CLUSTAL 2.0.9 multiple sequence alignment D_sechellia ------------------------------------------------------------ D_simulans ------------------------------------------------------------ D_erecta ------------------------------------------------------------ D_yakuba ------------------------------------------------------------ D_melanogaster ------------------------------------------------------------ D_ananassae ------------------------------------------------------------ D_persimilis ------------------------------------------------------------ D_pseudoobscura ------------------------------------------------------------ D_willistoni ------------------------------------------------------------ D_grimshawi ------------------------------------------------------------ D_virilis ------------------------------------------------------------ D_mojavensis ------------------------------------------------------------ Bombyx ------------------------------------------------------------ Phlebotomus ------------------------------------------------------------ Anopheles ------------------------------------------------------------ Aedes ------------------------------------------------------------ Culex ------------------------------------------------------------ Nasonia_vitripennis ------------------------------------------------------------ Nasonia_girault ------------------------------------------------------------ Apis ------------------------------------------------------------ Acyrthosiphon ------------------------------------------------------------ Tribolium ---------------------------------------------------MAHKSSHGP Pediculus ------------------------------------------------------------ Crassostrea ------------------------------------------------------------ Lottia ------------------------------------------------------------ Brugia ------------------------------------------------------------ Ascaris ------------------------------------------------------------ Ancyclostoma ------------------------------------------------------------ Haemonchus ------------------------------------------------------------ C_elegans ------------------------------------------------------------ C_remanei ------------------------------------------------------------ C_brenneri ------------------------------------------------------------ C_briggsae ------------------------------------------------------------ C_japonica ------------------------------------------------------------ Ixodes KGVRATEIIEVIRIYANKDRKRVETVASRIGTTFWSARSGGDKTHQTGRRTGSERISALH Trichinella ------------------------------------------------------------ Capitella ------------------------------------------------------------ Aplysia ------------------------------------------------------------ D_sechellia ----------------------------------------------------------CH D_simulans -----------------------------------------------------------H D_erecta ------------------------------------------------------------ D_yakuba ------------------------------------------------------------ D_melanogaster ------------------------------------------------------------ D_ananassae ------------------------------------------------------------ D_persimilis ------------------------------------------------------------ D_pseudoobscura ------------------------------------------------------------ D_willistoni ------------------------------------------------------------ D_grimshawi ------------------------------------------------ATMATILLVDID D_virilis ------------------------------------------------------------ D_mojavensis ------------------------------------------------------------ Bombyx ------------------------------------------------------LTEKKV