>Ciona_intestinalis ------------------------------------------------------------ -------------------------------------------------MATDVMRMDPA ATDADCETSGTETHFAGNHRPVSSDPATDI------------------------------ ---------------------ADVGNAKKHHHRR------KPSKKR-RK-WKPYSKMTWE EKREAEEREQVRADRMRGEMIKRGRPVAPYNTTQFIMAEHDNY----EADDDHYDNYN-- -------------NKNQN----VDSSENADGG----VSSTSGAHSMVNHVGSPAVE--TD ---------------------------------------YT----DSPHMAPEFISQDFS ETYERVQEENLSIMSRNDLVQEHINLERNLSYLQDRLAEEKTITNSYSIKMQTVQEQLEA LQQENERLVKENVRLRFGDEGVDTLRTSDYEYEAPNSDQSDDESKISMSVNGGIQPPNGA IELFSLPLKEAAQSSVESMVVSSQSQLSHGAR-------------------------NED YEADVASSEEKEVRERRKRSRNQREKDRVSK-----------ERRISKDGTSDEEEKMNQ KMLRSSNDVEGHSPNGEENNDKTDERSQRSENNGVNFKAKKLRKSDSCFMEVEQWEEKRP STASMESLTSCSNTTN >Ciona_savignyi ----------------------------------------------------------MA ADVMRMDPTAID------------------------------------ADGETSGTETHF AGKRGSGSSETMSESVDVVSAKK------------------------------------- ---------------------------NHHHRRK-------PSKKK-RK-WKPYSKMTWE EKREAEEREQLRADRIRCEMIKRGRPVAPYNTTQFIMAEHDTY----EGDSLDQK----- -------------DQGGSVFSTSGGHSVVNQTESPANTDDFLETDYT--------D--SP ---------------------------------------H---------MAPEFISQDFS EAYERVQEENLSIMSRNDLVQEHISLERNLS----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------YLQVHSPYTVCRT------------------------------------ ------------------------------------------------------------ ---------------- >Strongylocentrotus ------------------------------------------------------------ --------------------------------------------MAVESVQHIPQSRTHH GQQVLRNMQDANDQDGNGND---------------------------------------- ---------------------------KSRKRRR-------PRRKN-RK-WKPYTQLSWE ERQQRDEEESRRAS------LKRANRPTPYNTTQFLMEDHKVV----TPDL--------- -------------SNMGA------------------FDENHDVNLS---------S--SD ---------------------------------------EV-----LENENEEYLVRNFT AVYDEVQSERLQQMSKEQLVNEVLELSKKVS----------------------------- --ELEQILRPGSGGGG-------------------------------------------- --------------EGKLSSEESEGHLDDATR--------------------SRLQSVNE LEEKVEKLKEENKRLRTASYTDKE------------------------------------ ------------------------------------------------------------ ---------------- >Saccoglossus --------------------------------------------------------VHSV LSPTNSPTVDFV---------KFSLRLRSTHRGMPSLE-----RRISGEFSKMEADDQRI ESSECSPDETERSRTRRGGATNNNNHRTET------------------------------ ------------------NGNFVPG--KKKHRRG-------KNKTK-RR-WKPYTEMTWK EKKNLEDREAKRAEEKRK------HRLTPYNTTQFLMEDHKVN----TPDFNMDGTYS-- -------------RQTSM---------------------DSSDELC---------T--SD ---------------------------------------G----------EVQFFEKDFS ETYERLHEEALHSMIKTDLVKEFIRVENYVT----------------------------- --ELEESLKLEKQ----------------------------------------------- ------------------------------KR-------------------------QRD KESRLTEKRSSDDELLAVN----------------------------------------- ------------------------------------------------------------ ---------------- >Branchiostoma -------------------------------------------------NSADFHGSGRF LLA-FMLPREQL--ATMAD-------------------------LEHSVSPEAEGMDGDD ERTETELAEHDSPDSKRECHRNDGGDHPLE------------------------------ ---------------------EHLNDRRRKHHRRGHRGSGAEGRRRFRRKWKPFVKLSWE ERKDLEERERKRAMRVREMMFAEGRTVAPYNTTQFLMEDHETQSXFHSPNL-EVLQRQ-- -----------------------QSNDTSNSD----DMPDSPEDDF---------G--ME ---------------------------------------A------G------FFEKDFS ETYEQFHAESLNNMSKTDLIREYLEMEKCVE-------------------------RLEA KLETASKEDNSSEDKT-------------------------------------------- -----------------------TSPVGN-GR-------------------------ESE LRREVERLRQENAKLQAENTLLKQ------------------GRQNSAPEA--------- ------------------------------------------------------------ ---------------- >H2_Tupaia ------------------------------------------------------------ ------------------------------------------------------------ --------------------------XXXX------------------------------ ---------------------XXXX--XXXXXXX-------XXXXX-XX-XXXXXXXXXX XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXFLMNDRDPE----EPNL-YVPPGV-- -------------SHPGS----------------------SGDSEA---------GD-SD ---------------------------------------GQ-----DR-VHGEFQQRDFS EAYERYHTESLQDRSKQELVRDYLDLEKRLL-------------------------QAE- --EETRRLQQLQACTG-------------------------------------------- -------------------------QQSC-RQ-------------------------VEE LAAEVERLRTENQRLRQENEMWNREG----------------NRRGEEPGT--------- ------------------------------------------------------------ ---------------- >H2_Monodelphis ------------------------------------------------------NSGIS- SSL-GVPSEPSD---------------------------------PGSCQPLTPGMDSPL EWKEPASNNNDSSGQNGTSQFESPGSGPTE------------------------------ ---------------------A-LG--RRKHRRR-------SSKRK-RHGWRPYLELSWA EKQQRDEQQSQRASRVREEMFAKGQAVAPYNTTQFLMEDHDLE----EPDL-ENHQGV-- -------------PHQGS------------------GWEEEDEEEGGGT------GD-LD ---------------------------------------GR-----GK-AQGEFLQRDFS ETYEHYQVESLQGRSKQELVRDYLELEKRLS-------------------------RAE- --EETRRLQQQRDPLG-------------------------------------------- -------------------------PHPC-HR-------------------------AQE LAAEVERLKMENQRLRRENEMWGQGG----------------NSPNGDVGT--------- ------------------------------------------------------------ ---------------- >H2_Spermophilus -------------------------------------------------------SSKCL KRP-SSIPGVSS---SPSSFRQYLWXXXXXXXXXXXXX-----XXXXXXXXXXXXXXXXX XXXXLAQAAGGLSWNCGGPQTQSPGGCSVE------------------------------ ---------------------AVLG--RKKHRRR-------PSKRK-RH-WRPYLELSWA EKQQRDERQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPE----EPNLEVPPYGA-- -------------SHPGS----------------------SGDSEA---------GD-SD ---------------------------------------GQ-----GQ-DHGEFQQRDFS EAYERYHTESLQGRSKQELVRDYLDLERRLT-------------------------QAE- --EETRRLQQLQGRMG-------------------------------------------- -------------------------QQPC-RQ-------------------------VEE LAAEVERLRTENQRLRQEKEMWNQGG----------------SRRHEEPGT--------- ------------------------------------------------------------ ---------------- >H2_Felis ------------------------------------------------------TPGAP- GSP-QTPPEPHD---------------------------------PGSSLPLTPRIESHS EEEDPTGAGSGLGWNNRASRTQSPGGSSVE------------------------------ ---------------------AVLG--RKKHRRR-------PSKRK-RH-WRPYLELSWA EKQQRDERQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPE----EPNLGSAPWGL-- ------------PARLQR-------------------------------------G--ER ---------------------------------------GR-----GK-ATGE-ARLTVS XXXXXXXXXXXXXXXXXXXXXXXXXLERRLS-------------------------QAE- --EETRRLQQLRGCTG-------------------------------------------- -------------------------PQPC-RQ-------------------------VEE LAAEVERLRTENQRLRQENEMWNRKG----------------SCPGGESGT--------- ------------------------------------------------------------ ---------------- >H2_Sorex AECAIVAGCATLGVCHACGVAGHAERSASGWQPAKDSPPGEVLCEPPSLILSLQISGAP- GSP-QTPPESCD---------------------------------PGDSLPQTPQLDSHS EEDDGTGAGGAPGRDCRPSRTQSPEGSSVE------------------------------ ---------------------AVLG--RKKHRRR-------PTKRK-RH-WRPYLELSWA EKQQRDEWQGQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPE----EPNL-DVPHGA-- -------------SHPGS----------------------SGDSEA---------GD-SD ---------------------------------------GH-----GT-AHGEFQQRDSR RXXXXXXXXXXX------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------- >H2_Rattus ------------------------------------------------------TSGGL- RSP-QIAHEPHD---------------------------------FGGSLLLQPGREIQS EDEGTAPAGDGSSCNIRGSRTQSPGGCSVE------------------------------ ---------------------AVLA--RKKHRRR-------PSKRK-RH-WRPYLELSWA EKQQRDERQSQRASRVRQEMFAKGQPLAPYNTTQFLMNDRDLE----EPNL-DVLHGP-- -------------SHADS----------------------GGENEA---------GD-SD ---------------------------------------GL-----GR-AHGEFQQRDFS EAYERYHTESLQGRSKQELVRDYLDLERRLS-------------------------QAE- --QETRRLQQLQGRPS-------------------------------------------- -------------------------RQPC-QQ-------------------------VEE LAAEVERLRTENQRLRQENEMWNREGSYCD------------REKTAAEGTPRPKDEAPL QTRSGQLGHREAGDR--------------------------------------------- ---------------- >H2_Mus ----------------------------------MATVNHTNCNTASPAALEEAKTSGGL RSP-QIAHEPHD---------------------------------FGGSQLLPSGQEIQS EDEGTVPAGDGSSCNIRGSRTQSPGGCSVE------------------------------ ---------------------AVLA--RKKHRRR-------PSKRK-RH-WRPYLELSWA EKQQRDERQSQRASRVREEMFAKGQPLAPYNTTQFLMNDRDLE----EPNL-DVLHGP-- -------------SHSGS----------------------GGENEA----------GDSD ---------------------------------------GQ-----GR-AHGEFQQRDFS EAYERYHTESLQGRSKQELVRDYLDLERRLS-------------------------QAE- --QETRRLRQLQGCSS-------------------------------------------- -------------------------RQPC-QQ-------------------------VEE LAAEVERLRTENQRLRQENEMWNREGGYCD------------QEKPASEGTPWPKVEAPF QTHTGQLGHREAGDR--------------------------------------------- ---------------- >H2_Ochotona ------------------------------------------------------SSGTPL GSP-KMSPETCD---------------------------------PGGSLPLTPQMESQL E-EGLGGAHNGLGWKSRDPQDQGAEGYSVE------------------------------ ---------------------PVLI--RKKHRRR-------PSKRK-RH-WRPYLELSWD EKQQRDEKQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRAPE----EPDL-HVPASI-- -------------SHPDS----------------------SGESEA---------GD-SD ---------------------------------------GR-----DQ-ACGEFQQRDFS EAYERYHAESLQGRSKQELVRDYLDLERRLS-------------------------QAE- --EETRRLQRLQGRSG-------------------------------------------- -------------------------QWHC-RH-------------------------VEE LAAEVERLRTENQRLRQENQMWHPGEGPGTEECPPRQMD---PRPAGSQGGW-------- ------------------------------------------------------------ ---------------- >H2_Myotis -------------------------------------------------------ASDSS RSP-ETPPEPHD---------------------------------PAGSLPLTPRMESHS EEEDPSGAGGGLGCNSRGARTQNPRGCSVE------------------------------ ---------------------AVLG--RKKHRRR-------PSKRK-RH-WRPYLELSWD EKQQRDEKQGQRASRLREEMFAKGQAVAPYNTTQFLMNDRNPE----EPDL-DVPQGA-- -------------SHPGS----------------------SEESEA---------E--DS ---------------------------------------GR-----PVRAPGEFQQRDFS ETYERFHTESLQGRSKQELVQDYLDLERRLS-------------------------LAE- --EETRKLQQLQGRTS-------------------------------------------- -------------------------RQSC-RQ-------------------------VEE LAAEVERLRTENQRLRQENEMWNQEGG---------------QAPRGAPSPV-------- ------------------------------------------------------------ ---------------- >H2_Otolemur ------------------------------------------------------TFSAP- GSP-RTSPQPHD---------------------------------SGDSLPLPPQMESHS EDEDLAGAEGGLGWNGRGPQTQSPGACSAE------------------------------ ---------------------AVLG--RKKHRRR-------PSKRK-RH-WRPYLELSWA EKQQRDERQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPE----EPNL-DVPHSI-- -------------SHPGS---------SGESE--------AGDSDG---------G--AE LKVSSSSGSSLRLMNAITQRACRAAASRSWXXXXXXXXXGRGQRRRGR-AQGEFQQREFS EAYERYHTESLQGRSKQELVTRLPGAGESAR-------------------------VAGX XXXXXXXXXXXXXXXX-------------------------------------------- -------------------------XXXXXXX-------------------------XXX XXXXXXXXXXXXXXXXXXXRDYLELE----------------KARVSQAEE--------- ------------------------------------------------------------ ---------------- >H2_Loxodonta ---------------------------------------------SFAFVLSLQSFRAP- GSP-ETPPVSHD---------------------------------PDRSLPLIPRMDSRP