CLUSTAL W (1.83) multiple sequence alignment Hox1 MEQMDT-----ARMNSY-VDYSLCNG-DQ-NTCSP-R---SYGQDY-GVPAYQSCA---M Hox2 MDAPR--------ESGF-IN-SHPSL-EEFMSCLP-I---S------------------- Hox3 MQKSP------YYETTSQ---QLYNGY-SY----S------NGERFGYE-GS---G---- Hox4 MIMSS------FLMNSGYVDPKFPPVE-EY----S------Q---NSYI-PS---Q---- Hox5 MSS--------YFVNSYP-A-RYQNGQ-DF----Q------VGS-FS---SS---R---- Hox6 MSS--------YFVNSFA-G-NLQNGGDTY----P------AGQGY---PVR-------Y Hox7 MSS--------YFVNSLL-T-KYQPGE-SL----S------SSNGFAGVPSC---S---Y Hox8 MSS--------YLNNTM-----YQRG-ETF----P------HA-GV---NST---V---- Hox9 MMTSGT--ANPYFVDSLI-T-NV--GE-DV--FKG-R---GDDPRL-GLPLWR--R---- Hox10 MTSSSPI-AGGFLLDAYI-S-G------------------GSANLY-GRPGLCMT----- Hox11 MDG--------YWLQPFH-D-LK-----------P-R---GETGGW-HLPGLCMPK---- Hox12 MSY--------IHYNGTA-------------------------G----FSSLCTA----- Hox13 MVDMRNCLHSPSKPS------DAHKGV-AP----R-----PNTLTF-ARQT--AS-VVNF Hox14 METATGI-NGPLW---------APTGY-SI----S---SMQDTNFW-SRG---GS-EMAY Hox15 MSGIAGAE-TDLLPRSWG---GLNGGC-KP----LPGQGTPHSNTY-TVQSSALSRDSVY * Hox1 N-N-----------VD-RHVT---------M-GPS-------------GQL----PPSAG Hox2 ------------------------------------------------------------ Hox3 --------------------------------------------------G----GGSYG Hox4 --------------------------------------------------I----PDYYG Hox5 G-S-----------------G-----------SAG-------------PYG----GGSAG Hox6 D-----------------------------P-MR---------------QY----PTPYG Hox7 G-E-----------LA----S---------T-ARG-------------GYH----AGAYG Hox8 G-N------------------------------HH-------------PYY----SSWYG Hox9 G-NGGQASGF--PNCS-Y--S---------S-SAG----ASF------YYHQ---SPER- Hox10 G-NGALD-SAHWQPCARI--P---------PTSDG----HNA------RALSSSLSPHDA Hox11 G-E-AHADGLRLGPLG-Y--P---------C-REG----KDM------NLTD----T--- Hox12 ------------------------------------------------------------ Hox13 GAME----------------SYT-------GYHSQ----------------------FLG Hox14 G-DR-----------------LP-------P-RRD----------------------FFM Hox15 A-RD-----------------LPVPLLMMPA-RKDVSHGASNMGWNASSHH----LHMAQ Hox1 PG--PGPVP-----GPSPY-DP-PVI---MSNGDPQNFTTYSYNHYS---------HPG- Hox2 ------------------A-DF-------------------------------------- Hox3 T----------------------D--------------V--------------------- Hox4 S----------------------PSP--Q---------R--------------------- Hox5 ME--PAA-A-----AAYDY-SY-PRQ--QQQQQQPQQQP-----QQS---------QPS- Hox6 P----------------------PER-----------FP--------------------- Hox7 P------------------------------------YP--------------------- Hox8 Y----------------------PAA--N--------FR------TD------------- Hox9 -------------SNTVSC--L-YPY----------LP-----PRHL---------PNDG Hox10 PW--PGITGGYYGTQAVDY--T-PSA----------I------DHYS---------LSSG Hox11 ----------------RRI--L-PST----------FH-----PFYD---------VSAG Hox12 ----------------HRM--F-PSP-----------T-----WLYG---------QRYL Hox13 P--GPG-----------PY-DS-RQAMGQTLNQCPCQGC-----SL----RWQQTPQPA- Hox14 S--GPA-----------------------TSTT-----C-----TYSQNVRLVEGPHR-- Hox15 