CLUSTAL 2.0.9 multiple sequence alignment Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -------------------------------------------------- Schistosoma_japonicum -------------------------------------------------- Echinococcus_multilocularis -------------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis -------------------------------------------------- Apis_mellifera -------------------------------------------------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum -------------------------------------------------- Lottia_gigantea -------------------------------------------------- Ixodes_scapularis -------------------------------------------------- Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -------------------------------------------------- Ciona_intestinalis -------------------------------------------------- Ciona_savignyi -------------------------------------------------- Trichoplax_adhaerens -------------------------------------------------- Danio_rerio -------------------------------------------------- Tetraodon_nigroviridis -------------------------------------------------- Pan_troglodytes -------------------------------------------------- Homo_sapiens -------------------------------------------------- Macaca_mulatta -------------------------------------------------- Pongo_pygmaeus -------------------------------------------------- Canis_familiaris_t2 -------------------------------------------------- Canis_familiaris_t1 -------------------------------------------------- Equus_caballus -------------------------------------------------- Sus_scrofa -------------------------------------------------- Felis_catus -------------------------------------------------- Loxodonta_africana -------------------------------------------------- Mus_musculus -------------------------------------------------- Rattus_norvegicus -------------------------------------------------- Bos_taurus -------------------------------------------------- Monodelphis_domestica -------------------------------------------------- Microcebus_murinus -------------------------------------------------- Echinops_telfari -------------------------------------------------- Spermophilus_tridecemlineatus -------------------------------------------------- Ochotona_princeps -------------------------------------------------- Oryctolagus_cuniculus -------------------------------------------------- Dasypus_novemcinctus -------------------------------------------------- Sorex_araneus -------------------------------------------------- Anolis_carolinensis -------------------------------------------------- Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes -------------------------------------------------- Takifugu_rubripes -------------------------------------------------- Capitella_capitata -------------------------------------------------- Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae -------------------------------------------------- Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus -------------------------------------------------- Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii -------------------------------------------------- Reniera_sp -------------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans -------------------------------------------------- Drosophila_erecta -------------------------------------------------- Drosophila_melanogaster MEKRLSDSPGDCRVTRSTMTPTLRLDQTSRQEPLPQQPDNGPAAAPGKSK Drosophila_yakuba -------------------------------------------------- Drosophila_sechellia -------------------------------------------------- Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi -------------------------------------------------- Drosophila_ananassae -------------------------------------------------- Drosophila_mojavensis -------------------------------------------------- Drosophila_willistoni -------------------------------------------------- Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis -------------------------------------------------- Anopheles_gambiae -------------------------------------------------- Aedes_aegypti -------------------------------------------------- Bombyx_mori -------------------------------------------------- Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -------------------------------------------------- Schistosoma_japonicum -------------------------------------------------- Echinococcus_multilocularis -------------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis -------------------------------------------------- Apis_mellifera -------------------------------------------------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum -------------------------------------------------- Lottia_gigantea -------------------------------------------------- Ixodes_scapularis -------------------------------------------------- Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -------------------------------------------------- Ciona_intestinalis -------------------------------------------------- Ciona_savignyi -------------------------------------------------- Trichoplax_adhaerens -------------------------------------------------- Danio_rerio -------------------------------------------------- Tetraodon_nigroviridis -------------------------------------------------- Pan_troglodytes -------------------------------------------------- Homo_sapiens -------------------------------------------------- Macaca_mulatta -------------------------------------------------- Pongo_pygmaeus -------------------------------------------------- Canis_familiaris_t2 -------------------------------------------------- Canis_familiaris_t1 -------------------------------------------------- Equus_caballus -------------------------------------------------- Sus_scrofa -------------------------------------------------- Felis_catus -------------------------------------------------- Loxodonta_africana -------------------------------------------------- Mus_musculus -------------------------------------------------- Rattus_norvegicus -------------------------------------------------- Bos_taurus -------------------------------------------------- Monodelphis_domestica -------------------------------------------------- Microcebus_murinus -------------------------------------------------- Echinops_telfari -------------------------------------------------- Spermophilus_tridecemlineatus -------------------------------------------------- Ochotona_princeps -------------------------------------------------- Oryctolagus_cuniculus -------------------------------------------------- Dasypus_novemcinctus -------------------------------------------------- Sorex_araneus -------------------------------------------------- Anolis_carolinensis -------------------------------------------------- Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes -------------------------------------------------- Takifugu_rubripes -------------------------------------------------- Capitella_capitata -------------------------------------------------- Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae -------------------------------------------------- Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus -------------------------------------------------- Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii -------------------------------------------------- Reniera_sp -------------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans -------------------------------------------------- Drosophila_erecta -------------------------------------------------- Drosophila_melanogaster SPTPLPGKSQAAQHHQFRAPQQQQGPKNRNKAWSKRQHKAGGKHNPSACV Drosophila_yakuba -------------------------------------------------- Drosophila_sechellia -------------------------------------------------- Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi -------------------------------------------------- Drosophila_ananassae -------------------------------------------------- Drosophila_mojavensis -------------------------------------------------- Drosophila_willistoni -------------------------------------------------- Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis -------------------------------------------------- Anopheles_gambiae -------------------------------------------------- Aedes_aegypti -------------------------------------------------- Bombyx_mori -------------------------------------------------- Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -------------------------------------------------- Schistosoma_japonicum -------------------------------------------------- Echinococcus_multilocularis -------------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis -------------------------------------------------- Apis_mellifera -------------------------------------------------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum -------------------------------------------------- Lottia_gigantea -------------------------------------------------- Ixodes_scapularis -------------------------------------------------- Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -------------------------------------------------- Ciona_intestinalis -------------------------------------------------- Ciona_savignyi -------------------------------------------------- Trichoplax_adhaerens -------------------------------------------------- Danio_rerio -------------------------------------------------- Tetraodon_nigroviridis -------------------------------------------------- Pan_troglodytes -------------------------------------------------- Homo_sapiens -------------------------------------------------- Macaca_mulatta -------------------------------------------------- Pongo_pygmaeus -------------------------------------------------- Canis_familiaris_t2 -------------------------------------------------- Canis_familiaris_t1 -------------------------------------------------- Equus_caballus -------------------------------------------------- Sus_scrofa -------------------------------------------------- Felis_catus -------------------------------------------------- Loxodonta_africana -------------------------------------------------- Mus_musculus -------------------------------------------------- Rattus_norvegicus -------------------------------------------------- Bos_taurus -------------------------------------------------- Monodelphis_domestica -------------------------------------------------- Microcebus_murinus -------------------------------------------------- Echinops_telfari -------------------------------------------------- Spermophilus_tridecemlineatus -------------------------------------------------- Ochotona_princeps -------------------------------------------------- Oryctolagus_cuniculus -------------------------------------------------- Dasypus_novemcinctus -------------------------------------------------- Sorex_araneus -------------------------------------------------- Anolis_carolinensis -------------------------------------------------- Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes -------------------------------------------------- Takifugu_rubripes -------------------------------------------------- Capitella_capitata -------------------------------------------------- Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae -------------------------------------------------- Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus -------------------------------------------------- Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii -------------------------------------------------- Reniera_sp -------------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans -------------------------------------------------- Drosophila_erecta -------------------------------------------------- Drosophila_melanogaster GASSGQAQSTGSSVIAATLLPTAASAHKADLENIQNIHNKNLTAGGGVNH Drosophila_yakuba -------------------------------------------------- Drosophila_sechellia -------------------------------------------------- Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi -------------------------------------------------- Drosophila_ananassae -------------------------------------------------- Drosophila_mojavensis -------------------------------------------------- Drosophila_willistoni -------------------------------------------------- Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis -------------------------------------------------- Anopheles_gambiae -------------------------------------------------- Aedes_aegypti -------------------------------------------------- Bombyx_mori -------------------------------------------------- Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -------------------------------------------------- Schistosoma_japonicum -------------------------------------------------- Echinococcus_multilocularis -------------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis -------------------------------------------------- Apis_mellifera -------------------------------------------------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum -------------------------------------------------- Lottia_gigantea -------------------------------------------------- Ixodes_scapularis -------------------------------------------------- Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -------------------------------------------------- Ciona_intestinalis -------------------------------------------------- Ciona_savignyi -------------------------------------------------- Trichoplax_adhaerens -------------------------------------------------- Danio_rerio -------------------------------------------------- Tetraodon_nigroviridis -------------------------------------------------- Pan_troglodytes -------------------------------------------------- Homo_sapiens -------------------------------------------------- Macaca_mulatta -------------------------------------------------- Pongo_pygmaeus -------------------------------------------------- Canis_familiaris_t2 -------------------------------------------------- Canis_familiaris_t1 -------------------------------------------------- Equus_caballus -------------------------------------------------- Sus_scrofa -------------------------------------------------- Felis_catus -------------------------------------------------- Loxodonta_africana -------------------------------------------------- Mus_musculus -------------------------------------------------- Rattus_norvegicus -------------------------------------------------- Bos_taurus -------------------------------------------------- Monodelphis_domestica -------------------------------------------------- Microcebus_murinus -------------------------------------------------- Echinops_telfari -------------------------------------------------- Spermophilus_tridecemlineatus -------------------------------------------------- Ochotona_princeps -------------------------------------------------- Oryctolagus_cuniculus -------------------------------------------------- Dasypus_novemcinctus -------------------------------------------------- Sorex_araneus -------------------------------------------------- Anolis_carolinensis -------------------------------------------------- Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes -------------------------------------------------- Takifugu_rubripes -------------------------------------------------- Capitella_capitata -------------------------------------------------- Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae -------------------------------------------------- Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus -------------------------------------------------- Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii -------------------------------------------------- Reniera_sp -------------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans -------------------------------------------------- Drosophila_erecta -------------------------------------------------- Drosophila_melanogaster HGNAGTAHHGGGGGAGAHHAAAGGHHHHHNTRLAQNAAAGGASGGGTIQM Drosophila_yakuba -------------------------------------------------- Drosophila_sechellia -------------------------------------------------- Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi -------------------------------------------------- Drosophila_ananassae -------------------------------------------------- Drosophila_mojavensis -------------------------------------------------- Drosophila_willistoni -------------------------------------------------- Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis -------------------------------------------------- Anopheles_gambiae -------------------------------------------------- Aedes_aegypti -------------------------------------------------- Bombyx_mori -------------------------------------------------- Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -------------------------------------------------- Schistosoma_japonicum -------------------------------------------------- Echinococcus_multilocularis -------------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis -------------------------------------------------- Apis_mellifera -------------------------------------------------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum -------------------------------------------------- Lottia_gigantea -------------------------------------------------- Ixodes_scapularis -------------------------------------------------- Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -------------------------------------------------- Ciona_intestinalis -------------------------------------------------- Ciona_savignyi -------------------------------------------------- Trichoplax_adhaerens -------------------------------------------------- Danio_rerio -------------------------------------------------- Tetraodon_nigroviridis -------------------------------------------------- Pan_troglodytes -------------------------------------------------- Homo_sapiens -------------------------------------------------- Macaca_mulatta -------------------------------------------------- Pongo_pygmaeus -------------------------------------------------- Canis_familiaris_t2 -------------------------------------------------- Canis_familiaris_t1 -------------------------------------------------- Equus_caballus -------------------------------------------------- Sus_scrofa -------------------------------------------------- Felis_catus -------------------------------------------------- Loxodonta_africana -------------------------------------------------- Mus_musculus -------------------------------------------------- Rattus_norvegicus -------------------------------------------------- Bos_taurus -------------------------------------------------- Monodelphis_domestica -------------------------------------------------- Microcebus_murinus -------------------------------------------------- Echinops_telfari -------------------------------------------------- Spermophilus_tridecemlineatus -------------------------------------------------- Ochotona_princeps -------------------------------------------------- Oryctolagus_cuniculus -------------------------------------------------- Dasypus_novemcinctus -------------------------------------------------- Sorex_araneus -------------------------------------------------- Anolis_carolinensis -------------------------------------------------- Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes -------------------------------------------------- Takifugu_rubripes -------------------------------------------------- Capitella_capitata -------------------------------------------------- Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae -------------------------------------------------- Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus -------------------------------------------------- Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii -------------------------------------------------- Reniera_sp -------------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans -------------------------------------------------- Drosophila_erecta -------------------------------------------------- Drosophila_melanogaster HKKMLRGHHHHVLCAGNNANHTCCLVTGCNGSSIGGVGVAGSGGATASAG Drosophila_yakuba -------------------------------------------------- Drosophila_sechellia -------------------------------------------------- Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi -------------------------------------------------- Drosophila_ananassae -------------------------------------------------- Drosophila_mojavensis -------------------------------------------------- Drosophila_willistoni -------------------------------------------------- Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis -------------------------------------------------- Anopheles_gambiae -------------------------------------------------- Aedes_aegypti -------------------------------------------------- Bombyx_mori -------------------------------------------------- Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -------------------------------------------------- Schistosoma_japonicum -------------------------------------------------- Echinococcus_multilocularis -------------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis -------------------------------------------------- Apis_mellifera -------------------------------------------------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum -------------------------------------------------- Lottia_gigantea -------------------------------------------------- Ixodes_scapularis -------------------------------------------------- Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -------------------------------------------------- Ciona_intestinalis -------------------------------------------------- Ciona_savignyi -------------------------------------------------- Trichoplax_adhaerens -------------------------------------------------- Danio_rerio -------------------------------------------------- Tetraodon_nigroviridis -------------------------------------------------- Pan_troglodytes -------------------------------------------------- Homo_sapiens -------------------------------------------------- Macaca_mulatta -------------------------------------------------- Pongo_pygmaeus -------------------------------------------------- Canis_familiaris_t2 -------------------------------------------------- Canis_familiaris_t1 -------------------------------------------------- Equus_caballus -------------------------------------------------- Sus_scrofa -------------------------------------------------- Felis_catus -------------------------------------------------- Loxodonta_africana -------------------------------------------------- Mus_musculus -------------------------------------------------- Rattus_norvegicus -------------------------------------------------- Bos_taurus -------------------------------------------------- Monodelphis_domestica -------------------------------------------------- Microcebus_murinus -------------------------------------------------- Echinops_telfari -------------------------------------------------- Spermophilus_tridecemlineatus -------------------------------------------------- Ochotona_princeps -------------------------------------------------- Oryctolagus_cuniculus -------------------------------------------------- Dasypus_novemcinctus -------------------------------------------------- Sorex_araneus -------------------------------------------------- Anolis_carolinensis -------------------------------------------------- Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes -------------------------------------------------- Takifugu_rubripes -------------------------------------------------- Capitella_capitata -------------------------------------------------- Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae -------------------------------------------------- Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus -------------------------------------------------- Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii -------------------------------------------------- Reniera_sp -------------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans -------------------------------------------------- Drosophila_erecta -------------------------------------------------- Drosophila_melanogaster GGGASCKEAQSCKDTSSLSGNSSIAGSAGAGNAVHYCCGRSKFFLPEKRL Drosophila_yakuba -------------------------------------------------- Drosophila_sechellia -------------------------------------------------- Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi -------------------------------------------------- Drosophila_ananassae -------------------------------------------------- Drosophila_mojavensis -------------------------------------------------- Drosophila_willistoni -------------------------------------------------- Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis -------------------------------------------------- Anopheles_gambiae -------------------------------------------------- Aedes_aegypti -------------------------------------------------- Bombyx_mori -------------------------------------------------- Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -------------------------------------------------- Schistosoma_japonicum -------------------------------------------------- Echinococcus_multilocularis -------------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis -------------------------------------------------- Apis_mellifera -------------------------------------------------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum -------------------------------------------------- Lottia_gigantea -------------------------------------------------- Ixodes_scapularis -------------------------------------------------- Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -------------------------------------------------- Ciona_intestinalis -------------------------------------------------- Ciona_savignyi -------------------------------------------------- Trichoplax_adhaerens -------------------------------------------------- Danio_rerio -------------------------------------------------- Tetraodon_nigroviridis -------------------------------------------------- Pan_troglodytes -------------------------------------------------- Homo_sapiens -------------------------------------------------- Macaca_mulatta -------------------------------------------------- Pongo_pygmaeus -------------------------------------------------- Canis_familiaris_t2 -------------------------------------------------- Canis_familiaris_t1 -------------------------------------------------- Equus_caballus -------------------------------------------------- Sus_scrofa -------------------------------------------------- Felis_catus -------------------------------------------------- Loxodonta_africana -------------------------------------------------- Mus_musculus -------------------------------------------------- Rattus_norvegicus -------------------------------------------------- Bos_taurus -------------------------------------------------- Monodelphis_domestica -------------------------------------------------- Microcebus_murinus -------------------------------------------------- Echinops_telfari -------------------------------------------------- Spermophilus_tridecemlineatus -------------------------------------------------- Ochotona_princeps -------------------------------------------------- Oryctolagus_cuniculus -------------------------------------------------- Dasypus_novemcinctus -------------------------------------------------- Sorex_araneus -------------------------------------------------- Anolis_carolinensis -------------------------------------------------- Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes -------------------------------------------------- Takifugu_rubripes -------------------------------------------------- Capitella_capitata -------------------------------------------------- Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae -------------------------------------------------- Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus -------------------------------------------------- Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii -------------------------------------------------- Reniera_sp -------------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans -------------------------------------------------- Drosophila_erecta -------------------------------------------------- Drosophila_melanogaster RKEVIVPPTKFLLGGNISDPLNLNSLQNENTSNASSTNNTPATTPRQSPI Drosophila_yakuba -------------------------------------------------- Drosophila_sechellia -------------------------------------------------- Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi -------------------------------------------------- Drosophila_ananassae -------------------------------------------------- Drosophila_mojavensis -------------------------------------------------- Drosophila_willistoni -------------------------------------------------- Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis -------------------------------------------------- Anopheles_gambiae -------------------------------------------------- Aedes_aegypti -------------------------------------------------- Bombyx_mori -------------------------------------------------- Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -------------------------------------------------- Schistosoma_japonicum -------------------------------------------------- Echinococcus_multilocularis -------------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis -------------------------------------------------- Apis_mellifera -------------------------------------------------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum -------------------------------------------------- Lottia_gigantea -------------------------------------------------- Ixodes_scapularis -------------------------------------------------- Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -------------------------------------------------- Ciona_intestinalis -------------------------------------------------- Ciona_savignyi -------------------------------------------------- Trichoplax_adhaerens -------------------------------------------------- Danio_rerio -------------------------------------------------- Tetraodon_nigroviridis -------------------------------------------------- Pan_troglodytes -------------------------------------------------- Homo_sapiens -------------------------------------------------- Macaca_mulatta -------------------------------------------------- Pongo_pygmaeus -------------------------------------------------- Canis_familiaris_t2 -------------------------------------------------- Canis_familiaris_t1 -------------------------------------------------- Equus_caballus -------------------------------------------------- Sus_scrofa -------------------------------------------------- Felis_catus -------------------------------------------------- Loxodonta_africana -------------------------------------------------- Mus_musculus -------------------------------------------------- Rattus_norvegicus -------------------------------------------------- Bos_taurus -------------------------------------------------- Monodelphis_domestica -------------------------------------------------- Microcebus_murinus -------------------------------------------------- Echinops_telfari -------------------------------------------------- Spermophilus_tridecemlineatus -------------------------------------------------- Ochotona_princeps -------------------------------------------------- Oryctolagus_cuniculus -------------------------------------------------- Dasypus_novemcinctus -------------------------------------------------- Sorex_araneus -------------------------------------------------- Anolis_carolinensis -------------------------------------------------- Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes -------------------------------------------------- Takifugu_rubripes -------------------------------------------------- Capitella_capitata -------------------------------------------------- Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae -------------------------------------------------- Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus -------------------------------------------------- Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii -------------------------------------------------- Reniera_sp -------------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans -------------------------------------------------- Drosophila_erecta -------------------------------------------------- Drosophila_melanogaster TTPPKVEVIIPPNIHDPLHLLDPVDSMEYEKQLTSPMKRAGPGGGMLHHR Drosophila_yakuba -------------------------------------------------- Drosophila_sechellia -------------------------------------------------- Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi -------------------------------------------------- Drosophila_ananassae -------------------------------------------------- Drosophila_mojavensis -------------------------------------------------- Drosophila_willistoni -------------------------------------------------- Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis -------------------------------------------------- Anopheles_gambiae -------------------------------------------------- Aedes_aegypti -------------------------------------------------- Bombyx_mori -------------------------------------------------- Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -------------------------------------------------- Schistosoma_japonicum -------------------------------------------------- Echinococcus_multilocularis -------------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis ----------------------------------------------MYSG Apis_mellifera -------------------------------------------------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum -------------------------------------------------- Lottia_gigantea -------------------------------------------------- Ixodes_scapularis -------------------------------------------------- Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -------------------------------------------------- Ciona_intestinalis -------------------------------------------------- Ciona_savignyi -------------------------------------------------- Trichoplax_adhaerens -------------------------------------------------- Danio_rerio -------------------------------------------------- Tetraodon_nigroviridis -------------------------------------------------- Pan_troglodytes -----------------------------------------------MIE Homo_sapiens -----------------------------------------------MIE Macaca_mulatta -----------------------------------------------MIE Pongo_pygmaeus -----------------------------------------------MIE Canis_familiaris_t2 -----------------------------------------------MIE Canis_familiaris_t1 -----------------------------------------------MIE Equus_caballus -----------------------------------------------MIE