EDEDPAGAAG--GWNNRSPQTQSPAGCSAE------------------------------ ---------------------AVFA--RKKHRRL-------PSKHK-RH-WRPYLELSWA EKQRRDERQSQRAFQVREEMFAKGQPVAPYNTTQFLMNDRDPE----EPDL-DVPHRV-- -------------SHPGS----------------------SGESEA---------GD-SD ---------------------------------------GP-----GQ-AHGEFLQRDFS EAYERY------------------------------------------------------ ------------------------------------------------------------ ------------------------------RH---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------- >H2_Erinaceus ------------------------------------------------------SPGVP- ESP-GTPPEPHD---------------------------------PGDSLPLTPSMKNRS EEED--PAGGAPGWDSKDPRPQNLESCSVE------------------------------ ---------------------AVLG--RKKHRRR-------PSKRK-RH-WRPYLELSWA EKQERDERQSQRASRVREEMFAKGQPVAPYNTTQFLMDDRNPE----EPNL-DVPHGA-- -------------SHPGS----------------------SGESEA---------ED-SD ---------------------------------------GQ-----GQ-ALGEFQQRDFS ETYERYYTESLQDRSKPELVQRYLDLERRLS-------------------------KAE- --EETRRLQQLQGNTC-------------------------------------------- -------------------------QQPC-RQ-------------------------VEE LAAEVERLRTENQRLRQENEMWNREG----------------SRQGGELGT--------- ------------------------------------------------------------ ---------------- >H2_Microcebus ------------------------------------------------------TFSAP- GSP-KTLLEPLD---------------------------------SGGSLPLTPRMESHS EDEDLAGAGSGLGWNSRGPQTQSPGACSAE------------------------------ ---------------------AVLG--RKKHRRR-------PSKRK-RH-WRPYLELSWA EKQQRDERQSQRASRFREKMFAK-----PXXXXXXXXXXXXXX---------XXXXXI-- -------------SHPGS----------------------SGESEAXXXXXX---GRDSD ---------------------------------------GR-----GR-AQGEFQQRDFS ETYERYHTESLQGRSKQELVRDYLELEKRLS-------------------------QAE- --DETRRLQRLQVCTG-------------------------------------------- -------------------------QQPC-RQ-------------------------VEE LAAEVERLRTENQRLRQENEMWNRE----------------------------------- ------------------------------------------------------------ ---------------- >H2_Echinops ------------------LAMGTVASGSEERASFCPKARAAVIPPPCPNPCLSLQSSGAP GSP-ETPSEPQD---------------------------------PGSSLPPTPRMESYS EDEDLTAAGGGLGWPSRSPRAQSPGACSAE------------------------------ ---------------------AVLG--RKKHRRR-------PSKRR-RH-WRPYLELSWA EKQQRDERQSQRASQVREEMFAKGQPVAPYNTTQFLMNDRDPE----EPDL-DVPYGV-- -------------SHPGS----------------------SGESEA---------GD-SD ---------------------------------------GR-----DQ-AHGEFLQRDFS AAYEGYHTESLQGRSKQELVRDYQELERRLS-------------------------QAE- --EEMRRLQQLQRAAS-------------------------------------------- -------------------------QQPS-RQ---------------------------- ---------------------WRS------------------------------------ ------------------------------------------------------------ ---------------- >H2_Oryctolagus -------------------LENDHVSWVGEGGPQAGWAEKGFGPRPSVTPAPSSLLSRPL ALQ-RAPQMPED---------------------------------SGSCLPMTPRMESHL -DEDLAGAGSDLGWKSRGPQTQSSEGCSVE------------------------------ ---------------------AVLG--RKKHRRR-------PSKRK-RH-WRPYLELSWA EKQQRDEKQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPE----EPNL-DVPHGV-- -------------SHPGS----------------------GGESEG---------GD-SD ---------------------------------------GR-----GR-AHGEFQQRDFS EAYERYHTESLQGRSKQELVRDYLDLERRLS-------------------------QAE- --EETRRLQQLQGSTG-------------------------------------------- -------------------------QWRC-RH-------------------------VEE LAAEVERLRTENQRLRQENQMWIRRG----------------SPRDDELGTEECLPRQMD PRPAGSHGGR-------------------------------------------------- ---------------- >H2_Equus ------------------------------------------------------TSGTP- GSP-TTRPEPHD---------------------------------PGGSLPLTPQMESRL EEEDPPGTGGGLGWKTRGPWTRSPGSCSGE------------------------------ ---------------------AVLG--RKRHRRR-------PSKRR-RH-WRPYLELSWA EKRQQDERQGQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPV----EPNL-DVPHGA-- -------------SHPGS----------------------SGDSEA---------GD-SD ---------------------------------------G------GQ-VHGEFQQRDFS EAYERYHTERLQGLSKQELVQDYLDLERRLS-------------------------QAE- --EETRRLQQLQGCIS-------------------------------------------- -------------------------RQPC-RQ-------------------------VEE LAAEVERLRTENQRLRQENEMWNREG----------------SRHNGEPGT--------- ------------------------------------------------------------ ---------------- >H2_Bos ------------------------------VNREGFHHWGEAVCDPSSFVLSLQISGTC- GSP-RTSPEPHD---------------------------------PGGSQPLTPRMESHS EEEDRPGAGGGLGWNGRSPRTQSLGACSAE------------------------------ ---------------------AMLA--RKKHRRR-------PSKRK-RH-WRPYLELSWA EKQQRDERQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPE----EPNL-DVPQGA-- -------------SHPGS----------------------SGESEA---------GD-SD ---------------------------------------GQ-----GR-ARGEFQQKDFS EAYERYHTESLQGRSKEELVRDYLDLERRLS-------------------------QAE- --EEMRRLRQLRGCTN-------------------------------------------- -------------------------WRPC-YQ-------------------------VEE LAAEVERLRTENQRLRQENEMWNREG----------------GRRGGQPGS--------- ------------------------------------------------------------ ---------------- >H2_Canis ------------------------------------------------------TPGAP- GSP-QTPPEPHD---------------------------------PGSSLPLTPRIESHS EEEDSPGAGRGLGWNSRGSRTQSPGGSSVE------------------------------ ---------------------AVLG--RKKHRRR-------PSKRK-RH-WRPYLELSWA EKQQRDERQSQRASRIREEMFAKGQPVAPYNTTQFLMNDRDPE----EPNL-EVPHGA-- -------------SHPGS----------------------SGESEA---------GE-GD ---------------------------------------GQ-----GR-AHGEFQQRDFS