Phlebotomus -----------------------------------------------------TVGPDSR Anopheles ---------------MSIENSMETAESMAFTRQCDEVDALPSQTAQSSGSCEPNVVGSSS Aedes -------------------------------RRFSAVHER----SKPATAVESEMIGTAA Culex -------------------------------------------------MSAKNIENTSE Nasonia_vitripennis --SAAAALRHASFGFFSPMQLRWLQQVGNLEIYSRRSFSNMRRFSIVRISLSELFDRGSV Nasonia_girault ------------------------------------------------------------ Apis -MSACITANRRILVNIINMENHDVKTVMEKVSDGIDKVHDVKGVQAEPTPAASSLSLPVS Acyrthosiphon ------------------------------------------------------------ Tribolium SPNGRISLLCAPVGKQTNCATRKWRFLSSRVHLVVRSRRECFQTTALFEPFDGLIAPKRS Pediculus ---------------------------------------IIMSASEKIETTDVAIDNKLT Crassostrea ------------------------------------------------TISTLTLKKKNF Lottia ------------------------------------------------QFSMMTMAESLM Brugia ----------------------MTATVVDQPDKQQNQQQDQEHTSKQHLSEQLQPEHDII Ascaris ------------------------------------------------------------ Ancyclostoma --------------------------------------------------GVRREKGDHV Haemonchus -------------------------------------------------------SFDKA C_elegans ------------------------------------------------------------ C_remanei ------------------------------------------------------------ C_brenneri ------------------------------------------------------------ C_briggsae ------------------------------------------------------------ C_japonica ------------------------------------------------------------ Ixodes ARVCAWCRDRCSGVSICSILSAFISHVRSCPTTSPLDWDTFTVSWDRVMGEVEVLNPSLA Trichinella ------------------------------------------------------------ Capitella ------------------------------------------------RIRATLLLEGFI Aplysia ------------------------------------------------------------ D_sechellia CSVQSCIFEYFGGSNLNLVVLLFPECGSQQRPLDGGGGGGG------------------- D_simulans CSVQSCIFEYFGGSNLNLFVLLFPESGSQQRPLDGGGGGGGSGGGGGG------------ D_erecta -------------FNLNLVVFLLSESGSQQRPLDGGGGGGGSG----------------- D_yakuba -----------------MAEAVKNESGSQQRPLDGGGGGGGGS----------------- D_melanogaster ------MAEAVKNGKNRHSGSAEKESGSQQRPLDSGGGGGASGGGGVA------------ D_ananassae LASIAGFWRPNLKLWRLYQLSSFSDSTSQQRPLDGGGGGGGSGAG--S------------ D_persimilis --------------VTVFDSNFLSESKSQ-RPLDGGGGGGGSGSGGPA------------ D_pseudoobscura -----------------MAEAVKTESKSQ-RPLDGGGGGGGSGSGGPA------------ D_willistoni --------------IALYCLFVVSESSTQ-RPLDGGGGRHIS------------------ D_grimshawi SISLLRCCCFPTHRVVFCDKFSAVMSNIRMQQIKCDCFVAESA----------------- D_virilis ---------------IKCNKYALFY-------------IVESA----------------- D_mojavensis ---------------FRFIVFK----------------ESSQG----------------- Bombyx LLINYCFLMDADNLIIEDGEPTQSPVVGAPSIVEKQKPAS-------------------- Phlebotomus DQVGASVLVSPE--VSGNAEGVAAVAEGASGGGNQASGGS-------------------- Anopheles SAATVGAMVAPAATANDGGASVAAGEDGGRRPLDDDGRRSGGLVSRQDSNELSEANRDGK Aedes AALHV----APERTNNTSGETRTNTAPTATMSVDENDSASGNFAASS-----TAGIDDGL Culex NRNFLASQNDVEPAQSATAAVTAAETTGALQAVPERTTNTSASAPPAT----TTKMDEAA Nasonia_vitripennis LLYHRSTKTNVP---LLFDFQRLKPFIRTCTKFESGSGSGDQDGMISM------------ Nasonia_girault -----STKTNVP---LLFDFQRLKPFIRTCTKFESGSGSGDQDGMISM------------ Apis EQVSLSTGENINKNNYINKKTCSKLLIKNSGKFESGSGSGDQEGGQ-H------------ Acyrthosiphon -----------------------------------GPGTLDH------------------ Tribolium QTVKMSEKSSENGPENPDGKTPATLPQGDVVQQKDARAPTRNEPKP-K------------ Pediculus IRETDDVNSEVVPSVDSDRNSSDWNLPASLTKFRENNHRRKRPRRKSK------------ Crassostrea HSTSDSASVLRE-NGSPRECQQRKDTRAEPLGIENNNEVQEGSESE-------------- Lottia VEIPGGEEMKAEEKNISFGGENTSDVSVSPSDEDRKNGVNGAEHYS-------------- Brugia IASMEGTDDEVAVAVLRDISTDESYQTTVENDPKNEQNYSGRIPDHGV------------ Ascaris ------------------------------------------------------------ Ancyclostoma FTATRVGTRSEARIEVYSAMASKELPSVARPD-DHERSISD------------------- Haemonchus LCEN-----------SHSAMTLSERPTVVPHTSDQERSVSD------------------- C_elegans -------------------MADYYGLFTSD-----TRSVSD------------------- C_remanei -------------------MADYYGLFASE-----ARSVSD------------------- C_brenneri -------------------MADYYGLLASET----ARSLSD------------------- C_briggsae -------------------MAAESSSDNFELS---ARSVSD------------------- C_japonica -------------------MAEMPAR---------SMSASD------------------- Ixodes VVGGAPSTGEEQTTGSATAAGSAPRSVAAPPSEGSANCVGDRDQLIAE------------ Trichinella ----------------------SSNVVEQPAGVMISSLRRQ------------------- Capitella SLCKLCVYMAAIGGSTDGVSMAAEESEGPAQEVRDLEGPSQNGESCSS------------ Aplysia -----------------VRNPRARRGGACSHGSRRHKGGSR------------------- D_sechellia ------------------------GGCGAGMPKRKHRRGK-KSKMQPKK-TKNHYPQWKL D_simulans ------------------------GGCGAGMPKRKHRRGK-KSKMQPKK-TKNHYPQWKL D_erecta ------------------------GGGGAGMPKRKHRRGK-KSKMLPKK-TKNHYPQWKL D_yakuba ------------------------GGGGAGMPKRKHRRGK-KSKMLPKK-TKNHYPQWKL D_melanogaster ------------------------VGGGSGMPKRKHRRGK-KSKMQPKK-TKNHYPQWKL D_ananassae ------------------------GGGGGGIPKRKHRRGK-KSKMLPKK-TKNQYPQWKL D_persimilis ------------------------IGNHNSMPKRKHRRGK-KSKMVPKK-TKNQCPQWKL D_pseudoobscura ------------------------IGNHNSMPKRKHRRGK-KSKMVPKK-TKNQYPQWKL D_willistoni -----------------------------AMPKRKHRRGK-KSKMVPKQNNKNHGPSWKL D_grimshawi --------------------------QSVASQRRKHRRGK-KSKLLPKK-TKNQYPPWKM D_virilis --------------------------QSGASQRRKHRRGK-KSKMLPKK-TKNQYPPWKM D_mojavensis --------------------------VPGATQRRKHRRGK-KSKMLPKK-TKNQYPPWKM Bombyx ---------------------------VDGNVKKKRRRANTKRKVMTPFVKAPWRDRRRN Phlebotomus ---------------------------ERPKGKRKCRRGRAKAKRNNTHVKP-----YAW Anopheles GHPGVGSNQGNGTGVPMATAATMSNRTGEGRCRRKNRRRKSNRGK-SSSNRPYSKTQWKF Aedes AAMSPGSGRGGGRRTTITEQG--SDGSDKNNSKRKTRRGKTKRGKRSSSARPYSKSQWKY Culex GIARSSSSGGGGPNE---------KRRSNDGAKRKTRRGKAKRGKRSSSSRPYTKSQWKF Nasonia_vitripennis -----------------------EDGVDVAAKKRKTRRGKPKHRKLKPYSKQSLSYQQRL Nasonia_girault -----------------------EDGVDVAAKKRKTRRGKPKHRKLKPYSKQSLSYQQRL Apis -----------------------EDGIDIAAKKRKTRRGKPKHRKLKPYSKQQLSYQQQL Acyrthosiphon -------------------------------RNRRTRRGKRKSRKQTPYMKDGRLYRD-- Tribolium -----------------------SPECEIPTKKRKTRRGKSKRR--YPYQKNGRKSAK-- Pediculus -----------------------KGKYPYSKTSWQQRRELASSERAQRIRQQMFHHGQ-- Crassostrea --------------------------NQCDSAEKKKRRRRLKGGKHHRKWKPYEKLSWNE Lottia --------------------------DQSGIPRKRKRRRIKGGGRHHKKWKPYDKLTWPE Brugia -----------------------LSASSSHAKTKKSRRRRGGKGRWKPYRTSLKEK---- Ascaris ------------------------------------------------------------ Ancyclostoma ------------------------GDVELEKKRRKTRRR-ANKNRFKPYHSLSPEEKMAL Haemonchus ------------------------GDLETEKKRRKTRRRRANKSRFKPYHSLSPEEKIAL C_elegans ------------------------GES-DGERRLRRSRRKRGGGRFRPYSPDYS------ C_remanei ------------------------GES-DGERRLRRSRRKRGGGRYRPYSPGNS------ C_brenneri ------------------------GES-DSERRLRRSRRKRGAVRARPYSPGNS------ C_briggsae ------------------------GES-DGERRLRRSRRKRGG-RYRPYSP--------- C_japonica ------------------------GESSDAERRLRRSRRKRGGQRVRPYAISPE------ Ixodes ------------------NPDETRARSGSTGKKKKNRRGKSKKRKWKPYYKLSWEERREL Trichinella -----------------------------RRPKRKKRTRRQVRRPWKPYFKLSLEERQRL Capitella -----------------------DKEKGDDSSKWKRNRRKGKGGKHRRGYKPYCKMTWDE Aplysia -------------------------HKKAFQPYPPQDEMKLKRRTLERKEKENAAAVVRR D_sechellia DMTTG--------GGTTLEGNQRQNS--------------------RTKLVRSRSLLVPY D_simulans DMTTG--------AGATLEGNQRQNS--------------------RTKLVRSRSLLVPY