Publications - Published papers

Please find below publications of our group. Currently, we list 508 papers. Some of the publications are in collaboration with the group of Sonja Prohaska and are also listed in the publication list for her individual group. Access to published papers (access) is restricted to our local network and chosen collaborators. If you have problems accessing electronic information, please let us know:

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Evolving Towards the Hypercycle: A Spatial Model of Molecular Evolution

Camille Stephan-Otto Attolini, Peter F. Stadler

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Physica D 217: 143-141 (2006).

Abstract


We extend earlier cellular automata models of spatially extended hypercycles by including an explicit genetic component into the model. This allows us to study the sequence evolution of hypercyclically coupled molecular replicators in addition to considering their population dynamics and spatial organization. In line with previous models, that considered either spatial organization or sequence evolution alone, we find both temporal oscillations of the relative concentration of the species forming the hypercycles as well as the formation of spatial organisations including spiral waves. We also confirm the greatly increased robustness of the spatially extended hypercycle against various classes of parasites. We find the sequence evolution of each of the hypercyclically coupled populations proceeds (after an inital selection-dominated phase) in a drift-like manner that can be described by a diffusion process in sequence space. Kimura's theory of neutral evolution is therefore applicable on long time-scales despite the fact that the hypercycle exhibits extreme periodic changes in population sizes and that are governed solely by frequency-dependent selection.

Keywords


Quasispecies, hypercycle, cellular automata, RNA secondary structure