EAYERYHTESLQGRSKQELVRDYLDLERRLS-------------------------QAE- --EETRRLKQLRGYTS-------------------------------------------- -------------------------QQPC-CQ-------------------------VEE LAAEVERLRTENLRLRQENAMWNREG----------------SRGKGEPDT--------- ------------------------------------------------------------ ---------------- >H2_Dasypus ----------------------------------------------SLLSCPFQGSGAP- GSP-ATPPEPHD---------------------------------PGISLPLTPRMENHS EDEDPARAGGGLGWNGRRSRPQSPGGCSTK------------------------------ ---------------------AVLG--RKKHRRL-------PSKRK-RH-WRPYLELSWA EKQQRDERQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPE----EPDL-DVPHGV-- -------------SHPGS----------------------SGESEA---------GD-ND ---------------------------------------GP-----GR-AHGEFLQRDFF EAYERYHTESLQGRSKQELVQDYLDLEKRLS-------------------------QAE- --EETRRLQQLQGGTR-------------------------------------------- -------------------------QQSC-RQ-------------------------VEE LAAEIERLRTENQRLRQENEMWIREG----------------GSRSMDPGT--------- ------------------------------------------------------------ ---------------- >H2_Macaca ------------------------------------------------------TSGAP- GSP-QTPPGPHD---------------------------------SGGSLPLTPRMESHS EDEDLAGAVGGLGWYSRSPRTQNPGGCSAE------------------------------ ---------------------AVLA--RKKHRRR-------PSKRK-RH-WRPYLELSWA EKQQRDERQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPE----EPNL-DVPHGI-- -------------SHPGS----------------------SGESEA---------GD-SD ---------------------------------------GR-----GR-AHGEFQRKDFS ETYERFHTESLQGRSKQELVRDYLELEKRLS-------------------------QAE- --EETRRLQQLQACTG-------------------------------------------- -------------------------QQSC-RQ-------------------------VEE LAAEVERLRTENQRLRQENQMWNREG----------------CCCDEEPGT--------- ------------------------------------------------------------ ---------------- >H2_Pongo ------------------------------------------------------TSDAP- GSP-QTPPEPHD---------------------------------SGGSLPLTPRMESHS EDEDLAGAVGGLGWNSRSPRTQSPGGCSAE------------------------------ ---------------------AVLA--RKKHRRR-------PSKRK-RH-WRPYLELSWA EKQQRDERQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPE----EPNL-DVPHGI-- -------------SHPGS----------------------SGESEA---------GD-SD ---------------------------------------GR-----GR-AHGEFQRKDFS ETYERFHTESLQGRSKQELVRDYLELEKRLS-------------------------QAE- --EETRRLQQLQACTG-------------------------------------------- -------------------------QQSC-RQ-------------------------VEE LAAEVERLRTENQRLRQENQMWNREG----------------CRCDEEPGT--------- ------------------------------------------------------------ ---------------- >H2_Homo --------------------------------MMATPNQTACNAESPVALEEAKTSGAP- GSP-QTPPERHD---------------------------------SGGSLPLTPRMESHS EDEDLAGAVGGLGWNSRSPRTQSPGGCSAE------------------------------ ---------------------AVLA--RKKHRRR-------PSKRK-RH-WRPYLELSWA EKQQRDERQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPE----EPNL-DVPHGI-- -------------SHPGS----------------------SGESEA---------GD-SD ---------------------------------------GR-----GR-AHGEFQRKDFS ETYERFHTESLQGRSKQELVRDYLELEKRLS-------------------------QAE- --EETRRLQQLQACTG-------------------------------------------- -------------------------QQSC-RQ-------------------------VEE LAAEVQRLRTENQRLRQENQMWNREG----------------CRCDEEPGT--------- ------------------------------------------------------------ ---------------- >H2_Pan ----------MALWCKRGVTSSRRLLKDLERKMMATPNQTACNAESPVALEEAKTSGAP- GSP-QTPPERHD---------------------------------SGGSLPLTPRMESHS EDEDLAGAVGGLGWNSRSPRTQSPGGCSAE------------------------------ ---------------------AVLA--RKKHRRR-------PSKRK-RH-WRPYLELSWA EKQQRDERQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPE----EPNL-DVPHGI-- -------------SHPGS----------------------SGESEA---------GD-SD ---------------------------------------GR-----GR-AHGEFQRKDFS ETYERFHTESLQGRSKQELVRDYLELEKRLS-------------------------QAE- --EETRRLQQLQACTG-------------------------------------------- -------------------------QQSC-RQ-------------------------VEE LAAEVQRLRTENQRLRQENQMWNREG----------------CRCDEEPGT--------- ------------------------------------------------------------ ---------------- >Petromyzon -----------------------QKLSSPRAIVFIYSKVAAHQHEFYTAHDEQMAAVVSG AVP-GTTDGPEE---------------------GSARR-----CGSGRAGAASPVGAAAR DERGVGDVAAPTPRSHVQTQQQQQQQQPQQ------------------------------ -------------------QPPTAS--RRRHRRR-------PSKKKQRR-WRPYLTLSWE EKKAMEERESERAARMRAEMAAKGLAVAPYNTTQFLMDEHDRE----EPDL--EPAGS-- -------------DGGGG-----DNDGDEDSD--------EGDDGGE--------G--DD ---------------------------------------ELPSRLQGGRDG--FLQRDFS ETYERYHVESLSAMSKGELVREYLELEKCLS-------------------------RLE- --EENLRLR---ECLGERGCWRGPAVALEAKPASRHQAPLAAAAAPSSLRSPPAAEIAPV AVTQQQQQRDEQSTEGPPCAASSGGGVEDPSRGEGGSLAKSHHTHAGGAGDALGKQLVVD LQAEVERLQRENGRLAHQNELLQQQQ----------------PPPEANVME--------- ------------------------------------------------------------ ---------------- >Oryzias --------------------------DVLKRSFRKITIMTEPMEESHQLESLGCPSGESR RDALEHLPVSYH--DGPQSADRGRQREQKQR------------AENHGNINTGNLWQVKG GQREVCPASADGSELSKYPNATPFQRAPDGLPISANSHNPLRKNGQDRALQETLNQVQVA ----------SLLIDSDAGFDARLG--KKRHRRR-------TSKKK-RN-WKPYNKLSWE EKKALEERETLRASRMREEMFAKGLPVAPYNTTQFLMDEHDRE----EPDLNTEARRS-- -------------LGVGG-----RPEETGSEE----EVLDNEQEDDDDDGSGG--G--SD ---------------------------------------GI--GRPGN-AGGEFLQRDFS ETYEMYHVETLQNMSKQELVQEYLELEKCMS-------------------------RLE- --EENNRLRRAVEPGA-------------------------------------------- ------------------------ATESVQVR-------------------------LQE LEVELERLRAENSELHLQSKLSRDQD----------------QGAAQ------------- ------------------------------------------------------------ ---------------- >Gasterostreus ---------------------------------MTEPVQQTHHPKTPGSPSGGSAVDALE HLPARNPARPENGNRGRQRDPKRQQQ-----------------QQHSGDVNTDKLWQKKG GQRGVCASFAAGNVLPKCPNAAQPLQKPDG----LAAIHDPREKNGEDGPPEGTLNPAPE ----------DGHVDSDTGFDARLG--KKRHRRR-------ASKKK-RN-WKPYYKLNWD ERKALEEKETARASRLREEMFAKGLPVAPYNTTQFLMDEHDRV----EPDL-NTESGV-- -------------RRPSGVGGRAEDTGSEEDL----FDNTNEEEEEDDGSGGGG-G--SD ---------------------------------------GI--GRPGN-AGGEFLQRDFS ETYEMYHVESLQNMTKQELVQEYLELEKCMS-------------------------RME- --EENNRLRRAAEPGG-------------------------------------------- ----------------------VTAEGSL-VR-------------------------LRE LERELERLRAQNTQLLLQSQPSEDRG---------------------QVGSN-------- ------------------------------------------------------------ ---------------- >Tetraodon ---------------------------------MTEPAEETHHRETSGSPSGGIGGDAME HLPASNSGGPEEGGRGRQRAQKKPRRAENCEQIGADKLWQPKGGQRGVCPALAGGKELLK CPVAARPHAKAEADGSHESNGKNGGERPLDGTLTRVREE--------------------- ----------GALVDSDTGLDARLG--RRKHRRR-------PSKKK-RN-WKPYFKLSWE ERRALEEKETARASRLREQMFAKGLPVAPYNTTQFLMDEHDRE----EPDL-NTETGA-- -------------RRPCG-----VEDTVSEED----LFEPNPNEDEDDDDGSGGGG--SD ---------------------------------------GI--GRPGN-AGGEFLQRDFS ETYEMYHVESLQNMTKQELVQEYLELEKCMS-------------------------RLE- --EENNRLRRAAEPGA-------------------------------------------- -----------------------LTPESCLLR-------------------------LGE LEKELERLRAQNSELLLQKQP--------------------------------------- ------------------------------------------------------------ ---------------- >Takifugu ---------------------------------MTEPTEQTHHLKTSDSPSGGIGGDAME HLPASNSGAPENGDRGRQREQKKHRRAENCEDISTDKLWQMKGGQRGVCPALAAGNELLK CPIAARPHANADAEGSHESNGKNGGDGQLD---------------------GTLNQVREE ----------SALIDSDTGLDARLG--RRKHRRR-------PSKKK-RN-WKPYFKLSWE ERRALEEKETARASRLREQMFAKGLPVAPYNTTQFLMDEHDRE----EPDL-NTETGI-- -------------RRPCGIGVRIEDTVSEEDL----FDPNPNEDED-DDDGSGG-G--SD ---------------------------------------GI--GRPGN-AGGEFLQRDFS ETYEMYHVESLQNMTKQELVQEYLELEKCMS-------------------------RLE- --EENNRLRRAVEHGG-------------------------------------------- ----------------------LTPESSL-VR-------------------------LGE LERELETLRAQNSELLLLNQPNKDRE----------------QVASN------------- ------------------------------------------------------------ ---------------- >Danio ----------------------------MELIKEETAPEDDSRGRQRDCRTSVVSSKQVQ RNQLEICPGLVS----------------------------------GDVHPM--CRDRSD PEPRTGDAASDDGFPADKTSSKRDSECAAV------------------------------ --------------NTDGVSDGRQG--KKKHRRR-------PSKKK-RR-WKPYFKLTWE EKKELDERETARASRVRAEMFAKGLPVAPYNTTQFLMEEHDRE----EPDL-NTELGG-- -------------RKSGA----IRSEDTASEDENFEAEEDDEEEGGG--------G--SD ---------------------------------------GM--GRPGQ-AGGEFLQKDFS ETYEKYHVEALQNMSKQELVREYLELEKCMS-------------------------RLE- --EENNWLRHVRRNPE-------------------------------------------- ----------------------SPADGTGSQR-------------------------VRE LEVEVEKLRAENNELLLKTPASNEPG-----------------LNQSQPS---------- ------------------------------------------------------------ ---------------- >Xenopus_laevis --------------------------------------------MSEVGICKSLAGGGSL LAP----------------------------------------KEGGGWHHPVEREEHPV GDANTVSEGHDKESAYQNPGQLVKAEAQED------------------------------ -------------------DWKELG--KKRHRRL-------RSKNK-RR-WKPYDKLTWE EKKELEERQSQRASRIRAEMIAKGQPVAPYNTTQFLMEDHDQE----EPDLCPPPRKS-- -----------SAALPLALNNSSYKGDSTDDD------LEEEEDEA---------G--SD ---------------------------------------GM-----GGYDGEDFLQKDFS ETYERYHAESLQDMSKQDLIKEYLELEKCLS-------------------------RME- --EENNHLRVQSLASA-------------------------------------------- ----------------------PAADHRD-TR-------------------------IQE LQVELEKLKEENQRLLQE------------------------GKQVAADSP--------- ------------------------------------------------------------ ---------------- >Xenopus_tropicalis --------------------------------------------MSELGICKSLAGGGSL LAS-KEGSGWQPVEEVEREEH-----------------------PVRDPNPVSCREQKDP DKEGGCQKPGQLAKA--KPQQEGDW----------------------------------- ---------------------KELG--KKRHRRL-------PSKNK-RK-WKPYCKLTWE EKKNLEERASQRASRIRAEMIAKGQPVAPYNTTQFLMEDHDQE----EPDLCPPPRKS-- -------------SAALPLAIINSSYKGSTDD------LEEEEDET---------G--SD ---------------------------------------GM-----GVYDGEDFLQKDFS ETYERYHAESLQDMSKQELIREYMELEKCLS-------------------------RME- --DENNRLRLQSLTST-------------------------------------------- -------------------------PVAD--H---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------- >Callorhinchus ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------LVG----------------------VS-LEPYFKLTWE EKKELDERESVRAAKTRAEMFAKGFTVAPYNTTQFLMDEHDRE----EPDL-NPGFCPHA VAAAAAAAAAHHHKRGAG-----KADDSSGEDDELLLLEEAEEEES---------G--SD ---------------------------------------GM-----GG-SGSEFLQRDFC ETYERYHAETLQNMSKQELIREYLELEKCLS-------------------------RLE- --DEKNRLRRRLEATD-------------------------------------------- ----PRPGLGSGLALGLEPELQEEEEEEEKER-------------------------ERE VQREVERLRAENRRLEEENELSHRGRGGEGECGLGSPNPASCRSASSNLQD--------- ------------------------------------------------------------ ---------------- >Ornithorhynchus -----------------------MRSGRLTALSAKRQAGGPLGAAGAAGSCSSRDVAVDR KRSRAFLTLPLQGISDVRDNQRSRVGHSETVQGQNGA------CWSPGLTYGKPHGDSGG TSSPRTLLDPNDPWDVPPPTPGMGASPEAP----------------------------AS ----------PLEGETPAPRPKAPG--RRKHRRR-------PSKQK-RP-RRPYLQLSWA EKQQRDERQSQRASRLRAQMFAKGQPAAPYNTTQFLMDDHDQE----EPDL-KTGLYP-- -------------KRAAA-----KSDDTSDED----FVEEAGEEDG---------G--SD ---------------------------------------GM-----GG-DGGEFLQRDFS ETYQRFYFESLRSWGKEALIREGL---------------------------------LE- --DEP------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------- >Taeniopygia ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------KLALWWI-------PKKKR-R--WKPYSKLSWE EKQQFDERQSLRASRLRAEMFAKGQPVAPYNTTQFLMEDHDQE----EPDL-KTGLYP-- -------------RRAAA-----KSDDTSEED----FLDDAADEDG---------G--SD ---------------------------------------GM-----GG-DGSEFLQRDFS ETYERYHVESLQNMSKQELVKEYLELEKCLS-------------------------RME- --EENNRLRMESKKAG-------------------------------------------- ------------------------GEAADPAR-------------------------VQA LEREVDRLRAENLRLLREQELPRQEK------------------GPCKPGE--------- ------------------------------------------------------------ ---------------- >Gallus -------------------------------------------------------MADAE RAPEAAPADPEP---------------------ERGEA-----QTDGESGRLPPPEEAAE AATAAEGAGDHEARPSEGGAAQPGLRPRYR------------------------------ --------------AAVGRAQEWPA--KKKHRRR-------PSKNK-RR-WNPYSKLSWE EKQQFDERQSLRASRLRAEMFAKGQPVAPYNTTQFLMEDHDQE----EPDL-KTGLYP-- -------------RRSAA-----KSDDTSEED----FLEEAAEEDG---------G--SD ---------------------------------------GM-----GG-DGSEFLQRDFS ETYERYHVESLQNMSKQELVKEYLELEKCLS-------------------------RME- --DENNRLRMESKK---------------------------------------------- -------------------------HGEAAEA-------------------------ARL LEIEVDRLRAENLQLLRERDV---------------------RAAEAAPE---------- ------------------------------------------------------------ ---------------- >H1_Sorex ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------GQQLRQLG--KKKHRRR-------PSQKK-RH-WKPYYKLTWG GEEKSSTKRQ-----------SPGEPSXXXXXXXXXXXXXXXX----XXXX-XXXXXX-- -------------XXX---------------------------------------G--SD ---------------------------------------GM-----GG-DGSEFLQRDFS ETYERYHAESLQNMSKQELIKEYLELEKCLS-------------------------RME- --DENNRLRLESKR---------------------------------------------- -------------------------PGED-AR-------------------------VRE LELELE------------------------------------------------------ ------------------------------------------------------------ ---------------- >Anolis -------------------------FDNKFEPAMADVAVSSSQQQPNGKSSPVSLCLGAG GGD-----GDGD---------------------------------GGGPFLASPPSNQGT APRRGSGAAGGSRERPHKQQDGREDACLGAEQGSFSRRGRVRWRWLRTVAQLRVDRFIAG FCPCREYFGPRYRPQAAGEEERQLG--KKKHRRR-------PSKKK-RH-WKPYYKLTWE EKKKFDEKQSQRASRLRAEMFAKGQPVAPYNTTQFLMEDHDQE----EPDL-KTGLCP-- -------------KKAAA-----KPEDTSEEE----F---VEEEDG---------G--SD ---------------------------------------GM-----GG-DGSEFLQKDFS ETYERFHVESLQNMSKQELIQEYLELEKCLS-------------------------RME- --EENNRLRMENKKFS-------------------------------------------- -----------------------GDSTED-PR-------------------------VSQ LEQELDRLRAENQKLLKENELGRQQE-----------------KSVSKLGE--------- ------------------------------------------------------------ ---------------- >H1_Cavia ------------------------------------------XXXXXAADAGASEGDGRW RSR-ASPPG-----------------------------------GMGSPAPLQDPGDGDG GGAAGPGGDGEPSPAPPGPDAEAPRTAWGP------------------------------ -------------------QPRQLG--KKKHRRR-------PSKKK-RH-WKPYYKLSWE EKRKFDERQSLRASRVRAEMFAKGQPVAPYNTTQFLMDDHDQE----EPDL-KTGLCP-- -------------RRAAK-------SDSSDED----FLEEAGEEDG---------G--SD ---------------------------------------GM-----GG-DGGEFLQRDFS ETYERYHAESLQNMSKQELIREYLELEKCLS-------------------------RME- --DENNRLRLESRRP--------------------------------------------- -------------------------GGDE-AR-------------------------VRE LELELDRLRAENLRLLRQSERPRAPE-----------------------QD--------- ------------------------------------------------------------ ---------------- >H1_Monodelphis ----------------------------------MAECQQQQQTSQTSSNCTGAMGRAER YTE---PPGEDC---------RWQSRASSELDEILGKE-----EGGGNPAPAPPPRPTLA CLDPGCPEGGEKGQNHDNLTAVGTAAAAAQPLGEGHRPGTQPPQSCQGYGGDKFAVPVGQ ----------EEEAWRQQQQQRQLG--KKKHRRR-------PSKKK-RH-WKPYYKLTWE EKKKFDEKQSQRASRVRAEMFAKGQPVAPYNTTQFLMDDHDQE----EPDL-KTGLYT-- -------------KRAAA-----KSDDTSDED----FLEEAGEEDG---------G--SD ---------------------------------------GM-----GG-DGSEFLQRDFS ETYERYHAESLQNMSKQELIKEYMELEKCLS-------------------------RME- --DENNRLRLESKKF--------------------------------------------- --------------------------GED-SR-------------------------VRE LELELDRLKAENLQLLKENELHRQQE----------------RAPLSKFGD--------- ------------------------------------------------------------ ---------------- >H1_Ochotona ---------------------HLSNLDKRTPLAMAESLLSEYQHQPQTSNCTGAAVVPGE -NA-ECAPGAEE--RVPAEDSRWQSRASPESDGRPGP------AGEGS--PEPPQTQAGA -------DPGDRGRNGAGLATGGAPSPAAG--ADP---------PGQDSEANKLEAPAAG ----------GEAAW--GHQQRHLG--KKKHRRR-------PSKKK-RH-WKPYYKLTWE EK---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------- >H1_Myotis ---------------------------------MAEPLVSEFQHQPQTGNCAGADAVQEE RNP-DRPPGAEE--PVPQDDSRWQARALPQPGGRPGP------EGEGSLDPQPSPLPTQV CPEPRCLEADEKGQNGDDSSAGGPAPPPAG--GEQRPETEPLTQPCHDSEANKLGAPAAG ----------GEESW--KQQQRQLG--KKKHRRR-------PSKKK-RH-WKPYYKLTWE EKRKFDEKQSLRASRVRAEMFAKGQPVAPYNTTQFLMDDHDQE----EPDL-KTGFYP-- -------------KRAAA-----KS-DTSDEE----FMEEAGEEDG---------G--SD ---------------------------------------GM-----GG-DGSEFLQRDFS ETYERFHAESLQNMSKQELIREYLELEKCLS-------------------------RME- --DENNRLRLESKRLG-------------------------------------------- ------------------------GGGDD-AR-------------------------VRE LELELDRLRAENLQLLTENELHRQQE----------------RAPLSKFGD--------- ------------------------------------------------------------ ---------------- >H1_Rattus ---------------------------------MAEPLLSEHQHQPQTSNCTGAAVVHEE QNS-ERPPSAEE--RVPKEDSRWQSRASLQSGSRPGQ------EGDGGLKHQLPPLQTNA CPELSCLEKGEKGQNGEDLSTGGASPSAEG-----EPMSESLVQPGHDSEATKLEAPVAG ----------VEEPW--GQQQRQLG--KKKHRRR-------PSKKK-RH-WKPYYKLTWE