D_erecta DMPTN--------AGATLEGNQRQNS--------------------RTKLVRSRSLLVPY D_yakuba DMPTG--------AGATLEGNQRQNS--------------------RTKLVRSRSLLVPY D_melanogaster DMSTG--------AGATLEGNQRQNS--------------------RTKLVRSRSLLVPY D_ananassae DMPAKG------AGGGHVEGNPRQSSS-------------------RTKLVRSRSLLVPY D_persimilis DMASG-------------QGS--TATT-------------------RTKLLRSRSLLVPY D_pseudoobscura DMASG-------------QGS--TATT-------------------RTKLLRSRSLLVPY D_willistoni DMQPGSSAVAGGGAGSGGEASKRHNA--------------------RAKLVRSRSLLVPY D_grimshawi DMLPS-------APGGNGAPSAGSSVS-------------------RSKLVRSRSLLVPY D_virilis DLVTT-------STG-NGATSSGSSSA-------------------RTKLVRSRSLLVPY D_mojavensis DMGAV-------ATM-NSANASCSSGA-------------------RTKLVRSRSLLVPY Bombyx EKP--------------KRNNRFRKI-------------------------VLTKTHAPF Phlebotomus KLP--------------VATRRSAAS-------------------------HIRSSIVPY Anopheles QCPPG------GQPGGGGGGGRPGGGAESNCNKRRHLYSVAASRRITPFLKSDQPPLVPY Aedes HVP---------MLRSTAANKRRVKVSLGGLTTR----SAGIITTKDPFILSDQPPLVPY Culex QNH--------VRIGAAVANKRRAES------------------------LSDHPPLVPY Nasonia_vitripennis RNRAAV-----------------------------------------RPTKTGRQPPAPY Nasonia_girault RNRAAV-----------------------------------------RPTKTGRQPPAPY Apis RYRSRG-----------------------------------------RLAKTGRQPPALY Acyrthosiphon ------------------------------------------------------KAVAPN Tribolium ----------------------------------------------------VIKPEAPY Pediculus -------------------------------------------------------PVAPY Crassostrea RRELEE-----------RETQRATQKR--------------------EEAFAHGHPVAPY Lottia KKALED-----------KETIRATQKR--------------------EEAFASGHPVAPY Brugia IAQEEK------------EERNAVEKR--------------------ERLFSRGKPMAPY Ascaris ------------------------------------------------TLFCRVRLLS-- Ancyclostoma DAAETA------------RSERRTREH-----------------------MAHGKPMAPS Haemonchus DAAETA------------RSERRIRER--------------------XXXMANGKPMAPS C_elegans DDEKTK------------PTKKNQK----------------------RPDKQDRFGMAPP C_remanei DEETAK------------DFDKKQKNK--------------------RAEKPDRFGMAPP C_brenneri NSDDDE------------QQLKQKK----------------------NAYRSDRYGMAPP C_briggsae -DAEQK------------VDKKNRK-----------------------ADKQDRYGMAPP C_japonica NFAVEK------------KPVNKRK-------------------------LRDRRGMAPP Ixodes EERESR------------RANRLR-----------------------QQMFAHGQPVAPY Trichinella ELREER------------RAERIRAQR-----------------------FAHGLPVAPY Capitella KKTQEE-----------RETKRAFKKR--------------------EKRFASGQPMAPY Aplysia EEGGQE---------------------------------------------FIRFPVAPF D_sechellia NTNRFLMEEHMSELH--------------------------------------------- D_simulans NTNRFLMEEHMSELH--------------------------------------------- D_erecta NTNRFLMEEHMSELH--------------------------------------------- D_yakuba NTNRFLMEEHMSELH--------------------------------------------- D_melanogaster NTNRFLMEEHMSELH--------------------------------------------- D_ananassae NTNRFLMEEHMSELP--------------------------------------------- D_persimilis NTNRFLMEEHMSEVP--------------------------------------------- D_pseudoobscura NTNRFLMEEHMSEVP--------------------------------------------- D_willistoni NTNRFLMEEHMSELR--------------------------------------------- D_grimshawi NTNRFLMEEHMSELP--------------------------------------------- D_virilis NTNRFLMEEHMSELP--------------------------------------------- D_mojavensis NTNRFLMEEHMSELP--------------------------------------------- Bombyx NNNQFLMEIHKPEPENAFNILQTPSA---------------------------------- Phlebotomus NTNKFLMEDHMQE-------MQTPKG---------------------------------- Anopheles NTNRFLMEDHMPQ-------VLTPSG---------------------------------- Aedes