extensively in metazoans with a focus on its early evolution. Its fate within the vertebrate lineage, and in particular following the teleost-specific genome duplication, however, has not received much attention.<br/> <b>Results:</b><br/> Three of the four human ParaHox loci are linked with PDGFR family tyrosine kinases. We demonstrate that these loci arose duplications in an ancestral vertebrate and trace the subsequent histroy of gene losses. Surprisingly, teleost fishes have not expanded their ParaHox repertoire following the teleost-specific genome duplication, while duplicates of the associated tyrosine kinases have survived, supporting the hypothesis of a large scale duplication followed by extensive gene loss.

Keywords


ParaHox, cdx, xlox, gsx, tyrosine receptor kinases, PDGFR, VEGFR genome duplication