EKKKFDEKQSLRASRVRAEMFAKGQPVAPYNTTQFLMDDHDQE----EPDL-KTGLYP-- -------------KRAAA-----KSDDTSDED----FVEEAGEEDG---------G--SD ---------------------------------------GM-----GG-DGSEFLQRDFS ETYERYHAESLQNMSKQELIKEYLELEKCLS-------------------------RKE- --DENNRLRLESKRL--------------------------------------------- -------------------------GGVD-AR-------------------------VRE LELELDRLRAENRQLLTENELHRQQE----------------RAPPSKFGD--------- ------------------------------------------------------------ ---------------- >H1_Mus ---------------------------------MAEPLLTEHQHQPQTSNCTGAAVVHEE HTS-ERPPSAEE--RVPKEDSRWQSRASLQSGSRPGQ------EGEGGLKHQLPPLQTNA CPELSSLEKGEKGQNGEDLSTGGASPSAEG-----EPMSESLVQPGHDSEATKQEAPAAG ----------GEEPW--GQQQRQLG--KKKHRRR-------PSKKK-RH-WKPYYKLTWE EKKKFDEKQSLRASRVRAEMFAKGQPVAPYNTTQFLMDDHDQE----EPDL-KTGLYP-- -------------KRAAA-----KSDDTSDED----FVEEAGEEDG---------G--SD ---------------------------------------GM-----GG-DGSEFLQRDFS ETYERYHAESLQNMSKQELIKEYLELEKCLS-------------------------RKE- --DENNRLRLESKRL--------------------------------------------- -------------------------GGVD-AR-------------------------VRE LELELDRLRAENLQLLTENELHRQQE----------------RAPLSKFGD--------- ------------------------------------------------------------ ---------------- >H1_Macaca ---------------------------------MAEPFLSEYQHQPQTSNCTGAAAVQEE PNP-ERPPGAEE--RVPEEDSRWQSRAFPQLGGRPGP------EGEGSLESQPPPLQPQA CPESSCLIKGEKGQNGDDLSAGGDFPPPAE--GEPKPEAELLAQPCHDSEASKLGAPAAG ----------GEEEW--GQQQRQLG--KKKHRRR-------PSKKK-RH-WKPYYKLTWE EKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQE----EPDL-KTGLYS-- -------------KRAAA-----KSDDTSDDD----FMEEGGEEDG---------G--SD ---------------------------------------GM-----GG-DGSEFLQRDFS ETYERYHTESLQNMSKQELIKEYLELEKCLS-------------------------RME- --DENNRLRLESKRL--------------------------------------------- -------------------------GGDD-AR-------------------------VRE LELELDRLRAENLQLLTENELHRQQE----------------RAPLSKFGD--------- ------------------------------------------------------------ ---------------- >H1_Pan ---------------------------------MAEPFLSEYQHQPQTSNCTGAAAVQEE LNP-ERPPGAEE--RVPEEDSRWQSRAFPQLGGRPGP------EGEGSLESQPPPLQTQA CPESSCLREGEKGQNGDDSSAGGDFPPPAE--VEPTPEAELLAQPCHDSEASKLGAPAAG ----------GEEEW--GQQQRQLG--KKKHRRR-------PSKKK-RH-WKPYYKLTWE EKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQE----EPDL-KTGLYS-- -------------KRAAA-----KSDDTSDDD----FMEEGGEEDG---------G--SD ---------------------------------------GM-----GG-DGSEFLQRDFS ETYERYHTESLQNMSKQELIKEYLELEKCLS-------------------------RME- --DENNRLRLESKRL--------------------------------------------- -------------------------GGDD-AR-------------------------VRE LELELDRLRAENLQLLTENELHRQQE----------------RAPLSKFGD--------- ------------------------------------------------------------ ---------------- >H1_Homo ---------------------------------MAEPFLSEYQHQPQTSNCTGAAAVQEE LNP-ERPPGAEE--RVPEEDSRWQSRAFPQLGGRPGP------EGEGSLESQPPPLQTQA CPESSCLREGEKGQNGDDSSAGGDFPPPAE--VEPTPEAELLAQPCHDSEASKLGAPAAG ----------GEEEW--GQQQRQLG--KKKHRRR-------PSKKK-RH-WKPYYKLTWE EKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQE----EPDL-KTGLYS-- -------------KRAAA-----KSDDTSDDD----FMEEGGEEDG---------G--SD ---------------------------------------GM-----GG-DGSEFLQRDFS ETYERYHTESLQNMSKQELIKEYLELEKCLS-------------------------RME- --DENNRLRLESKRL--------------------------------------------- -------------------------GGDD-AR-------------------------VRE LELELDRLRAENLQLLTENELHRQQE----------------RAPLSKFGD--------- ------------------------------------------------------------ ---------------- >H1_Pongo --------------------------TSRTLLAMAEPFLSEYQHQPQTSNCTGAAAVQEE LNP-ERPPGAEE--RVPEEDSRWQSRAFPQLGGRPGP------EGEGSLESQPPLLQTQA CPESSCLREGEKGQNGDDSSAGGDFPPPAE--MEPTPEAELLAQPCHDSEASKLGAPAAG ----------GEEEW--GQQQRQLG--KKKHRRR-------PSKKK-RH-WKPYYKLTWE EKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQE----EPDL-KTGLYS-- -------------KRAAA-----KSDDTSDDD----FMEEGGEEDG---------G--SD ---------------------------------------GM-----GG-DGSEFLQRDFS ETYERYHTESLQNMSKQELIKEYLELEKCLS-------------------------RME- --DENNRLRLESKRL--------------------------------------------- -------------------------GGDD-AR-------------------------VRE LELELDRLRAENLQLLTENELHRQQE----------------RAPLSKFGD--------- ------------------------------------------------------------ ---------------- >H1_Oryctolagus TLGHLQREKRKSFFPSRIQSQHFANFEKRTPLAMAEPLLSEYQHQPPTSNCTGAAVVREE QKP-ERPPGAEE--RVPEEDSRWQSRAAPQPGGPPGP------EGEGSPQPQA------- -----CLEPGEKSQNGGDLSAAGEPRAEAC----------------QDSEPNKLEAPAAG ----------AKEAW--GQQQRHLG--KKKHRRR-------PSKKK-RH-WKPYYKLTWE EKKKFDEKQSLRASRLRAEMFAKGQPVAPYNTTQFLMDDHDQE----EPDL-KTGLYP-- -------------KRAAA-----KSDDTSDED----FMDEAGEEDG---------G--SD ---------------------------------------GM-----GG-DGSEFLQRDFS ETYERYHAESLQNMSKQELIKEYLELEKCLS-------------------------RME- --DENNRLRLESKR---------------------------------------------- -------------------------PGDD-AR-------------------------VRE LELELDRLRAENLQLLTENELHRQE-----------------RAPLSKFGD--------- ------------------------------------------------------------ ---------------- >H1_Bos ---------------------------------MAEPLLSEFQHQPQTSNCTGAVAVHEE RNP-DRPPGAEE--RVPEEDSRWQSRASPKSGGSPGH------GGEGSLEPQPSPLKTQV CPESSCPEAGEKGQNGDDLSAGGAPPQQ-------------------------------- ---------------------RQVG--KKKHRRR-------PSKKK-RL-WKPYYTLTWE EKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQE----EPDL-KTGLYP-- -------------KRAAA-----KSDDTSDED----FMEEAGEEDG---------G--SD ---------------------------------------GM-----GG-DGSEFLQRDFS ETYERYHAESLQNMSKQELIKEYLELEKCLS-------------------------RME- --DENNRLRLESQRL--------------------------------------------- -------------------------DGDD-AR-------------------------VRE