NTNRFLMEDHMPH-------VLTPSG---------------------------------- Culex NTNRFLMEDHMPQ-------VLTPS----------------------------------- Nasonia_vitripennis NTTQFLMEDHNDLPDLDEKIAGAATGTAGAAAAVAAMAAEVHNHFSKP------------ Nasonia_girault NTTQFLMEDHNDLPDLDEKIAGAATGTAGAAAAVAAMAAEVHNHFSKP------------ Apis NTTQFLMDDHSDLPDLDQKLSEAAS-------------SELPATFQKP------------ Acyrthosiphon NTNQFLMDDHNDGPDIDKKLLARYS----------------------------------- Tribolium NSNQFLLEDHGNIEELDENLKNADQ----------------------H------------ Pediculus NTTQFLIEDHGDLQKIDAQLQVVQE--------------QNPGSSVVN------------ Crassostrea NTTQFLMDDHGK--ADPNIGDGLLNR---------------------------------- Lottia NTTQFLMEDHIQSEASPDLLDVENGE---------------------------------- Brugia NTTQFLVEDHEKRTMPPDVSD-SLPAMVAHQRQSTGVFSPARERCGTI------------ Ascaris ------------------------------------------------------------ Ancyclostoma NTTQFLLEDREARAEQGLE---VELAHEESERRRVRSISVSSEFMAAS------------ Haemonchus NTTQFLLEDREARAEKGLEXXXVELAYEASERKRVRSISVSSEFMAAS------------ C_elegans NSTQFLLEDREARADAEFE---NEQKFEAAERRRVRTMSGSYEHMRP--AYWCTIEPATT C_remanei NSTQFLLDDREARADAEFE---NEQRFEAAERRRVRTMSGSYDHMRP--AYWCTIEPATT C_brenneri NSTQFLLDDREARADAELE---AEQKFEAAERRRVRTMSGSYEHMRPS-AYWCTIEPAHT C_briggsae NSTQFLLDDREARADAEYE---IEQKFEASERRRVRTMSGSYDHMRP--AYWCTVEPATT C_japonica NSTQFLLDDREERANAEYE---NEQKFEAAERRRIRSLSGSFEQMRHAFSGATTIEPATT Ixodes NTTQFLMEDHCVQEPDFESRNGHHRHR--------------------------------- Trichinella NTTQFLLDDREARESEPICVDEIVDTIRHEGAVNDHHGHTKHVPN--------------- Capitella NTTQFLMDQHDSMDSTHLE----------------------------------------- Aplysia NSTQYLMDEHNVNSPVGLHKTPSSSK---------------------------------- D_sechellia ---------------------KDDSDDNCFGSQTEDQVLFLSKEFSDVYERARLERLETM D_simulans ---------------------KDDSDDNCFGSQTEDQVLFLSKEFSDVYERARLERLETM D_erecta ---------------------KDDSDDNCFGSQTEDQVLFLSKEFSDVYERARLERLETM D_yakuba ---------------------KDDSDDNCFGSQTEDQVLFLSKEFSDVYERARLERLETM D_melanogaster ---------------------KDDSDDNCFGSQTEDQVLFLSKEFSDVYERARLERLETM D_ananassae ---------------------KDDSDDNCFSSQTEDQVLFLSKEFSNVYERARLERLETM D_persimilis ---------------------KDDSDDNCFGSQTE--VLFLSKEFSNVYERVRIERLETM D_pseudoobscura ---------------------KDDSDDNCFGSQTE--VLFLSKEFSNVYERVRIERLETM D_willistoni ---------------------KDDSDDNCFGSQTE--VLFLSKEFSNVYERARLERLDTM D_grimshawi ---------------------KDDFDDNCFGNQTEDQELFLSKEFSNVYERARVERLETM D_virilis ---------------------KDDFDDNCFGSQTEDQELFLSKEFSNVYERARVERLETM D_mojavensis ---------------------RDDFEDNCFGSQTEDQELFLSKEFSNVYERARVERLETM Bombyx --------------RTRDSSFSVDSDDNYFYALPEDEEEYLTKEFSSVYEDAQCERLSNM Phlebotomus --------------RQRDSSFSVDSDENYFCSLPEDEEEFLTKEFSSVYENAKCERLDGL Anopheles --------------RTRDSSFSIDSEENYFYSLPEDEEDFLTKEFSSVYERERFERLESL Aedes --------------RTRDSSFSIDSEENYFYSLPEDEEEFLTKEFSSVYEDARSERLEGL Culex ----------------------------------EDEEEFLTKEFSSVYEDARSERLEGL Nasonia_vitripennis ----------IAPSRTRDSSFSVDSDEDYFYSSPEDEEEFLTKEFSSAYEDLHAERLGAL Nasonia_girault ----------IAPSRTRDSSFSVDSDEDYFYSSPEDEEEFLTKEFSSAYEDLHAERLGAL Apis ----------SAPSRTRDSSFSVDSDEDYFYSSPEDEEEFLTKEFSTAYEDLHAERLSTL Acyrthosiphon ----------NENGRTRNSSYTSVESEGDQYSSSSDDGTSIQKEFIDTYRLVQEEELAVL Tribolium ----------STTSRTRDSSFSVDS-EGEFYSSPDDEEQFLIKDFVDQYESVQAERLQSM Pediculus ----------NKPSRARDSSFSIDSDIDYFYSSPEDEEEFLTKEFSNAYEDLHVERLSSM Crassostrea ----------NNSRESTDGSGSTSDSSEEMNS---EEEEFLEKEFAETYDNMHAERLQKM Lottia ----------NINSSLRDSFHSDADGSSDLEYGADEDETFLAKEFSEAYDNIHAERLQTM Brugia ----------------GQSGSEMGGNTTDSASYSGAEDDEMERQFDADYDYVNMERISNM Ascaris -------------------GSDPGGNTSESGSVSGEEGERLEREFDAEYDSVNLMRISGM Ancyclostoma ------------------------EGASSSGDS--ETDKEMDREFEAEFEEYTMDRLSRL Haemonchus ------------------------EGASSSGDS--ETDKEMVREFEADFEEYTMDRISKL C_elegans