ECPAPIA----------EYYTPGEQTYQPVGFALPQ----------SRGCD----PF--- Hox1 ---------------------------------GH-HM-------------------GNG Hox2 ------------------------------------------------------------ Hox3 -----------------------------------TQEFGPSCS--------VR-K---- Hox4 -----------------------------------AQNYGPTAY--------QR-A---T Hox5 ---------------------------------QPHHQTQSDCT--------LT-RG--- Hox6 -----------------------------------VYSTGDGTL--------Y-GAQQGA Hox7 -----------------------------------ATNSGPRDF--------YNGGAAAG Hox8 -----------------------------------RDNVSPTCT--------YA-AAAA- Hox9 ----------------------------------TD------------------GINPWT Hox10 IKRETHFRAKSASERFGCGQDSMMAQFFPMERKLPH------HT--------DYNYLRYQ Hox11 ----------------------------------AH------------------------ Hox12 ----------------------------------YH-------------------QFQEG Hox13 ---------------------------------GPHNN--ALCPPYSSYDHSL------L Hox14 ---------------------------------APHHS---------PDKYSQ------- Hox15 ----------------------------------PNGH--EYCPPGYAVDAQY------- Hox1 YGTN---N----HAAMYSGSFGAELAGS-------YSSY----NSGM----NG-TVAPP- Hox2 -------------------------LES-------SITV----ETAE----DG-RTWPA- Hox3 -------------------------------------------QGSSAGGGTG-NVSPT- Hox4 YAETT-YN----HVSQAAR----------------NVPPPQPSHGQAPGPGPG-PETPP- Hox5 -DTPH-QQ----QSACAQS----SMGGGGQTQRLTHLPMSTPAMSPA-----T-CTSP-- Hox6 YPDPI-KH----EAALASH----------------HLPQYSSCKLQA-----N-SPSP-- Hox7 YGSPN-AH----Y---Q-E----------------SPPVSSYCRGSA-----E-SASP-- Hox8 ----V-VN----HGQVQDS----------------QTPENC-CWNGQ-----D-QGAP-- Hox9 EPVPN-NH----QAA-GSS----YCNGTGLHATA--MQVYKTSD-------AE--AGKT- Hox10 YGSNNKDY----HKL-SNS----THGGGGTTAPS--AGIFAATE--KHGGGLGQWSAPA- Hox11 HRD---------QIA-----------RAQLHNTA--AYDSKCCQ-------PQ--MNN-- Hox12 -------H------------------SANLENEK--RLQVGLCP-------TG--IER-- Hox13 KPTWN-NQAKDFGPIF---------SGS-------N------FSQNF----GG-QSYPVP Hox14 ------------------------------------------VDFPR----DE-PFQPV- Hox15 ------------GCRY---------Y--------------------------D-QRSPVN Hox1 -PLDSQYGY-----MHHH-------------------------TGQDPMIS--------- Hox2 -LHPTTCL--------------------------------------EL------------ Hox3 ----CMKT--------------NPPDNNHSS----PPQ------------S--------- Hox4 --PHSRPTSTLSTVQHNHN--VSPPAPSQPTPPPPPPA-----TSTTAAST--------- Hox5 --PSSTGMAT------------HPASQNTPSP----PDVDLES-VGSPNAT--------- Hox6 --LPSA--------------------------------------QGSPGST--------- Hox7 --PQSMSAMH------------GAACSYQQAE----VRKDMAGVGGHPGHP--------- Hox8 --AGMQQQR--------------PSCQ----------------QEEKPATM--------- Hox9 -T---AG--------------TGPPGYTGY---------------SQPYRDMHAQGLSLD Hox10 -G---PT--------------TGPVGNSNF-----------SGADSHPNTA--------- Hox11 -----VC--------------TYTSASSSD---------------R-----TEQVSQAWD Hox12 -----------------------------------------------------------S Hox13 DGLNKPSGV-----RENCTVGTLDPASSS-L----PPC------------R--------- Hox14 ---------------------VLPPASGPLH----PPF------------T--------- Hox15 --------------QSMYGAQQLHPTTNS-S----PPK------------A--------- Hox1 ----T---------S----CNPPAPSP--PVATYDWMKLKRNPPRTGKPG---------- Hox2 --------------N----SDLSAARP-ANIADFPWVKLKKSV-RTQSPVFNTQ-EA-DA Hox3 ----V--------SNA--------SIL-ANTKIYPWMKESRQNSKQRQPTNLSVGTT-ET Hox4 ----V--------SDGSPPS---NGPP-TVPMVYPWMKKVHS----------------NT Hox5 ----ATAAGSVQPSNNNTANNTASTSP-SNIPMYPWMRKIHL------------------ Hox6 ----V--------GA--------QLPQ-PTPPVFPWMRKGSS------------------ Hox7 ----V--------QQANPAL---NTAQ-MTTPIYPWMRS--------------------- Hox8 ----G--------M----A----QQSQ-LAIPFYPWMRT--------------------- Hox9 GQMKVKSE-QESPKNGDDKHG--S-AL---ANQPGWM----------------------- Hox10 ------CSTPPASIP-SSTNG--ASPLHV-CGATSWM----------------------- Hox11 GQGCQPAEGPPTPAQGN------S-TG---DvTSNWM----------------------- Hox12 GS--EDSGCPKDSKKGDTADG--SEAD-P-NGTDVWW----------------------- Hox13 ----Y--------SVA--------GPS---QNL----GLPAS----KNVA-----DGPVV Hox14 ----Y--------SPQ--------LCQ-LDHFLESWQRSREA----TKPA-----ETIAH Hox15 ----A--------TVY----------T-QALTAFPGT-NPV-----TGGT-----KGFTT Hox1 --EYGFTTSGPNNGRTNFTTKQLTELEKEFHYNKYLTRARRVEIAAALNLNETQVKIWFQ Hox2 FNSPTDRESSSRRLRTVFTNTQLLELEKEFHYNKYVCKPRRKEIASFLDLNERQVKIWFQ Hox3 GESPGLGGAAAKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMAAMLNLTERQIKIWFQ Hox4 G-STSYNGQDTKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHSLGLTERQIKIWFQ Hox5 --NHSAGTGDNKRTRTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQ Hox6 --Q-TAMGEEKKRGRQTYTRYQTLELEKEFHFNKYLTRKRRIEIAHLLGLTERQIKIWFQ Hox7 ------TAPERKRGRQTYTRYQTLELEKEFHFNKYLTRRRRIEIAHALCLTERQIKIWFQ Hox8 ------AGPERRRGRQTYSRYQTLELEKEFHFNKYLTRRRRIEIAHALGLTERQIKIWFQ Hox9 ------NNHSSRKKRCPYTRFQTLELEKEFLYNMYLTRERRYEISQHVNLSERQVKIWFQ Hox10 ------APRVGRKKRCPYTKYQILELEKEFLFNMYVSRERRQEISRHVNLSDRQVKIWFQ Hox11 ------SAKSTRKKRCPYTKYQTLELEKEFLFNMFVTRERRQEIARQLnltdrqvkiwfq Hox12 ------KLQSSRKKRCPYSKVQLLELEKEFLYNMYITREQRGEIARKVNLTDRQVKIWFQ Hox13 AAADQSVARGGRKKRCPYSKYQLSVLEQEYIQNRYVSRETRLELSQRLNLTDRQVKIWFQ Hox14 QNGGGSLTKPVRPKRRPYSKYQLNELENEYVQNQYISRDKRLQLSQKLNLTERQVKIWFQ Hox15 TAGTTTQRPRTRKKRRPYSKPQLALLEDEYASQKFLTKEKRKEISESSSLSERQVMIWFQ . * :: * **.*: : :: : * ::: *.: *: **** Hox1 NRRMKQKKREKENGFSTPGSG----G---------------------------------- Hox2 NRRMRQKRRDTKSRSEIGNDLEATAA----------------------PA---DG----- Hox3 NRRMKYKKEQKVKGGGSGG--GSGGMNSPSPPLTTTPPGVNPGPHPTTQSSLSQGNNMSS Hox4 NRRMKWKKDNRLPNTKTRSSSASGGSG-PA-----------------VNSTV-------- Hox5 NRRMKWKKENKLKSLSQCQ----------------------------------------- Hox6 NRRMKWKKENKIPSLNATTINQLTNM---N------------------------------ Hox7 NRRMKWKKENKLESLKQQP----------------------------------------- Hox8 NRRMKLKKEAAMLCPPKVEETEK------------------------------------- Hox9 NRRMKMKKMSKQRQEQQ------------------------------------------- Hox10 NRRMKMKRMNKAREEQIRNHQE-------------------------------------- Hox11 nrrmkmkrmkqr------------------------------------------------ Hox12 NRRMKMKRMKQRHEEEAFRAHT-------------------------------------- Hox13 NRRMKQKRLEFRSG---------------------------------------------- Hox14 