LELELDRLRAENLQLLTENELHRQQE----------------RAPLSNFGD--------- ------------------------------------------------------------ ---------------- >H1_Otolemur ---------------------------------MAEPLLSEYQHQPQTSNYTGAAVVHEE RNP-ERPPGAEE--RVLEEDSRWQSRASPQSGGLPVP------EGEGSLEPQPPPLQTQA YSQPTCLEAGEKGQNGDDLSTGDASPPAAG--GEPRPEAELNAQPCHDSEANKLGAPAAG ----------DEEAW--GQQQRQLG--KKKHRRR-------PSKKK-RH-WKPYIKLTWE EKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMEDHDQE----EPDL-KTGLYS-- -------------KRAAA-----KSDDTSDED----FMEEAGEEDG---------G--SD ---------------------------------------GM-----GG-DGSEFLQRDFS ETYERYHAESLQNMSKQELIKEYLELEKCLS-------------------------RME- --DENNRLRLESKRL--------------------------------------------- -------------------------GSDD-AR-------------------------VRE LELELDRLRAENLQLLTENELHRQQE----------------RAPLSKFGD--------- ------------------------------------------------------------ ---------------- >H1_Microcebus ---------------------------------MAEPLLSEYQHQPQTSNCTGAAVVHED RNP-ERPPGAEE--RVPEEDSRWQSRASPQPGGPPGL------EGEGSLEPHPPPLQTQA RSEPSCLEAGEMGQNGDDLSADGDSPPAAG--GEPRPEAEPIAQPRHDSEANKLGAPAAG ----------GEEAC--GQQQRQLG--KKKHRRR-------PSKKK-RH-WKPYIKLTWE EKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQE----EPDL-KTGLYS-- -------------KRAAA-----KSDDTSDED----FMEEAGEEDG---------G--SD ---------------------------------------GM-----GG-DGSEFLQRDFS ETYERYHAESLQNMSKQELIKEYLELEKCLS-------------------------RME- --DENNRLRLESKRL--------------------------------------------- -------------------------GSDD-AR-------------------------VRE LELELDRLRAENLQLLSENELHRQQE----------------RAPLSKFWRL-------- ------------------------------------------------------------ ---------------- >H1_Sus ----------------GLNSQNSSNFEKRILLAMDEPLLSEYQHQPQTSNCTGAAAVHEE RNP-DRPPGAEE--RVPEEDSRWQSRASPQSGGRPGQ------EGEGSQEPQLPPLQTQV SPESSCPEAGEKGQNGDDLSAGGAPPPAAG--GEQRP------------EANKLGASAAG ----------GEEAW--GQQQRQLG--KKKHRRR-------PSKKK-RL-WKPYYTLTWE EKKKFDEKESLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQE----EPDL-KTGLYP-- -------------KRAAA-----KSDDTSDED----FMEEAGEEDG---------G--SD ---------------------------------------GM-----GG-DGSEFLQRDFS ETYERYHAESLQNMSKQELIREYLELEKCLS-------------------------RME- --DENNRLRLESKRLG-------------------------------------------- -------------------------GGDD-AR-------------------------VRE LELELDRLRAENLQLLTENELHRQQE----------------RAPLSKFGD--------- ------------------------------------------------------------ ---------------- >H1_Erinaceus ------------------------------------------------------------ GQQ--------------------------------------------------------- ------------------------------------------------------------ ---------------------RQLG--KKKHRRR-------PSKKK-RH-WKPYYKLTWE EKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQE----EPDL-KTGLYP-- -------------KRAAT-----KSDDTSDED----FMEEAGEEDG---------G--SD ---------------------------------------GM-----GG-DGSEFLQRDFS ETYERYHAESLQNMSKQELIKEYLELEKCLS-------------------------RME- --DENNRLRLESKRL--------------------------------------------- -------------------------GGDD-AR-------------------------VRE LELELDRLRAENLQLLTENELHRQQE----------------QAPLSKFGD--------- ------------------------------------------------------------ ---------------- >H1_Canis -----------------GLTAKIYKLREEDSISHGRATLIRIQHQPQTSNCTGAVAVHDE RNP-DRPPGAEE--RVPEEDSRWQSRASPQSGGRPGQ------EGEGSLGPQPPPLQTPV RPEPSCPEAGKKGQNGDDLSAGGASPPAAG--GEPKPEAEPLAQPCLDSEANKLGAPAAG ----------GEEAW--GQQQRQLG--KKKHRRR-------PSKKK-RH-WKPYYKLTWE EKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQE----EPDL-KTGLYP-- -------------KRAAA-----KSDDTSDED----FMEEAGEEDG---------G--SD ---------------------------------------GM-----GG-DGSEFLQRDFS ETYERYHAESLQNMSKQELIKEYLELEKCLS-------------------------RME- --DENNRLRLESKRL--------------------------------------------- -------------------------GGDD-AR-------------------------VRE LELELDRLRAENLQLLTENELHRQQE----------------RAPLSKFGD--------- ------------------------------------------------------------ ---------------- >H1_Equus ---------------------------------MAEPLLSEYQHQPQTSNCTGAAAVHEE RNP-DRPPGAEE--RVPKEDSRWQSRASPKSDGRPGL------EGEGSLEPQPPPLQTQM CPESGCLEAGEKSHNGDDLSAGGAPPPVAG--GEPRPGAEPLAQPCPDSEANKLGAPAAG ----------GEEAW--GQQQRQLG--KKKHRRR-------PSKKK-RH-WKPYYKLTWE EKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQE----EPDL-KTGLYP-- -------------KRAAA-----KSDDTSDED----FMEEAGEEDG---------G--SD ---------------------------------------GM-----GG-DGSEFLQRDFS ETYERYHAESLQNMSKQELIKEYLELEKCLS-------------------------RME- --DENNRLRLESKRL--------------------------------------------- -------------------------GGDD-AR-------------------------VRE LELELDRLRAENLQLLTENELHRQQE----------------RAPLSKFGD--------- ------------------------------------------------------------ ---------------- >H1_Felis ------------------------------------------------------------ -------PRPEA------------------------------------EPLAQPCHDSEA NKLGAPAAGGEEAW---------------------------------------------- -----------------GQQQRQLG--KKKHRRR-------PSKKK-RH-WKPYYKLTWE EKKKFDEKQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQE----EPDL-KTGLYP-- -------------KRAAA-----KSDDTSDED----FMEEAGEEDG---------G--SD ---------------------------------------GM-----GG-DGSEFLQRDFS ETYERYHAESLQNMSKQELIKEYLELEKCLS-------------------------RME- --DENNRLRLESKRL--------------------------------------------- -------------------------GGDD-AR-------------------------VRE LELELDRLRAENLQLLSENELHRQQE----------------RAPLSKFGD--------- ------------------------------------------------------------ ----------------