TADFGSDDN-----------NDLDS---TSGES--EADREMEREFETDYLEVKRERIQSM C_remanei TTYHDDDDR-----------HDVDSGSSSSGES--EADREMEREFETDYLEVKRERIQSM C_brenneri TTASTPSTTNEAAPGYVVEPEDVADNSSCSGSS--CSDREMEREFENEYLEVKRERIQSM C_briggsae TTVALEDHED----------VESVSTSCCSDESEAAADREMEREFESDYQASKRERIQSM C_japonica TTTIASTACGSGSG------CGTDAEESVSGES--EADREMEREFETDYLEVKRERIQSM Ixodes -----------------EDSVNSVDSSDEFYSSPEDEDDFLQKQFSEAYDDVHAERLSSM Trichinella -----------HHHHHHSDHMVGDEYSSDSVTTSEGDLCMLEREFDYEYETAHAERLEEM Capitella ------------------DPKEASFDSSDDFHDSNEDDTFLHKDFDEAYDNYHAERLHAM Aplysia ----------LELCSNSSPAPASVHSTPMHYSQGIMNLEKKDKEFVDIYTSVHAESLQSL ::* : : : D_sechellia SKQELIQECMQIEDRYSK-----------AQNISKEFGAKLRAQDDKIRQLTRENQXXXL D_simulans SKQELIQECLQIEDRYSK-----------AQNISKEFGAKIRAQDDKIRQLTRENQXXXL D_erecta SKQELIQECMQIEDRYSK-----------AQNISKEFGAKIRAQDDKIRQLTRENQXXXL D_yakuba SKQELIQECLQIEDRYSK-----------AQNMSKEFGAKLRAQDDKLRQLTRENQ--FL D_melanogaster SKQELIQECMQIEDRYSK-----------AQNISKEFGAKLRAQDDKIRQLSRENQ--FL D_ananassae SKQDLIQECLAIEDRYSK-----------AQNVSKEFGAKIRALEDKIRQLSRENQXXXI D_persimilis SKAELIQECLQIEDRYSK-----------AQNISKEFGAKIRALDEKMRQLTRENQXXXL D_pseudoobscura SKAELIQECLQIEDRYSK-----------AQNISKEFGAKIRALDEKMRQLTRENQ--FL D_willistoni SKQELIQECLQIEDRYSK-----------AQNVSKECGAKVRSLEDKLRQLTRENQXXXL D_grimshawi SKQELIQECLQVEDRYSKDQGRQRQQSLNAQNISKEYGVKIRALEEKIRELTRENHXXXL D_virilis NKQELIQECLQIEDRYSKDQGRQRQQSLNAQNISKEFGAKIRALEEKIRELTRENQXXXL D_mojavensis SKQELIQECLQIEDRYAKDQGRQRQLSLNAQNISKEFGAKIRALEEKIRDLTRENQXXXL Bombyx TKNELIQEYLLLEAKFENLVKR-----TERSKMKRMEEDKDNSTDRDASIADK------- Phlebotomus TKPQLIQEYLQLEANFEMVSKR-----LTRETNQRHADAKEQMLQRNNYEFQNRIRSLEE Anopheles SHPDLVQEYIKLAIEY-------------------------------------------- Aedes SKSQLIQEYLQLEANYEQVMRR-----YNAVKSLS-----IREENESAVNNATMTTKDAI Culex SKTQLIQEYLQLEANFEQVTRR-----FAAKPAAGGGAASAREENESSVN--AIEVGGGG Nasonia_vitripennis TKTELIQEYIQLEAKVDLL----------TKRLRSKSGQQQQQQQESAEASEPSRDSETA Nasonia_girault TKTELIQEYIQLEAKVDLL----------TKRLRSKSSQQQQQQQESAEASEPSR----- Apis SKSELIQEYLQLEAKVDLL----------TKRLRGKNFHQTEQRD--LESNSSSTDSESA Acyrthosiphon TKNELVQRVIELEEKIQMQ----------ESNKR-------------------------- Tribolium SKDELIQEYLMLESKLELL----------TKRQRKREVTSTSSSVELQSEVERLT----- Pediculus SKSEIIHDYLQLESKYEKT----------LIELKRLKKVGNDEVEGSVQDNDTNE----- Crassostrea SKQELIKDYIEMETKLDR------------LQKRLE--RRNRRIN--------------- Lottia SKEQLVKDYVELERKVET------------LEKKLKDSNQNKRLR--------------- Brugia TKDDVAREYMHLEKINGKL-----------ADRVSFLQLENDKLKQXLKD---------- Ascaris SREEVSSIHQCLHFILFMC-----------AHRST------------------------- Ancyclostoma TKDEMTREILDKEKNAELY-----------QENMSRMMKENQRLRKMLQD---------- Haemonchus HKDGVXXXILDKEKNAELY-----------QENMSKMMKENQRLRKMLID---------- C_elegans TRSQLAAELLERDQDTQVL-----------TRELGSKETENRHLRSLLSA---------- C_remanei TKSQLAAELLERDQDTQQL-----------ARELGSKESENQHLRKLLYA---------- C_brenneri TRSQLAAELLERDQDTQLL-----------ARELGSKESENRHLRNLLSA---------- C_briggsae TKSQLAAELLERDQDTQEL-----------TRELGTKESENRHLRKLLTA---------- C_japonica TRSQLAQELLERDQDTQLL-----------TQELDTMDAENRHLRRLLTA---------- Ixodes SKAELVQEYLLLEDRVEDL----------EQKLRAARAARVDAHTQTAPD---------- Trichinella SKEQLVQEYIHLEKELERY-----------QSESAQLRSAVSELAKRCST---------- Capitella SKGELIAEHLALESKIEDA-----------EKDLKSLKSGNNNSDSELQA---------- Aplysia PKEELVKHYMSLEEKVESL-------------QKEMAVVKQRKLDRAS------------ : : D_sechellia HSHFLRSCPATAG---PAAAAAAAASPPSAVAPTPSSACELQARQQPPQQPQ----PTPM D_simulans HSHFLRSCSATAG---PAAAAAAAASPPSAVAPTPSSACELQARQQPPQQPQ----PTPM D_erecta RSHFLRSCSATAG---PAAAAAAAASPPSAVAPTPSSACELQARQQPPQQPQ----PTPM D_yakuba RSHFLRSCSATAG---PAAAAAAAASPPSAVAPTPSSACELQARQQPPQQPQ----PTPM D_melanogaster