Sus_scrofa -----------------------------------------------MIE Felis_catus -----------------------------------------------MIE Loxodonta_africana -----------------------------------------------MIE Mus_musculus -----------------------------------------------MIE Rattus_norvegicus -----------------------------------------------MIE Bos_taurus -------------------------------------------------- Monodelphis_domestica -----------------------------------------------MIE Microcebus_murinus -----------------------------------------------MIE Echinops_telfari -------------------------------------------------- Spermophilus_tridecemlineatus -------------------------------------------------- Ochotona_princeps ------------------------------------------------SR Oryctolagus_cuniculus -----------------------------------------------XXX Dasypus_novemcinctus -------------------------------------------------- Sorex_araneus -------------------------------------------------- Anolis_carolinensis ------------------------------------------------SR Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes -------------------------------------------------- Takifugu_rubripes -------------------------------------------------- Capitella_capitata -------------------------------------------------- Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae -------------------------------------------------- Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus -------------------------------------------------- Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii -------------------------------------------------- Reniera_sp -------------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans -------------------------------------------------- Drosophila_erecta -------------------------------------------------- Drosophila_melanogaster QHHYRTRKNRKRRRFDSNNTSHAGDEGGVGSELTDEPPLPAATSSLAASP Drosophila_yakuba -------------------------------------------------- Drosophila_sechellia -------------------------------------------------- Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi -------------------------------------------------- Drosophila_ananassae -------------------------------------------------- Drosophila_mojavensis -------------------------------------------------- Drosophila_willistoni -------------------------------------------------- Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis -------------------------------------------------- Anopheles_gambiae -------------------------------------------------- Aedes_aegypti -------------------------------------------------- Bombyx_mori -------------------------------------------------- Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -------------------------------------------------- Schistosoma_japonicum -------------------------------------------------- Echinococcus_multilocularis -------------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis DSSVEDASGDIFVEIGEVGRWLGGRGVTGLALTAALKYILKQSMSLAALN Apis_mellifera -------------------------------------------------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum -------------------------------------------------- Lottia_gigantea -------------------------------------------------- Ixodes_scapularis -------------------------------------------------- Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -------------------------------------------------- Ciona_intestinalis -------------------------------------------------- Ciona_savignyi -------------------------------------------------- Trichoplax_adhaerens -------------------------------------------------- Danio_rerio MSVQSELPIAGGAAG--------------LLAHPPSPLQTIKDEVTANIV Tetraodon_nigroviridis MSVDEESVKAGAAQAC---------STSLQLSEGAGSYSTVSVTVEATDA Pan_troglodytes MAAEKEPFLVPAPPPP-LKDESGGGGGPTVPPHQEAASGELRGGTERGPG Homo_sapiens MAAEKEPFLVPAPPPP-LKDESGGGGGPTVPPHQEAASGELRGGTERGPG Macaca_mulatta MAAEKEPFLVPAPPPP-LKDESGGGGGPTVPPHQEAASGELCGGTERGPG Pongo_pygmaeus MAAEKEPFLVPAPPPP-LKDESGGGGGPTVPPHQEAASGELRGGTERGPG Canis_familiaris_t2 MAAEKEPFLVPAPPPP-LKDESGGGGGPTLQPHREAASGELCGGTQRGPG Canis_familiaris_t1 MAAEKEPFLVPAPPPP-LKDESGGGGGPTLQPHREAASGELCGGTQRGPG Equus_caballus MAAEKEPFLVPAPPPP-LKEESGGGGGPTVQPHREAASGELRGGTQRGPG Sus_scrofa MAAEKEPFLVPAPPPP-LKDESGGGGGPTVQPHREVASGELRGGTQRGPG Felis_catus MAAEKEPFLVPAPPPPPLKEESGGGGGPTVQPHREAASGELCGGTQRGPG Loxodonta_africana MAAEKEPFLVPAPPPP-LKDESSGGGGPTVQSHREAASGHLRGRTERGPG Mus_musculus MAAEKEPFLVPAPPPP-LKDESGGGGGPEVQSHQEAASGELRDGTEHGPG Rattus_norvegicus MAAEKEPFLVPAPPPP-LKDESGGGGGPEVRSHQEAASGELLDGTERGPG Bos_taurus -------------------------------------------------- Monodelphis_domestica MAAEKEPFLVPAPPPL--KSDSSGGGGTLVQPHREASSGELCGGTAQGTS Microcebus_murinus MAAEKEPFLVPAPPPP-LKDQSGGGGGPSVPPYQEAASGELRGGTERGPG Echinops_telfari -------------------------------------------------- Spermophilus_tridecemlineatus --------VGRRGRAL------------AVQPHREAASRELRGRTERGPG Ochotona_princeps WRRKRSRFWCRPRRRR------------SKRSRAEEGSAPRCPHTERRPL Oryctolagus_cuniculus XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX Dasypus_novemcinctus -------------------------------------------------- Sorex_araneus -------------------------------------------------- Anolis_carolinensis WRRTRRPSESRPRRRR-----------CQNPRPREPRPVEPGTCLERQPG Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes -------------------------------------------------- Takifugu_rubripes -------------------------------------------------- Capitella_capitata -------------------------------------------------- Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae -------------------------------------------------- Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus -------------------------------------------------- Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii -------------------------------------------------- Reniera_sp -------------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans -------------------------------------------------- Drosophila_erecta -------------------------------------------------- Drosophila_melanogaster VAAPLNVGGSLLLSESAAPAPGETAEMGQQQEQAHVHSPQSASTTTTAAE Drosophila_yakuba -------------------------------------------------- Drosophila_sechellia -------------------------------------------------- Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi -------------------------------------------------- Drosophila_ananassae -------------------------------------------------- Drosophila_mojavensis -------------------------------------------------- Drosophila_willistoni -------------------------------------------------- Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis -------------------------------------------------- Anopheles_gambiae -------------------------------------------------- Aedes_aegypti -ESHSSAANAVVNYRPMEGQTLVLPERGGGGRDEGGGVGTEELRAFASVA Bombyx_mori -----------------------------------MGSPEEKITACEAVN Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -------------------------------------------------- Schistosoma_japonicum -------------------------------------------------- Echinococcus_multilocularis -------------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis YMRICLSNPSTTVPQHTSRRILLIWLIIVAFVVNSYVLSYFTAMESSSNR Apis_mellifera -------------------------------------------------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum -------------------------------------------------- Lottia_gigantea -------------------------------------------------- Ixodes_scapularis -------------------------------------------------- Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -------------------------------------------------- Ciona_intestinalis -------------------------------------------------- Ciona_savignyi -------------------------------------------------- Trichoplax_adhaerens -------------------------------------------------- Danio_rerio LTELAANHVTPQDG------------------------------------ Tetraodon_nigroviridis APAFAASCPVLPTA------------------------------------ Pan_troglodytes RCAPSAGSPASAVGRESPGAAATSPSG-PQAQQHRGGGPQAQSHGEAR-- Homo_sapiens RCAPSAGSPAAAVGRESPGAAATSSSG-PQAQQHRGGGPQAQSHGEAR-- Macaca_mulatta PCAPSAGSPAAGVGRESPGAAATPPGG-PQAQQHRGGGPQAQSHGEAR-- Pongo_pygmaeus PCAPSAGSPAAGVGRESPGAAATSPGG-PQAQQHRGGGPQAQSHGEAR-- Canis_familiaris_t2 PRTHSTGVPASG---------------------QRGGGPQAQSHGEAR-- Canis_familiaris_t1 PRTHSTGVPASGVGKESPGATST--RG-GQSQQQRGGGPQAQSHGEAR-- Equus_caballus PRAHSEGALASGAGKESPRAPSTP-RG-GQAQQQRGGGPQAPPHGEAR-- Sus_scrofa PRAHSAGSPASGAGKESPGATSTP-RG-GQSQQQRGGGPQAQSTGEAC-- Felis_catus PRAHSAGTPASGAGKESPGATST--RG-GQSQQHRGDSPQAQSHGEAR-- Loxodonta_africana PRVQSAGAPALGVGRESPGAASAPRAGQSQQQQQRGGGPQAQSHGEAR-- Mus_musculus PRAHSAGAAASG-----------------------GGGPQAQAHGEP--- Rattus_norvegicus PRAHSAGATASG-----------------------GGGPQAQTHGEP--- Bos_taurus -------------------------------------------------- Monodelphis_domestica PHIPTVSGREGFPAPSPPRAGQNP---------HRGGGSMAQ--GEAR-- Microcebus_murinus PRAHSAGAAASGAGTESPRAASTPRGG--PAQQHRGGGPQTQSHGEAXXX Echinops_telfari -------------------------------------------------- Spermophilus_tridecemlineatus RSAHSAGATA------SPRGGQGQ--------QHRGGGPQAQSHGEAP-- Ochotona_princeps PGSPAAARSANRVSAHTPAGDGES--------PGAPATPQAQSHGEAR-- Oryctolagus_cuniculus XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX-- Dasypus_novemcinctus -------------------------------------------------- Sorex_araneus -------------------------------------------------- Anolis_carolinensis KVAAGRGRAKGPAAAGMEAS-------------QRLLRPRQTPSEGAR-- Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes -------------------------------------------------- Takifugu_rubripes -------------------------------------------------- Capitella_capitata ----------MSVEV---------KTPTREQFEHSEFPCPSSSIGVRPGL Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae --MAATESIVASQEVNVSMDILDGKQTLLEVVEEVEGQSQELANHGRDGL Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus ----------MSTKVLEASPESGNRNDPFSSNNANIYVQGTLKNARIGGT Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii -------------------------------------------------- Reniera_sp -------------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans -------------------------------------------------- Drosophila_erecta -------------------------------------------------- Drosophila_melanogaster MPTPTPTSAAAATATAEHKEQSAPAPTATSSPQRQQQHVAAAAEELPTPE Drosophila_yakuba -------------------------------------------------- Drosophila_sechellia -------------------------------------------------- Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi -------------------------------------------------- Drosophila_ananassae -------------------------------------------------- Drosophila_mojavensis -------------------------------------------------- Drosophila_willistoni -------------------------------------------------- Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis -------------------------------------------------- Anopheles_gambiae -------------------------------------------------- Aedes_aegypti EQGETAAEKTQLCPPRTRSQGGSNKKQQNKHFSRQQCKSKKWKLNKFRRN Bombyx_mori ENEARDTIDKSELNTSDITESAANESNEQILNDANASKDSDTPGAGISKK Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -----------------MRHLRGSASYSREHRVSARSYCFPQPRGVA--- Schistosoma_japonicum --------------------------SRNCVLVSTRSCCFSHPRGVS--- Echinococcus_multilocularis -------------TRWKSLRLHFLFFFSVELLMRSLSSNLYLIRKYLPLD Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis SPVIDTYDDLIKSDLALMGPRSFKELTEQREIQNRFELVTDDRIKDCFDL Apis_mellifera -------------------------------------------------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum -----------------MATKTEVENETIEKPLENQDLNAVCTNLQFCDD Lottia_gigantea -------------------------------------------------- Ixodes_scapularis -------------METAVEVPSLHVDVSSKRAGVFQRSTCRSASTDSQAR Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -------------------------------------------------- Ciona_intestinalis -----------MATAVTMSPSNCDAMKQQKPDIVSSVQVPSGNTGQSSSG Ciona_savignyi -----------MATAVTMSPSSCDAMKPNNE--LNSVPANPPMPRNNIQ- Trichoplax_adhaerens ----------------MLSREDREYDK----------------------- Danio_rerio ----VTAEG--------------PFQIKNGLQTRTEVQTQKLAQ-----K Tetraodon_nigroviridis ----ASPKRRTAALADSDAGQQKPKGNENNLSRRNTLHHSKQQQQTKLAK Pan_troglodytes -LSDPPGRAAPPDVGEERRGGGGTELGPPAPPRPRNGYQPHRPPGGGGGK Homo_sapiens -LSDPPGRAAPPDVGEERRGGGGTELGPPAPPRPRNGYQPHRPPGGGGGK Macaca_mulatta -LSDPPGRAAPPDVGEERRGGGGTELGPPAPPRPRNGYQPHRPPGGGGGK Pongo_pygmaeus -LSDPPGRAAPPDVGEERRGGGGTELGPP-PPRPRNGYQPHRPPGGGGGK Canis_familiaris_t2 -LSDPHGRAAPPDVGEERRGGGGTELGPPAPPRPRNGYQPHRPPGGGGGK Canis_familiaris_t1 -LSDPHGRAAPPDVGEERRGGGGTELGPPAPPRPRNGYQPHRPPGGGGGK Equus_caballus -LSDPHGRAAPPDVGEERRGGGGTELGPPAPPRPRNGYQPHRPPGGGGGK Sus_scrofa -LSDPQGLAAPPDVGEERRGGGGTELGPLAPPRPRNGYQPHRPPGGGGGK Felis_catus -LSXX--------XGEERRGGGGTELGPPAPPRPRNGFQPHRPPGGGGGK Loxodonta_africana -LSDPHGRTAHLDVGEERRGGGGPELCPPAPPRPRNGYQPHRPPGGGGGK Mus_musculus ----HGRAAAPADVGEERRGGGGTDLGPPAPPRPRNGYQPHRPPGGGGGK Rattus_norvegicus ----HGRAAAPADVGEERRGGGGTDLGPPAPPRPRNGYQPHRPPVGGGGK Bos_taurus -------------------------------------------------- Monodelphis_domestica -QPEAHGEAPPPDMEEERRGWGGAELGPPAPPRQRNGFQPHRPPGGGGSK Microcebus_murinus RLSDPHGRAAPLDLGEERRGGGGTELGPPAPPRPRNGYQPHRPPGGGGGK Echinops_telfari ------------------------------------------APAGGGGS Spermophilus_tridecemlineatus -LSDPPGRAAPPDVGEERRGGGGTELGPPAPPRPRNGYQPHRAPGGGGGK Ochotona_princeps -VSDPHGRAAPPDVGEERRGGGGTELGPPAPPRPRNGYQPHRPPGGGGGK Oryctolagus_cuniculus XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX Dasypus_novemcinctus -------------------------------------------------- Sorex_araneus -------------------------------------------------- Anolis_carolinensis ----PLGRRATAWTELSRPRNGFQAPQPPPPPLSTEAQQEAQQLQRGRRR Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes -------------------------------------------------- Takifugu_rubripes -------------------------------------------------- Capitella_capitata SPAKAKPKGPVGIRAASATRPGPTTSQDDFQVGLQHEDPDHFARVRRGSL Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae STPEARGDGQSFLPNQERDGKNGATS----QVRPANHHADRNQPLGRGHF Hydra_magnipapillata --------------MEVTQKPKSPIP-----------SPNNIRNLSSKII Strongylocentrotus_purpuratus SCGLSVVMESASATELVGSLAAQTIP-----------SHSVVAGVGGAAG Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii -----------MASDVEPGPDNASFVAGPIMTKISPSHADFVAENISFAQ Reniera_sp -------------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans -------------------------------------------------- Drosophila_erecta -------------------------------------------------- Drosophila_melanogaster TSAAAETPAEEMLLSCSATSASLVASTLAERRASRDLRLDLSSTCYGVGG Drosophila_yakuba --YPVIRNHLKLYINGYKKMNMNAFFIILFYDFKKKPQSSNNLTPSQFII Drosophila_sechellia -------------------------------------------------L Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi -------------------------------------------------- Drosophila_ananassae -------------------------------------------------- Drosophila_mojavensis -------------------------------------------------- Drosophila_willistoni -------------------------------------------------- Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis -------------------------------------------------- Anopheles_gambiae -------------------------------------------------- Aedes_aegypti QKDGIGGGKKKDQAKGLDCGLTGGKGDEKQNPLGVNTECKQQQGKSKHLN Bombyx_mori AKKRSRHGKKGHTPS--------------------KDNVDRNVVRRVHYT Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -SRHFGNWYPHPT---VNRPPGVRHDVRLITSFANAPGLLGSQIPLLTHL Schistosoma_japonicum -SRHPGVWYPHPT---ISRPSGARNGVRLTTSFPNVPGLLANRIPLLTHL Echinococcus_multilocularis VSALAEPRFPSPYRWHFHTPAPSRPLFQNGWILRGPPRSYNYVFDPVPHQ Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis LLKDNNSSIACISSRFMTGGKSYWFAEDFPLFSKIQSLLLKMGEGGFVKL Apis_mellifera -------------------------------------------------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum KIKLYPTRKRCVSTSILISASPKKKKKEDQNIIPPKKFLLGGSMSDPLNL Lottia_gigantea -------------------------------------------------- Ixodes_scapularis PKTLKPANNSSRASPLVRKPPPREETASNQNRPPIGGKFVHGGGGNKRRQ Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -------------------------------------------------- Ciona_intestinalis NTGKLEIKCKPIMSAFPVRGKRFHRKRRHSTSEEFPGSINAAKSQNAKHR Ciona_savignyi -------REKPVLNAFSIRGKRLHRKRRHSTSEEFPGNP-ANKPQTAKHR Trichoplax_adhaerens ----------------RVRSLKQHKKKRK-----------LSKDNDDKN- Danio_rerio RRYSMNVAFKHPS-----LGKRRRRANSECDPVLPTNFLLG---GNIFDP Tetraodon_nigroviridis RRNTANSSFKHPS-----SGKRRRRANSESDSVLPTNFLLG---GNIFDP Pan_troglodytes RRNSCNVGGGGGG-FKHPAFKRRRRVNSDCDSVLPSNFLLG---GNIFDP Homo_sapiens RRNSCNVGGGGGG-FKHPAFKRRRRVNSDCDSVLPSNFLLG---GNIFDP Macaca_mulatta RRNSCNVGGGGGG-FKHPAFKRRRRVNSDCDSVLPSNFLLG---GNIFDP Pongo_pygmaeus RRNSCNVGGGGGG-FKHPAFKRRRRVNSDCDSVLPSNFLLG---GNIFDP Canis_familiaris_t2 RRNSCNVGGSGGG-FKHPAFKRRRRVNSDCDSVLPSNFLLG---GNIFDP Canis_familiaris_t1 RRNSCNVGGSGGG-FKHPAFKRRRRVNSDCDSVLPSNFLLG---GNIFDP Equus_caballus RRNSCNVGGGGGG-FKHPAFKRRRRVNSDCDSVLPSNFLLG---GNIFDP Sus_scrofa RRNSCNVGGGGGG-FKHPAFKRRRRVNSDCDSVLPSNFLLG---GNIFDP Felis_catus RRNSCNVGGGGGG-FKHPAFKRRRRVNSDCDSVLPSNFLLG---GNIFDP Loxodonta_africana RRNSCNVGGGGGG-FKHPAFKRRRRVNSDCDSVLPSNFLLG---GNIFDP Mus_musculus RRNSCNVGGGSGGSFKHPAFKRRRRVNSDCDSVLPSNFLLG---GNIFDP Rattus_norvegicus RRNSCNVGGGSGGSFKHPAFKRRRRVNSDCDSVLPSNFLLG---GNIFDP Bos_taurus -------------------------------------------------- Monodelphis_domestica RRNSCNVGG-----FKHPAFKRRRRVNSDCDPVLPSNFLLG---GNIFDP Microcebus_murinus RRNSCNVGGGGGG-FKHPAFKRRRRVNSDCDSVLPSNFLLG---GNIFDP Echinops_telfari RRNSCNVGGGGGG-FKHPAFKRRRRVNSDCDSVLPSNFLLG---GNIFDP Spermophilus_tridecemlineatus RRNSCNVGGGGGG-FKHPAFKRRRRVNSDCDSVLPSNFLLG---GNIFDP Ochotona_princeps RRNSCNVGGGGGG-FKHPAFKRRRRVNSDCDSVLPSNFLLG---GNIFDP Oryctolagus_cuniculus XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPRGHIFDP Dasypus_novemcinctus ---------------------------------LPSNFLLG---GNIFEA Sorex_araneus ----------------------------------PSDGLAS--------- Anolis_carolinensis GLQAPRPSSAAGG------------STRSATRLLLSEFLLG---GNIFDS Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes -------------------------------------------------- Takifugu_rubripes -------------------------------------------------- Capitella_capitata SRKRRSSDKPANLNPFLFNTKKRARARRNSEKEKIVLPSKFLNGGTITDP Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae KRRHASSSHFKRGGPHHLKWR-----RKTVETEPIVLPSDFLLGGNITDP Hydra_magnipapillata SPKLKFDFNYRLNTGVR---------RKCSEKKYHPLKMIFVH-----DP Strongylocentrotus_purpuratus SGRKRHQSTSKAAGQIK---------RRRKTYERNGSKPKFLLGGSITDP Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii PTQPFVSIDNTGTMGINSSDVTSRNDSVMKDIQLLVPEEGKPVPTRKRRH Reniera_sp -------------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans -------------------------NQFHLFCFFAQKFHRHDAMDKIVSP Drosophila_erecta ------------------------------FCFSAQKFHRHDAMDKIVSP Drosophila_melanogaster TGLSFGGSISSSVGSSFGGGGRKRKISESSTSQKSKKFHRHDAMDKIVSP Drosophila_yakuba NGTTSRTTNSSQASFIYFVSLHRNFIVTMPWTRLSVQWFRNQVPGSDRHA Drosophila_sechellia N-TSSRTTNITKTSFIFFFSLHRNFIVTMPWIRLSVQWFRSQVPGSDRHA Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi ------------------------------------KFHRHDAMDKIVSP Drosophila_ananassae -------------------------------------------------- Drosophila_mojavensis ------------------------------------KFHRHDGLDKIVSP Drosophila_willistoni ------------------------------------KFHRHDAMDKIVSP Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis -----------------------------------VPWCHSQGHGSVRHV Anopheles_gambiae -----------------SKFFLPDKRPRKECIVPPTKFLLGGNISDPLNL Aedes_aegypti KNNNSLMQARTKRLQSVSKFFLPDKRPRKDCIIPPTKFLLGGNISDPLNL Bombyx_mori GTKFKQGRKRAQSFPSISKFFLPHKRPRKETFIPPTKFLLGGNISDPLNL Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b A-IRPHHINRVRAKRDNSFTRSRFLNR-RKRSVRASKNTLNPSDPLNLQD Schistosoma_japonicum T-IRPQHIDRIRAKRDQSFTRSRFLNH-RKRNLRPIKSTLNPNDPLNLQD Echinococcus_multilocularis APGRPVRRPISSQSRSSAFRSCKYYAKNRRRCHKTWKPALNPSDPLNLQD Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis IFAREAFYDQALGVLVLCFEVVTHKLKFLAQMSS-TTVDRPAKTGMTNKK Apis_mellifera -------------------------------------------------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum NSLQNEDINKAMNKTPKSSPLHSNTVNIKKDQVN-VIIPRNLSDPLELSK Lottia_gigantea -------------------------------------------------- Ixodes_scapularis SFSVAADYKQPFNKRRRRGDLFTPPTKFLLGGNINDPLNLASFADDEVNK Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -----------MEESNGGSRVDALKMNHPVSIDAQVQTDDGLHREGKSYR Ciona_intestinalis RQGASHHKKEIAGDIILPTNFLLGGNIRDPLNLNSMLDEKVNRALNAVTP Ciona_savignyi KQG-YYHKKEVG-DIILPTNFLLGGNIRDPLNLNSMLDEKVNRALNAVTP Trichoplax_adhaerens ----------------------------DLQTLKKIRQDKVELVETTLKE Danio_rerio LNLNSLLDEEVSKALNAETPKSSPLP-SKNRDPVEILIPKDITDPLNLSG Tetraodon_nigroviridis LNLNSLMDEEVNRALNAETPKSSPLP-ARSRDPVEILIPRDITDPLNLK- Pan_troglodytes LNLNSLLDEEVSRALNAETPKSSPLP-AKGRDPVEILIPKDITDPLSLNT Homo_sapiens LNLNSLLDEEVSRTLNAETPKSSPLP-AKGRDPVEILIPKDITDPLSLNT Macaca_mulatta LNLNSLLDEEVSRALNAETPKSSPLP-AKGRDPVEILIPKDITDPLSLNT Pongo_pygmaeus LNLNSLLDEEVSRALNAETPKSSPLP-AKGRDPVEILIPKDITDPLSLNT Canis_familiaris_t2 LNLNSLLDEEVSRALNAETPKSSPLP-AKGRDPVEILIPKDITDPLSLNT Canis_familiaris_t1 LNLNSLLDEEVSRALNAETPKSSPLP-AKGRDPVEILIPKDITDPLSLNT Equus_caballus LNLNSLLDEEVSRVLNAETPKSSP-------------------------- Sus_scrofa LNLNSLLDEEVSRALNAETPKSSPLP-AKGRDPVEILIPKDITDPLSLNT Felis_catus LNLNSLLDEEVSRALNAETPKSSPLP-AKGRDPVEILIPKDITDPLSLNT Loxodonta_africana LNLNSLLDEEVSRALNAETPKSSPLP-AKGRDPVEILIPKDITDPLSLNI Mus_musculus LNLNSLLDEEVSRALNAETPKSSPLP-AKGRDPVEILIPKDITDPLSLNT Rattus_norvegicus LNLNSLLDEEVSRALNAETPKSSPLP-AKGRDPVEILIPKDITDPLSLNT Bos_taurus -------------------------------------------------- Monodelphis_domestica LNLNSLLDEEVSRALNAETPKSSPLP-AKGRDPVEILIPKDITDPLSLNA Microcebus_murinus LNLNSLLDEEVSRALNAETPKXXXXX-XXXXXXXXXXXXXXXXXXXXXXX Echinops_telfari LNLNSLLDEEVSRALNAETPKSSPLP-AKGRDPVEILIPKDITDPLSLNT Spermophilus_tridecemlineatus LNLNSLLDEEVSRALNAETPKSSPLP-AKGRDPVEILIPKDITDPLSLNT Ochotona_princeps LNLNSLLDEEVSRALNAETPKSSPLP-AKSRDPVEILIPKDITDPLSLNT Oryctolagus_cuniculus LNLNSLLDEEVSRALNAETPKSSPLP-AKGRDPVEILIPKDITDPLSLNT Dasypus_novemcinctus VNLNSLLDEEVSRALNAETPKSSPLP-VKGQDPVEILIPKDITDPLSLNT Sorex_araneus -------------GIAPEN------------------------------- Anolis_carolinensis LNLNSSLGEEVNQGSQRRDLQVVLAAGQRARSRVDLHPPRTSPTSLSLIT Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes -------------------------------------------------- Takifugu_rubripes --PEALNEGFTRRATNQETPQSSPLP-SRGGDPIEILVPRDITDPLNLKG Capitella_capitata LNLSGPGNEALN----ENTPVSSPLPIPVHKSEVKVLLPPNITDPLALNA Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae LNLNSMQDEEVNRMLNAKTPTSSPLPNRTVVGDVGLIIPGDVTDPLHLNQ Hydra_magnipapillata LNLDSLTSKSNGIESPNMR---SPVPDRSCEFQPRLLQPVDLRDPLSLNC Strongylocentrotus_purpuratus LNLNSLDDEEISRIANALTPACSPLPHIDKDPDP-VIVPQDFKDPLKLNI Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii SSHYPAGNHNNSPKFTSPQHIKKRRKTAAITQPMKFLLGGNSTDPLNLNS Reniera_sp -------------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans VVPQPGAWKRPPRILQPSGARKPNTRRSTSVSESELLSPVEELPPKQLPL Drosophila_erecta VVPQPGAWKRPPRILQPSGARKPNSRRSTSVSESELLSPVEEQPPKQLPL Drosophila_melanogaster VVPQPGAWKRPPRILQPSGARKPSTRRSTSVSESELLSPVEEQPPKQLPL Drosophila_yakuba SFNPAGPGSPIPAALRPSANRSCSVLWKSSHPNSCPSSMVSVLFQSLMIQ Drosophila_sechellia SFSPAELGSPTPAALRPSANRSSLVPWKSCRQNSCPSSRVRALSLNLMFL Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi VVPQPGAWKRPQRQLQPSGARKPNTRRSTSFSETELLSPIEELPPKPLPE Drosophila_ananassae -------------------------------------------------- Drosophila_mojavensis VVPQPGAWKRPPRLLQPSGARKPNTRRSTSFSETEQLSPVEELSHKPLVE Drosophila_willistoni VVPQPGAWKRPPRQLQPTGARKPNTRRSTSFSETELPSPIDELPPKALPL Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis CCSPAVPGSPTRDDPRLSAKRNCSAPSRSSRPGSCPSSRVSRSLHPSGPL Anopheles_gambiae NSLQNE----SENAVTPKSSPIPTPPHYKAKIEVIIPPNINDPLHLLDPV Aedes_aegypti NSLQNE----SENAVTPKSSPIPTPPHYKNKIEVIIPPNINDPLHLLDPV Bombyx_mori NSLQDEDVNRAMNAVTPESSPLPTPPRHKAKIDVIIPPNIRDPLNLMEPL Schistosoma_mansoni_a -MKETERRRVEGLSPLRGDSR----------------------------- Schistosoma_mansoni_b LMKETERRRVEGLSPLRGDSR----------------------------- Schistosoma_japonicum LMKETERRRVEGLSPLRGDSR----------------------------- Echinococcus_multilocularis LMKETDRRRIEGLSPPHGDSR----------------------------- Schizosaccharomyces_pombe -MSNFQHGNYHSYYSMRGGTS----------------------------- Nasonia_vitripennis ENENNTKARRISNASHKKHKHEENRHFKFGRKRLQSFTGNGK-------- Apis_mellifera -------------------------------------------------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum CDEAKAIACSGVDSLKPKTPQKSIFKPECNKEKKREVEEEII-------- Lottia_gigantea -------------------------------------------------- Ixodes_scapularis KANEVTPKSSPIPTPKHRTQVEVLIPPNINDPLNLNSGEDIE-------- Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae --MSGFRRGGFRGRKRFYRDN----------------------------- Caenorhabditis_brenneri --MSGFRRGSFRGRKRFYRDN----------------------------- Caenorhabditis_remanei --MSGYRRGGFRGRKRFYKDT----------------------------- Caenorhabditis_elegans --MSSHRRGSFRGRKRFYRDT----------------------------- Caenorhabditis_japonica --MFAHRRGSFRGRKRFHRDT----------------------------- Ancylostoma_canium ----ALKKEGHEQTR----------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi GRGRGHWRGGGRGGRGFKRRTRGDGGPWNKRRRFGYTGTVDD-------- Ciona_intestinalis SSSPLPPRNSTISIVIPNDMTDPLGLNAAPTEEVAENSSLNQ-------- Ciona_savignyi SSSPLPPRSSTINIVIPNDMTDPLGLNSS--NTPTEQSPAEK-------- Trichoplax_adhaerens -------KNSKQKLFIYGNYNRYYGYRNQ--------------------- Danio_rerio RGGDSAAGVLVSPMKIRRRHR----------------------------- Tetraodon_nigroviridis -------------------------------------------------- Pan_troglodytes CTDEGHVVLASPLKTGRKRHR----------------------------- Homo_sapiens CTDEGHVVLASPLKTGRKRHR----------------------------- Macaca_mulatta CTDEGHVVLASPLKTGRKRHR----------------------------- Pongo_pygmaeus CTDEGHVVLASPLKTGRKRHR----------------------------- Canis_familiaris_t2 CTDEAQVVLASPLKTGRKRHR----------------------------- Canis_familiaris_t1 CTDEAQVVLASPLKTGRKRHR----------------------------- Equus_caballus --------------TGRKRHR----------------------------- Sus_scrofa CTDEAQVVLASPLKTGRKRHR----------------------------- Felis_catus CTDEAQVVLASPLKTGRKRHR----------------------------- Loxodonta_africana CTDEAQVVLASPLKTGRKRHR----------------------------- Mus_musculus CTDEAHVVLASPLKIGRKRHR----------------------------- Rattus_norvegicus CTDEAHVVLASPLKIGRKRHR----------------------------- Bos_taurus -------------------------------------------------- Monodelphis_domestica CTDEAQVVRASPLKTGRKRHR----------------------------- Microcebus_murinus XXXXXXXXXXXXXXXXXXXX------------------------------ Echinops_telfari CTDEAQVVLASPLKTGRKRHR----------------------------- Spermophilus_tridecemlineatus CTDEAQVVLASPLKTGRKRHR----------------------------- Ochotona_princeps CTDEAQVVLASPLKTGRTRHR----------------------------- Oryctolagus_cuniculus CTDEAQVVLASPLKTGRKRHR----------------------------- Dasypus_novemcinctus CTDEAQVVLASPLKTGRKRHR----------------------------- Sorex_araneus -------------------------------------------------- Anolis_carolinensis LRRISPCSWSSSAKRKRNRHRGAQEWGQHRGRRLSRSLFGYQ-------- Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes -------------------------------------------------- Takifugu_rubripes GGKEGKDEGGLLLSPLKSRKRHR--------------------------- Capitella_capitata QGESVGLVSPKMGPGKKKKKHRKKKSTDAVEEAESMETSTDV-------- Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae TPRSG---KKRRHKRRRRRSEGDLDDSEHYIDEEATEGITTG-------- Hydra_magnipapillata LDDTAQILTPLRK------------------------------------- Strongylocentrotus_purpuratus TDDNPENNSPLTKTLVPRKSSGKKKKYHNSGEAKRDS------------- Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii LVTGDPCAPVVSPYCSP--------------------------------- Reniera_sp -------------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans IEGKSSIPQSNV-------------------------------------- Drosophila_erecta IDGKSSVPQSN--------------------------------------- Drosophila_melanogaster IG------------------------------------------------ Drosophila_yakuba MXX----------------------------------------------- Drosophila_sechellia XXX----------------------------------------------- Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi GKFQIATWLCHGKNTKIQLFICLQQLLQSSCHATIRPICRSK-ESEVRXX Drosophila_ananassae -------------------------------------------------- Drosophila_mojavensis GKRNKX-------------------------------------------- Drosophila_willistoni IDGRFPR------------------------------------------- Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis TNP----------------------------------------------- Anopheles_gambiae DSVEYEMQLCSPMKRKQRPRNKRKRKSRTTTERNDGLLSIEQLPPPPLGG Aedes_aegypti DSVEYEMQLCSPMKKKQRARNKRKRKSK--SEKNN--------------- Bombyx_mori DNEEYEKRLEMQQRKPKKKTKVRRRTTD---------------------- Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -------------------------------------------------- Schistosoma_japonicum -------------------------------------------------- Echinococcus_multilocularis -------------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis --------FCPPYKRRKKEGAIIPPTKFLLGGNICDPLNLNSMQDEEINR Apis_mellifera -------------------------------------------------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum --------SSPPNKKLKTELLENCMSESENNKVSCEIIEVVETIIDVLVQ Lottia_gigantea ----------------------------------PKEAGRCSMITLRLGD Ixodes_scapularis --------FNLISPRSRKRNRRRSKRKSRSEDDGPEQADASAPAAEVSTD Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae ----------FAPGGSKTDPLNINIELLDDPEAEKKRLGILEPEEVPS-- Caenorhabditis_brenneri ----------FAPGGTKSDPLNINIELTENPEEEKRKLGLLDPEPRHDR- Caenorhabditis_remanei ----------FAPGGSKTDPLNLAIELLDNPEEEKRRLGLLDPEPATVPQ Caenorhabditis_elegans ----------FAPGGSKTDPLNIEIELTENPEEEKKRLGLLDPTTERS-- Caenorhabditis_japonica ----------FAPGGSKTDPLNIEIELSENPEQEKERLGLLPEQQERV-- Ancylostoma_canium ----------VLDIGCTVGFLTLSIAKEYGP---RRILGIDIHN------ Pristionchus_pacificus -------------------------------------------------- Brugia_malayi --------FPFLHGGNSKDPLNLKSVKPVDETENMKPIDIIIPKNIHDPL Ciona_intestinalis --------PSVQKKERERSNSKSRNRKRRKKSLVERTLPDQEDTLQDEGK Ciona_savignyi --------SPSPIPERER--SKSKKRKRRKKSVAERLLP-PEPELEHNLP Trichoplax_adhaerens --------------------STHDGR------------------------ Danio_rerio ------------NRHHPGAT-------TGVADQSDCEKSKTNETTL---- Tetraodon_nigroviridis ---------------------------SGIADSNFLTCPKS--------- Pan_troglodytes ----------HRGQHHQQQQ------AAGGSESHP-VPPTAPLTPS---- Homo_sapiens ----------HRGQHHQQQQ------AAGGSESHP-VPPTAPLTPL---- Macaca_mulatta ----------HRGQHHQQQQ------AAGGSESHP-VLPTAPLTPS---- Pongo_pygmaeus ----------HRGQHHQQQQ------AAGGSESHP-VPATAPLTPS---- Canis_familiaris_t2 ----------HRGQHHQQQQ------ATGGNDSHS-VLPTAPLTPS---- Canis_familiaris_t1 ----------HRGQHHQQQQ------ATGGNDSHS-VLPTAPLTPS---- Equus_caballus ----------HRGQHHQQQQ------ATGGNDSHS-VLPTAPLAPS---- Sus_scrofa ----------HRGQHHQQQQQQQ---ATGGNDSHS-VLPTAPLTPS---- Felis_catus ----------HRGQHHQQQQ------ASGGNDSHS-VLPTAPLTPS---- Loxodonta_africana ----------HRGQHHQQQQ------ASGGNDSHSSVLPPAPLTPS---- Mus_musculus ----------HRGPHHQQQQQ-----ASGGNDSNAAVLPTDPLTPS---- Rattus_norvegicus ----------HRGPHHQQQQ------ASGGNDS-QAVLPTDPLTPS---- Bos_taurus -------------------------------------------------- Monodelphis_domestica ----------HRGQHHQQQAG-----GPGGNDPTSSALPPTSTTPS---- Microcebus_murinus ----------TPGTAHQQQQ------ATGGNDSHS-VLPTAPLTPS---- Echinops_telfari ----------HRGQHHQQQQ------AAGGNDSHSTTLPPTPLTPS---- Spermophilus_tridecemlineatus ----------HRGQHHQQQQ------ASGGNDSH-AMLPTAPLTPS---- Ochotona_princeps ----------HRGQHHQQQQQQAA--AAGGNDSH-PALPAAPLTPS---- Oryctolagus_cuniculus ----------HRGQHHQQQQQQAA--AGGGSDSHS-VPPTAPLTPS---- Dasypus_novemcinctus ----------HRGQHHQQQQ------AAGGNDGHS-VLPTAPLTPS---- Sorex_araneus -------------STTQQQQ-------AGGTDTHX-XXEPEPGCP----- Anolis_carolinensis --------RLARPAEALQQALQXXXRSGGSLLVLGLRLPSASVTGIGGLR Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes -------------------------------------------------- Takifugu_rubripes ----------NRHHGGGDKEMVPARLFPSTSGPAGETQPDPSLGSX---- Capitella_capitata --------TKALTVET------------------PGEPHTSPPAAASAAA Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae --------CKPLVMDSKESFSKEGCPEHIPEGKDKEKERVSPKDKVSPVS Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus --------------------------------------IESLGNSDRDGA Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii ----------APRNKDPNPFLFPKDITDPLNIKSGDDKDNSDPTTVLGPP Reniera_sp -------------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans ----SEVTLNFLFCSGDTPXXXIFCSAVEIPRDDTPDLPDHG-------- Drosophila_erecta ----------------DPDVRSIFCSAVEIPRDDTPDLPDHG-------- Drosophila_melanogaster ---------------------------VEIPRDDTPDLPDHG-------- Drosophila_yakuba -------------------XGSFLCSAVEIPRDDTPDLPDHV-------- Drosophila_sechellia --------------------LQIFFSAVEIPRDDTPDFPDHG-------- Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi XVSNSYLALSRQKYKNTIIYLLAAVVAVELPRDDTPDLSEQG-------- Drosophila_ananassae ---------------ITHISTALLYLLVEIPRDDTPDLPEQS-------- Drosophila_mojavensis -----------XXPIGDTHYNPPFLSVVDIPRDDTPDLSEHG-------- Drosophila_willistoni -------PLWINLGLITIFIIVFCVVLVEIPRDDTPELSEHG-------- Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis ---------------------DFPSIAVNIPRDDTPDLSEQG-------- Anopheles_gambiae EELVGTSSGAASGGGGGGAGGGVAADAEEATTAEEASFTGIGQKLADAAA Aedes_aegypti -QSLDSSAGIAAGG-----QLSTSISEAEATTAEEAQMEAPG-------- Bombyx_mori ----NSSPTKEVSE-------EEVIESIKVPQTPEASMSAQN-------- Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -------------------------------------------------- Schistosoma_japonicum -------------------------------------------------- Echinococcus_multilocularis -------------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis AMNAVTPKSSPLPTPKHRKEAIEVIIPPNICDPLNLINCNDNDEYEKQLI Apis_mellifera -------------------------------------------------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum EVLVSLDECNIPISKAPVEVVVEKILEP----------------CKTLSP Lottia_gigantea VPNNNAIASANQKTQ----------------------------------- Ixodes_scapularis ADASARVASSSSTTASTTTTSRK-----------------------ASSV Nematostella_vectensis --------MSKQ-------------------------------------- Caenorhabditis_briggsae ------------KRRKSDKDDKKDEK------------------------ Caenorhabditis_brenneri -----------PKRRKLDKDDKKQEKAP---------------------- Caenorhabditis_remanei -----------PKRRKTKKKEKKQEKAEE--------------------- Caenorhabditis_elegans ------------KKRKVEKDEKSEKPAE---------------------- Caenorhabditis_japonica ------------KRKRLEKSPVKVFLYN---------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi NLRNVNKNRARRKRRNSKLTEKEEAEGSSESSSKRRGSIASGVNEKRQED Ciona_intestinalis NEPDSITGVLKLDNKCMKVKKNKPSFLVLDGNCDQNSLSVHVPQTSAVTD Ciona_savignyi DE-NEIN-----SNKNMNSKP-----ISINWNCK-----VPRLKKSKVTL Trichoplax_adhaerens -------------------------------------------------- Danio_rerio -----FPVANPEEAANSAVLPPVEE-------------SPRPYELNTSIN Tetraodon_nigroviridis --------------------PTVSP-------------VPWGIQMSTRLK Pan_troglodytes ----LHGEGASQQP----RHRGQNR------------DAPQPYELNTAIN Homo_sapiens ----LHGEGASQQP----RHRGQNR------------DAPQPYELNTAIN Macaca_mulatta ----LHGEGASQQP----RHRGQNR------------DAPQPYELNTAIN