NRRIKQKKLDRRNSE--------------------------------------------- Hox15 NRRMKEKKLARRAAAQR------------------------------------------- ***:: *: Hox1 ------------------------------------------------------------ Hox2 --------E--------------------------------------------------- Hox3 HMSMMGSLQQTQPSYSQYPPPHLNHSLPHQAPPHSVGITMSGPVSPQCYQANHSPCPPTS Hox4 ------------------------------------------------------------ Hox5 ------------------------------------------------------------ Hox6 ------------------------------------------------------------ Hox7 ------------------------------------------------------------ Hox8 ------------------------------------------------------------ Hox9 ------------------------------------------------------------ Hox10 ------------------------------------------------------------ Hox11 ------------------------------------------------------------ Hox12 ------------------------------------------------------------ Hox13 ------------------------------------------------------------ Hox14 ------------------------------------------------------------ Hox15 ------------------------------------------------------------ Hox1 ------------------------------------------------------------ Hox2 ------------------------------------------------------------ Hox3 APHPVPMGNHVPHPRQGPPHMSNGLPASPLEVVSQRQYTPPAAPGPSPTGPGPGHHGLPN Hox4 ----------------------------------VR------------------------ Hox5 ------------------------------------------------------------ Hox6 ------------------------------------------------------------ Hox7 ------------------------------------------------------------ Hox8 ------------------------------------------------------------ Hox9 ------------------------------------------------------------ Hox10 ------------------------------------------------------------ Hox11 ------------------------------------------------------------ Hox12 ------------------------------------------------------------ Hox13 ------------------------------------------------------------ Hox14 ------------------------------------------------------------ Hox15 ------------------------------------------------------------ Hox1 ------------------------------------S-PAG-EDSPSKST Hox2 -------------------------------RAEEGSPGGGTVACPRPQG Hox3 SYPECPPHHTELPHHQYTTPMSVVNMNYCVNVQTQGN-RLN-SAPKLTHL Hox4 --------HN---------------------HHGVTQ-GMV-SDHGMIEL Hox5 ----------------------------------------Q-TQGLNPEH Hox6 -------------------------------SHNNGV-NSD-SDKDLDIK Hox7 ---------------------------------------AE-SETSSTTS Hox8 ------------------------------------S-SDG-QSEKSEEV Hox9 --------------------------------------------QPNPPQ Hox10 --------------------------------------RGH-QAVAPVSG Hox11 ------------------------------------------------am Hox12 ----------------------------------------G-TGLDTDLN Hox13 -----------------------------------------------NQT Hox14 -----------------------------------------------MCP Hox15 -------------------------------------------HAQHLYA