RTHLLRTCSATAG---PAAAAAAAASPPSAVAPTPSSACELQARQQPPQQPQ----PTPM D_ananassae RSHYLRSCPTSAG---PAAAAAAAASPPSAVAPTPSSARELQARQQPPQQPQELLQPTPM D_persimilis RSHFLRSCSAAAG---PAAAAAAAASPPSAVAPTASSACELQARQQPAQQQP-----TPM D_pseudoobscura RSHFLRSCSAAAG---PAAAAAAAASPPSAVAPTASSACELQARQQPAQQQP-----TPM D_willistoni RSHFLRSCSTPPGGPAVAAAAAAAASPPSAAAPTPSSASELQARQQPPNQQQ----PTPM D_grimshawi RSHIIRSRSPTTT-----AAAAAAASPPSAAAPTASAVCELQARQQP-QQPP-----TPM D_virilis RLNIIRSCSPTIT-----AAAAAAASPPSAAAPTASAVCELQARQHP-LQP------TPM D_mojavensis RSHMIRPRSPTLL-----VGIAAAASPPSASAPTASAVCELEARQQP-QEP------TPM Bombyx --DSMVTDRDTSE---TSVETFTAEDPPSNEIWQRLKDQEDQIRELQISNEKLLLENEHL Phlebotomus QIDRLTEDNIDLS---RQLEFYRSNAPPPASAGMICSSSEDSESDSSSSSSSSSSSSSDD Anopheles ------------------------------------------------------------ Aedes EGGVALAAAAAAP---VAAATDRRRLEDRIRELTAENLGKCERYGRTL------------ Culex GGGRRLEDRIREL---TAENLELRRQLEHASRIGMVLSAKSSPRPHAAGGAGVERMDSSS Nasonia_vitripennis KKLKVCQQRVDEL-------------------LQQNEQLRRENELLRKQRHGSPMSSVDS Nasonia_girault -----------------------------------TARLPR------------------- Apis KKLKICQQRIDDL-------------------MQQNEQLKRENELLRAKRDGSPVSSVDS Acyrthosiphon ------------------------------------------------------------ Tribolium ---------------------------------IENEALKRENAALR---------SKTC Pediculus ----------------------------------------------------------NG Crassostrea ------------------------------------------------------------ Lottia ------------------------------------------------------------ Brugia ------------------------------------------------------------ Ascaris ------------------------------------------------------------ Ancyclostoma ------------------------------------------------------------ Haemonchus ------------------------------------------------------------ C_elegans ------------------------------------------------------------ C_remanei ------------------------------------------------------------ C_brenneri ------------------------------------------------------------ C_briggsae ------------------------------------------------------------ C_japonica ------------------------------------------------------------ Ixodes ------------------------------------------------------------ Trichinella ------------------------------------------------------------ Capitella ------------------------------------------------------------ Aplysia ------------------------------------------------------------ D_sechellia DSTSEDSESDSSSTTSSTTSSTSSS-SSDGHEMGVAGLNIANGHAER--HERSRTRSRS- D_simulans DSTSEDSESDSSSTTSSTTSSTSSS-SSDGHEMGVAGLNIANGHAER--HERSRTRSRS- D_erecta DSSSEDSESDSSSTTSSTTSSTSSS-SSDGHEMGVAGLNIANGHAER--HERSRTRSRS- D_yakuba DSSSEDSESDSSSTTSSTTSSTSSS-SSDGHEMGVAGLNIANGHAER--HERSRTRSRS- D_melanogaster DSTSEDSESDSSSTTSSTTSTTSST-SSDGHEMGVAGLNIANGHAER--HERSRTRSRS- D_ananassae DSSSEDSESDSSSSTSSTSSNSSSS-SSDGHEMGVAGLNIANGHAER--HDKSRSRSRS- D_persimilis DSSSEDSESDSSSTTSSTTSSTTSN-SSDAHEMGVAGLNIANGHVERSIHEGRGSRSRS- D_pseudoobscura DSSSEDSESDSSSTTSSTTSSTTSN-SSDAHEMGVAGLNIANGHAERSIHEGRGSRSRS- D_willistoni DSSSEDSESDSSSTTSSTTSSTTSSGSSDDHAMGVAGLNIANGHVERSAHSCSRSRSRS- D_grimshawi DSSSEDSESDSSSTTSSTTSSSSSS--SEGHEMGVAGLNIANGHAE-SHRHKSRSHSRSP D_virilis DSSSEDSESDSSSSTSTTTSSSSSS--SEGHEMGVAGLNIANGHAERSVQRHSRSRSGSP D_mojavensis DSSSEDSESDSSSSTSSTTSSSSST--SDGHEMGVAGLNIANGHAESRAHRHSRSHSRSP Bombyx RQRQHNSSEDSESDSSSTSDSNSSSGSEKVVDEPVVQNEPVNDIAQPNGCQEFE------ Phlebotomus QILCTVMRMMSHSSTQGPLCMATHIPVTATVHESITQWGLFAQFPQLH------------ Anopheles ------------------------------------------------------------ Aedes ------------------------------------------------------------ Culex CSSSEDSESDSSSSSSSSSGGSSSSSMSEDEDDGDQDGRRRGELVEDRQPLVAMMDGGEG Nasonia_vitripennis ESDSDSSSNASGCSCNHKTSPGSSPVPASYHARREKTNSRRKNSSVSSVDSESDSTTGDS