Pongo_pygmaeus ----LHGEGASQQP----RHRGQNR------------DAPQPYELNTAIN Canis_familiaris_t2 ----LHGEGTPQQQ----RHRGQNR------------DAPQPYELNTAIN Canis_familiaris_t1 ----LHGEGTPQQQ----RHRGQNR------------DAPQPYELNTAIN Equus_caballus ----LHGEGTTQQQ----RHRGQNR------------DAPQPYELNTAIN Sus_scrofa ----LQGEGTTQQQ----RQRGQNR------------DVPQPYELNTAIN Felis_catus ----LHGEGTTQQQ----RHRGQNR------------DAPQPYELNTAIN Loxodonta_africana ----LHGEGATQQQQQQQRHRGQSR------------DAPQPYELNTAIN Mus_musculus ----LHGEGATQQQ----QNRGQNR------------DAPQPYELNTAIN Rattus_norvegicus ----VHGEGAT--Q----QHRGQNR------------DDPQPYELNTAIN Bos_taurus -------------------------------------------------- Monodelphis_domestica ----LHGEATPQQLQQ--RQKSQGR------------DGPQPYELNTAIN Microcebus_murinus ----LHGEGITQQQQ---RHRGQNR------------DAPQPYELNTAIN Echinops_telfari ----LHGEGAPQQ-----GLRSQNR------------DAPQPYELNTAIN Spermophilus_tridecemlineatus ----LHGEGATQQQ----RHRGQNR------------DAPQPYELNTAIN Ochotona_princeps ----LPRRGAPQQQQ---RHRGQSRXX---------XDAPQPYELNTAIN Oryctolagus_cuniculus ----LHGEGAAQQQ----RPRGQNR------------DAPQPYELNTAIN Dasypus_novemcinctus ----LQGEGTPQQQ----QHRGQNR------------DAPQPYELNTAIN Sorex_araneus ---------------------------------------PSPMNSTQPST Anolis_carolinensis SGGSIEGGGSQGLCSVINGLQGLQKPCNKPCNKPCNGATPQPYELNTIIN Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes ------------------------------------CASPLSCELNTAIT Takifugu_rubripes ------XXHANVFHFCFATVSGLTTGG-------SVSTSPLSCELNTAIT Capitella_capitata ATS-------SSTESLESKLKKIADAIVSP-----------------ALP Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae FSHGHKRTRHNSGRTDDGQVTPVSDTNHTPKRRSKSGEKEMIPMEEIVSP Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus HGDGSSCARPLWLELQNNKMTKLSNKIVSP-----------------VLP Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii KSGGKKKKRHSHRKRSDVGLPRKEGNIDLSSDGSLSEVFEKDANDKEVVS Reniera_sp ----------------------------------LTTSLTX-----REAS Helobdella_robusta -------------------------------------------------- Drosophila_simulans -------------------------------------------------- Drosophila_erecta -------------------------------------------------- Drosophila_melanogaster -------------------------------------------------- Drosophila_yakuba -------------------------------------------------- Drosophila_sechellia -------------------------------------------------- Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi -------------------------------------------------- Drosophila_ananassae -------------------------------------------------- Drosophila_mojavensis -------------------------------------------------- Drosophila_willistoni -------------------------------------------------- Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis -------------------------------------------------- Anopheles_gambiae GEQRFSLPVPDADTGSAHFHLAHFSGQPSTSGTGPVAASSSSVQQGHVHH Aedes_aegypti -------------------------------STGKNVEHSLE-------- Bombyx_mori -------------------------------------------------- Schistosoma_mansoni_a ----MNTPAASVAGDV--------------------------DCGSPQNH Schistosoma_mansoni_b ----MNTPAASVAGDV--------------------------DCGSPQNH Schistosoma_japonicum ----MNTPAASVAGDV--------------------------DCGSPQIQ Echinococcus_multilocularis ----LNTPALSINGEP--------------------------DGTSPN-- Schizosaccharomyces_pombe ----IIDPRLKCLPDS--------------------------LFYEASVL Nasonia_vitripennis SPVKKTSKKRNRKRKRPSSAGRDDTNKESAEIKDSISIEEAKVVENVEAN Apis_mellifera CPFGMFMRGRRRRRR----------------------------------N Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum SPEKKVDDGKETQEQR----------------------EKIKPKRCVVSP Lottia_gigantea ---------------------------------------------KG--- Ixodes_scapularis SAGAQPSFSKEGADKI-----------------------VSPVVPQGSPT Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae -KTGKSP-----------------------------YKKKFQKNHHGSPK Caenorhabditis_brenneri -KNSDTPQGSPQKV-----------YCLSFTKKLSKCSKKFQKNHNGSPK Caenorhabditis_remanei -EETDSPKKSPVKVSFVPFNSIHFVQCIHFITPLLYRFKKFQKNRHGSPK Caenorhabditis_elegans ----NSP---------------------------------FKKNQYNSPR Caenorhabditis_japonica -----FP-----------------------------KKFKFLSEITETPS Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi PIVSPIPLSVVRKFCGNSSRKLSHQKIEKKGRKMQDSTEKLQPSFGTVPG Ciona_intestinalis PIVSPVIPQKTNRNVVFSPKSRKRKASASIHAKNIAQLNMDVVPGTDLLV Ciona_savignyi DLNNEVVKPSLNKN----------------------ALSVTVPQVKKIYC Trichoplax_adhaerens -------------------------------------------------- Danio_rerio CRDEVVQPILPRRKSHP-----------------------SASSSAPQLL Tetraodon_nigroviridis SRASAGHPNRRKRRRN------------------------SGKTEPPVSH Pan_troglodytes CRDEVVSPLPSALQGP------------------------SGSLSAPPAA Homo_sapiens CRDEVVSPLPSALQGP------------------------SGSLSAPPAA Macaca_mulatta CRDEVVSPLPSALQGP------------------------SGSLSAPPAA Pongo_pygmaeus CRDEVVSPLPSALQGP------------------------SGSLSAPPAA Canis_familiaris_t2 CRDEVVSPLPSALQGP------------------------SGSLSAPPAA Canis_familiaris_t1 CRDEVVSPLPSALQGP------------------------SGSLSAPPAA Equus_caballus CRDEVVSPLPSALQGP------------------------SGSLSAPPAA Sus_scrofa CRDEVVSPLPSALQGP------------------------SGSLSAPSAA Felis_catus CRDEVVSPLPSALQGP------------------------SGSLSAPPAA Loxodonta_africana CRDEVVSPLPTALQGS------------------------TGSLSVPPAA Mus_musculus CRDEVVSPLPSALQGS------------------------SGSLSAPPAA Rattus_norvegicus CRDEVVSPLPSALQGS------------------------SGSLSAPPAA Bos_taurus -------------------------------------------------- Monodelphis_domestica CRDEVVSPLLPAPQDP------------------------PGTRATPSTA Microcebus_murinus CRDEVVSPLPSALQGP------------------------SGSLSAPSAA Echinops_telfari CRDEVVSPLPTALQGS------------------------TGCTSLPPAA Spermophilus_tridecemlineatus CRDEVVSPLPSALQGP------------------------SGSLSAPPTA Ochotona_princeps CRDEVVSPLPAALQGP------------------------SGSLSAPSAA Oryctolagus_cuniculus CRDEVVSPLPSALQGP------------------------SGSLPAPPAA Dasypus_novemcinctus CRDEVVSPLPCALQGP------------------------TGSLSALPAA Sorex_araneus AGMRSCRPFRPPCRVS------------------------SGSLSAPPAA Anolis_carolinensis CRDEVVSPLLPAGHGEPPPG----------------HQQVSGGCVTPSCA Gasterostreus_aculeatus ----LAAWTQPPR------------------------------CPLDRCG Oryzias_latipes CREDLAPSPRPSRRHTHPPP----------------GSAHKPGLPADSRQ Takifugu_rubripes CREDIAPPPILPRRHTHPPP----------------GGSIKLGNQRDSRH Capitella_capitata QLSPKLKRGKRTLSES-----------------------SAASG-----R Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae VISPDHEKRRGVEPTR-----------------------IVSRA-----L Hydra_magnipapillata -RRKRKRRFSAGDPYD-----------------------TLS-------- Strongylocentrotus_purpuratus DSRGRKRKASRTEPSS-----------------------RLARALLIDDL Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii QSETMPRQSQRNVDKIV---------------------SPVLDAFDDTSP Reniera_sp CSNRLKKKRQRNRS-------------------------------QSSND Helobdella_robusta -------------------------------------------------- Drosophila_simulans ---------------------------------------------LGSPL Drosophila_erecta ---------------------------------------------LGSPL Drosophila_melanogaster ---------------------------------------------LGSPL Drosophila_yakuba ---------------------------------------------LGSPL Drosophila_sechellia ---------------------------------------------LGSPL Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi ---------------------------------------------VGSPL Drosophila_ananassae ---------------------------------------------LGSPL Drosophila_mojavensis ---------------------------------------------LGSPL Drosophila_willistoni ---------------------------------------------LGSPL Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis ---------------------------------------------LGSPM Anopheles_gambiae VSGAAVMERPGSSAGGLLTEQERERDRVMRNLKLDLESAGGRKRRTSEST Aedes_aegypti ----------GGNTG--------DRDKATRCLRLDLEVC--RKRRISEST Bombyx_mori ----------------------------------------LRKRSCSDSE Schistosoma_mansoni_a GIQTSSASKDSGSPRLSGRKLDCHSKRQSHRLIRRRPMRASK-------- Schistosoma_mansoni_b GIQTSSASKDSGSPRLSGRKLDCHSKRQSHRLIRRRPMRASK-------- Schistosoma_japonicum IIQASSASKGSESPRFISQKSDCPSKRQLHRLVHRRPLRASK-------- Echinococcus_multilocularis IIDPPNSVLSQPSLNLNGKRSSMSFR--CSGLCLRTSRRT---------- Schizosaccharomyces_pombe DIGCNNGTVSAQIASIFG--ASFVLGLDIDHVLIQKAR------------ Nasonia_vitripennis VVVEPAKNESPSKPPPLPPLPSQETQQXXXXXXXXXXXXXXXXXSVLS-- Apis_mellifera KIVSPVIPQPGAWKPRPQHRPSQDKKKKQTMPKFREKDARYQ-------- Tribolium_castaneum ----------------------------------RDYF------------ Acyrthosiphon_pisum VVMQPSLSEKHSVHQQVVVTTAKPKQKVN--KKFKEKNALFK-------- Lottia_gigantea ----------------------------------KKKKPKFI-------- Ixodes_scapularis KFNRRKSSAAGGGASRDVRRSQHQGGRRAKQVYFREKDAHFQ-------- Nematostella_vectensis ----------------------------------KQKGKVFI-------- Caenorhabditis_briggsae K---KAPPLTKEQKD-----AAEFRKNKTEYFNRKYRYGN---------- Caenorhabditis_brenneri KEV-KRPQFSKEEKD-----ASELRKNKTDYFNRKYRYGN---------- Caenorhabditis_remanei KEPRREHQPTKEEKE-----ASEFRKNKNEYFNRKYRYGN---------- Caenorhabditis_elegans KDSRRPPQLSKEEKS-----AAENRKQKTEYFNKKYRYGN---------- Caenorhabditis_japonica SFVERGEGCCRVEKEXXXYFGNIVKNSQRENFEPKYRFPFKQNP------ Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi ASHSQAIEICKVEDEKIAD-EKKKKVEKKARDNQRFRYGN---------- Ciona_intestinalis VASETKETLEKKGAKKSLYSHENESTSEKTCVQYSAVCSPSQNSQKTE-- Ciona_savignyi VYFITLKIWNGNSAGX-------XXIRDAFILQIHQIVARNLNS------ Trichoplax_adhaerens -----LDSWNHQWFQG---------------------------------- Danio_rerio SRSASAP--HPSKHRKRRRTVSRSDSRLSITPTPPTKRL-----ITHT-- Tetraodon_nigroviridis STPVAKS--RPGDRRD----------------TPVGSR--------HS-- Pan_troglodytes SVISAPP-SSSSRHRKRRRTSSKSEAGNRGGGQGSKEK------------ Homo_sapiens SVISAPP-SSSSRHRKRRRTSSKSEAGARGGGQGSKEK------------ Macaca_mulatta SVTSAPP-SSSSRHRKRRRTSSKSEAGARGGGQGSKEK------------ Pongo_pygmaeus SVISAPP-SSSSRHRKRRRTSSKSEAGARGGGQGSKEK------------ Canis_familiaris_t2 SVTSATP-SSSSRHRKRRRTSSKSEAGARGGVQGPKEK------------ Canis_familiaris_t1 SVTSATP-SSSSRHRKRRRTSSKSEAGARGGVQGPKEK------------ Equus_caballus SVTSAPS-SSSSRHRKRRRTSSKSEAGARGAGQGPKEK------------ Sus_scrofa SVTSAPP-SSSSRHRKRRRTSSKSEAGARGGGQGPKEK------------ Felis_catus SVTSAPP-SSSSRHRKRRRTSSKSEAGARGGGQVPKEK------------ Loxodonta_africana SVTPAPP-SSSSRHRKRRRTSSKSEAGARGGGQGPKEK------------ Mus_musculus SVTSAPSTSSSSRHRKRRRTSSKSEAGARGGSQGSKEK------------ Rattus_norvegicus SVTSAPS-SSSSRHRKRRRTSSKSEAGARGGSQGSKEK------------ Bos_taurus -------------------------------------------------- Monodelphis_domestica ATTPAPL-SSSSRHRKRRRTSSKSESGARAGGQGPKEK------------ Microcebus_murinus SVTSAPQ-SSSSRHRKRRRTSSKSEAGARGGSQGSKEK------------ Echinops_telfari SLTPAPTSSSS-RHRKRRRTSSKSEAGARGGGQGPKEK------------ Spermophilus_tridecemlineatus SVTSAPSSSSS-RHRKRRRTSSKSEAGARGGGQGSKEK------------ Ochotona_princeps SVTSAPSSSSSSRHRKRRRTSSKSEVGARGGGQGPKEK------------ Oryctolagus_cuniculus SVTSAPS-SSSSRHRKRRRTSSKSEAGARGGGQGPKER------------ Dasypus_novemcinctus SVTPAPP-SSSSRHRKRRRTSSKSEAGARGGGQGPKEK------------ Sorex_araneus SVASAPP-SSSSRHRKRRRTSSKSEVRARGGGQGAKEK------------ Anolis_carolinensis SVASSAS-ASSRHHRKRRRTCSKSEGAATR--HASTEQ------------ Gasterostreus_aculeatus R------------------------------------------------- Oryzias_latipes RRRRRTTSVHSDPNVATATTITKFQTPLADGAKAGRYG------------ Takifugu_rubripes RRRHRTTSTRS-DIAATAVQPSKFQTPLVGGAKGGRXXXNRALEVCPA-- Capitella_capitata TLSREDSDRSTKAHRRTRYKRQGSNMSTQSAG-PSHQPPR---------- Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae LIENHPSTKEHRSHRRTPDKGRGNHVGSQHKKQPEQGAPS---------- Hydra_magnipapillata FSMTEISPKKSSFKFDTQKNNVCDDLLIRSDPSCVECKKE---------- Strongylocentrotus_purpuratus LPLPPLPKKAKSTEPESKRSGKSPDIVNKLRRQHSHDAKSSR-------- Trichinella_spiralis -----KKEMSKEKSR----------------------------------- Saccoglossus_kowalevskii