Nasonia_girault --SSRSVSNAS----------------TSCFSRR---TAQRENECCASRA---------- Apis ESDSDSTSNENRSRCSCLLPNSSSSSELMGYVSRSK-NSQRKDSSVSSTDSKSDTCDSSS Acyrthosiphon ------------------------------------------------------------ Tribolium SSDSEDSETDSNDSCSSTSSSSSSCCSAEAPPSPVLDYSQTNGHSASVETV--------- Pediculus EKEEQDRDTDTSSKSENEVAEQLRITQIENKSLKVELEELRKENKTSSAY---------- Crassostrea DTADDSSASLSTGGKEFVDMDVVR--------------KLEAEHED-------------- Lottia ADENSDGTSLSSSGEELQDLAALKNVGEEMKRLREDNIKMKEQIEELKKKNGGF------ Brugia XNISYEDVLPKIRRHSGTSVSEAGDVVRKSVDEAMGNGRQ-------------------- Ascaris ------------------------------------------------------------ Ancyclostoma NGIPVDHNH------TSQPVV--------------------------------------- Haemonchus NGIVLGENH------TSQSVV--------------------------------------- C_elegans HGISPDEPV------TSTTAI----VVGQSKSPVVAN----------------------- C_remanei HGISPDEPV------TSTTTID---VVVGSKSPVIAN----------------------- C_brenneri HGISPDEPV------SSTTSS----IGNVSKSPVIAN----------------------- C_briggsae HGISPDEPV------TSSTTALQLNAVSASKSPVIAN----------------------- C_japonica HGIHLESPP------DDVTSSG---APCVDKSPVIA------------------------ Ixodes PEQAQKLAVFRDEIRKLADENALVRAQNRALREALDPGPS-------------------- Trichinella --CGHNDVTPPPPPPQLVGLADGEEHQQNGHST--------------------------- Capitella -EIQRLTEENSWLRRENGILKGIKTGEATEC----------------------------- Aplysia ------------------------------------------------------------ D_sechellia --RSPI-LNGHANEEERQRLLDGNQMDEDDNSSDVPRPGDAVVK---- D_simulans --RSPI-LNGHANEEERQRLLDGNQMDEDDNSSDVPRPGDAVVK---- D_erecta --RSPIHLNGHANEEERQRLLDGNQMDEDDNSSDIPRPGDAVVK---- D_yakuba --RSPIHLNGHANEEERQRLLDGNQMDEDDNSSDVPRPGDAVVK---- D_melanogaster --RSPIHLNGHANEEERQRLLDGNQMEEDDNSSDVSRPADAVVK---- D_ananassae --RSPIHLNGHANEEERQALLDSNQMDEDDNSSDGIKQADADVK---- D_persimilis --RSPIHLNGHANEEERLRLLDPNPMDEDGNSSDEPKNGDATDK---- D_pseudoobscura --RSPIHLNGHATEEERLRLLDPNPMDEDGNSSDEPKNGDATDK---- D_willistoni --RSPIQLNGHANDEERSRLLDSNQMDDDENSNDGATNGNPATK---- D_grimshawi ILVIN----GHANEEERLLLLDASRMEEDDNSSEDAKNNDAIDGAPK- D_virilis ALQIDAQLNGHANEEERLLLLDASRMEEDDNSSEDAKNNDAVAGEPE- D_mojavensis QLLIEAHQNGHANEEEQLLLLDASHMEEDDNSSEDAKNNDAVNGEPN- Bombyx ------------------------------------------------ Phlebotomus ------------------------------------------------ Anopheles ------------------------------------------------ Aedes ------------------------------------------------ Culex EPNGYHQLNGVLEEDVIPLENGNGGDFNGAVSPLSAHSINSPPPLVMN Nasonia_vitripennis SCPDGSPKTSTGTTNTDVANGHATSHELDGLPI--------------- Nasonia_girault ------------------------------------------------ Apis S-----ENSKASMTPVNLSNGHVTIQKIDGLPT--------------- Acyrthosiphon ------------------------------------------------ Tribolium ------------------------------------------------ Pediculus ------------------------------------------------ Crassostrea ------------------------------------------------ Lottia ------------------------------------------------ Brugia ------------------------------------------------ Ascaris ------------------------------------------------ Ancyclostoma ------------------------------------------------ Haemonchus ------------------------------------------------ C_elegans ------------------------------------------------ C_remanei ------------------------------------------------ C_brenneri ------------------------------------------------ C_briggsae ------------------------------------------------ C_japonica ------------------------------------------------ Ixodes ------------------------------------------------ Trichinella ------------------------------------------------ Capitella ------------------------------------------------ Aplysia ------------------------------------------------