KLRRKRKDASSKISRSLLRGESGQNEQEVNRTSCKYRRQHSG-------- Reniera_sp QSLPTAPPVSYNAQR----------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans STTSAATSHTAGEQDSLAGVDISVGDAFGSGGVGNAPLTSS--------- Drosophila_erecta STTSAATSHTAGEQDSLAGVDVSMGDASGSGGMGKAPLTSS--------- Drosophila_melanogaster STTSGATSHTAGEQDSLAGVDISMGDTLGSGVVGKAPLTSS--------- Drosophila_yakuba STTSAATSHTAGEQDSLAGVDIIMANASGSGGVGKAPLTSS--------- Drosophila_sechellia STTSAATSHTAGEQDSLAGVDISVGDALGSGGVGNAPLTST--------- Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi SAISAATSHTTGEPEALAADEPATTTAAAALVAAAAAVATSAVAAAAT-- Drosophila_ananassae STTSAATSHTAGEQDSLAGVEATSATDVSAGGSALKPVASSS-------- Drosophila_mojavensis STISAATSHTAGEPDTPSADDATASSTAVAATAGTTAANEGQ-------- Drosophila_willistoni STISAATSQTAGEQDSLVAADAISTTNSEAAQDTQEQA------------ Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis STTSAATSHTAGEQDSLPPDTAAAVEATAESTAAGTAVKPMPEEPT---- Anopheles_gambiae NSTKN----KLRRMDSMDKIVSPVIPQPGGWKRAHWPANAGGSGAAGSAG Aedes_aegypti CSSKN----KVRRMDSMDKIVSPVIPQPGAWKRGHWPAMPVG-------G Bombyx_mori NSSQKGKDKKLRRMDSLDKIVSPVVPQPGAWMRARPQARPAP-------- Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -------------------------------------------------- Schistosoma_japonicum -------------------------------------------------- Echinococcus_multilocularis -------------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis -------------------------------------------------- Apis_mellifera -------------------------------------------------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum -------------------------------------------------- Lottia_gigantea -------------------------------------------------- Ixodes_scapularis -------------------------------------------------- Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -------------------------------------------------- Ciona_intestinalis -------------------------------------------------- Ciona_savignyi -------------------------------------------------- Trichoplax_adhaerens -------------------------------------------------- Danio_rerio -------------------------------------------------- Tetraodon_nigroviridis -------------------------------------------------- Pan_troglodytes -------------------------------------------------- Homo_sapiens -------------------------------------------------- Macaca_mulatta -------------------------------------------------- Pongo_pygmaeus -------------------------------------------------- Canis_familiaris_t2 -------------------------------------------------- Canis_familiaris_t1 -------------------------------------------------- Equus_caballus -------------------------------------------------- Sus_scrofa -------------------------------------------------- Felis_catus -------------------------------------------------- Loxodonta_africana -------------------------------------------------- Mus_musculus -------------------------------------------------- Rattus_norvegicus -------------------------------------------------- Bos_taurus -------------------------------------------------- Monodelphis_domestica -------------------------------------------------- Microcebus_murinus -------------------------------------------------- Echinops_telfari -------------------------------------------------- Spermophilus_tridecemlineatus -------------------------------------------------- Ochotona_princeps -------------------------------------------------- Oryctolagus_cuniculus -------------------------------------------------- Dasypus_novemcinctus -------------------------------------------------- Sorex_araneus -------------------------------------------------- Anolis_carolinensis -------------------------------------------------- Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes -------------------------------------------------- Takifugu_rubripes -------------------------------------------------- Capitella_capitata -------------------------------------------------- Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae -------------------------------------------------- Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus -------------------------------------------------- Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii -------------------------------------------------- Reniera_sp -------------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans -------------------------------------------------- Drosophila_erecta -------------------------------------------------- Drosophila_melanogaster -------------------------------------------------- Drosophila_yakuba -------------------------------------------------- Drosophila_sechellia -------------------------------------------------- Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi --------------------------------------------TAAVAP Drosophila_ananassae -------------------------------------------------- Drosophila_mojavensis -------------------------------------------------- Drosophila_willistoni -------------------------------------------------- Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis -------------------------------------------------- Anopheles_gambiae RNRTRTFSTTSVTDEQHGEDGTIATGADRSTEGQAQEKAHKTERTDGLED Aedes_aegypti RNRTRTQSCTSNSEEPPG-------------------------------- Bombyx_mori PERPVSPHRTKLKSNSEG-------------------------------- Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -------------------------------------------------- Schistosoma_japonicum -------------------------------------------------- Echinococcus_multilocularis -------------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis ---------------------------------YHNLVHGNHDCPIDQIR Apis_mellifera --------------------------------------YGNYN------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum --------------------------------------YGNYT------- Lottia_gigantea --------------------------------------HGNYN------- Ixodes_scapularis --------------------------------------YGNYN------- Nematostella_vectensis --------------------------------------HGNYN------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -------------------------------------------------- Ciona_intestinalis ---------------------------------KKGTNVKSAKPSFKKNN Ciona_savignyi --------------------------------------VNSPT------- Trichoplax_adhaerens -------------------------------------------------- Danio_rerio ---------------------------------QTFHTPVIGGASGAPPL Tetraodon_nigroviridis ---------------------------------QSFHTPRSGPRSGSGAR Pan_troglodytes -------------------------------------GRGSWGGRHH--- Homo_sapiens -------------------------------------GRGSWGGRHH--- Macaca_mulatta -------------------------------------GRGSWGGRHH--- Pongo_pygmaeus -------------------------------------GRGSWGGRHH--- Canis_familiaris_t2 -------------------------------------GRGSGGGRHHHHH Canis_familiaris_t1 -------------------------------------GRGSGGGRHHHHH Equus_caballus -------------------------------------GRGSGGGRH---- Sus_scrofa -------------------------------------GRGSGGGRQ---- Felis_catus -------------------------------------GRGSGGGRHHH-- Loxodonta_africana -------------------------------------GRGSGGGRY---- Mus_musculus -------------------------------------GRGSGGGRH---- Rattus_norvegicus -------------------------------------GRGSGGGR----- Bos_taurus -------------------------------------------------- Monodelphis_domestica -------------------------------------GRASGGGRH---- Microcebus_murinus -------------------------------------GRGSGGGR----- Echinops_telfari -------------------------------------GKGSWGGR----- Spermophilus_tridecemlineatus -------------------------------------GRGSGGGRH---- Ochotona_princeps -------------------------------------GRGSWGGR----- Oryctolagus_cuniculus -------------------------------------GRGSWGGR----- Dasypus_novemcinctus -------------------------------------GRGSGGGRH---- Sorex_araneus -------------------------------------GRGSGGGRH---- Anolis_carolinensis -------------------------------------PPRSSPERAPRSA Gasterostreus_aculeatus ----------------------------------PQHGSAQPVQK----- Oryzias_latipes ----------------------------------SHRGESEKVXXXPLVL Takifugu_rubripes ---------------------------------AQHVLQSDVYAATSRCG Capitella_capitata -------------------------------------------------- Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae -------------------------------------------------- Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus -------------------------------------------------- Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii -------------------------------------------------- Reniera_sp -------------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans ----LMLEP--AKIPPIKKLPKFR-------------------------- Drosophila_erecta ----LTLEP--TMIPPMKMLPKFR-------------------------- Drosophila_melanogaster ----LMLEP--AKIPPIKMLPKFR-------------------------- Drosophila_yakuba ----LMLEP--AMIPPIKMLPKFR-------------------------- Drosophila_sechellia ----LMLEP--AKIPPIKKLPKFR-------------------------- Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi TVLGLMLEP-QIIPPPIHKLPKFR-------------------------- Drosophila_ananassae ----LMLKP-ALIPP-LNHLPKFR-------------------------- Drosophila_mojavensis PVVGLMLEP-ALIPPLHAATPKFR-------------------------- Drosophila_willistoni -IVGIMLEPSSTLIQPQNKLPKFR-------------------------- Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis ----LMLEP--ALIPPLNKLPKFR-------------------------- Anopheles_gambiae HKKQAGDEGGAVKEEGRSNEANVMGTSAGRMGSGIGSIERPLSLTQGTSQ Aedes_aegypti --KQPVLEGEVNTETPQTTEPDIK----------VNNVEQPKSEPSESET Bombyx_mori -------EQQLPTFHPK--------------------------------- Schistosoma_mansoni_a ------CYTVGRCIRGFLPTTGNYCDYYRRRDPND-------------RL Schistosoma_mansoni_b ------CYTVGRCIRGFLPTTGNYCDYYRRRDPND-------------RL Schistosoma_japonicum ------CYTVSRRTRGFIPTTGNYCDYYRRRDPND-------------RL Echinococcus_multilocularis -----------RWQGRRMPLTGNYPDYYSRRDPDD-------------RI Schizosaccharomyces_pombe ----------------------KHLEFVSSRIG----------------- Nasonia_vitripennis IRKRKLNNSQSSIAKMQDSNLEIITRYYGYRNQHQN-------LDTRLTV Apis_mellifera -------------------------RYYGYRNSHNXXX-----MDTRLTV Tribolium_castaneum -------------------------RYYGYRNPHSE-------VDNRLRL Acyrthosiphon_pisum -------------------------RYYGYRNPDDE--------DNRLKV Lottia_gigantea -------------------------RYYGYRNPSDI-------EDIRLEF Ixodes_scapularis -------------------------RYYGYRNNGGQ-------EDPRLKV Nematostella_vectensis -------------------------RYYGYRNNNQS-------EDIRLKS Caenorhabditis_briggsae -----------------------FDRYYGVRLNPGE---------SDKRL Caenorhabditis_brenneri -----------------------FDRYYGIRLNPGE---------RDLRL Caenorhabditis_remanei -----------------------FDRYYGIRLNPGE---------TDKRL Caenorhabditis_elegans -----------------------FDRYYGIRLNPGE---------SDKRL Caenorhabditis_japonica -----------------------LKSIYTYQIQTFL---------SLGVF Ancylostoma_canium ------------------------HLMISSRLVSG--------------- Pristionchus_pacificus -----------------------YDNSFLFRLGVLK---------R---- Brugia_malayi -----------------------YTRYYGSRLEKGSG--------HDPRM Ciona_intestinalis ARFQYGN----------------YSQYYGYRNPKKF---------QDCRM Ciona_savignyi -------------------------------------------------- Trichoplax_adhaerens -------------------------------------------------- Danio_rerio GAERSHEQQR---RPRRKYHNGAYSRYYGYR---------TPSMTADPRL Tetraodon_nigroviridis HHHHHQQQQQPHNQAKKKFQYGNYNKYYGYR---------NPSKSEDPRV Pan_troglodytes --HHHPLPAAGFKKQQRKFQYGNYCKYYGYR----------NPSCEDGRL Homo_sapiens --HHHPLPAAGFKKQQRKFQYGNYCKYYGYR----------NPSCEDGRL Macaca_mulatta --HHHPLPAAGFKKQQRKFQYGNYCKYYGYR----------NPSCEDGRL Pongo_pygmaeus --HHHPLPAAGFKKQQRKFQYGNYCKYYGYR----------NPSCEDGRL Canis_familiaris_t2 HLHLHPLPAAVFKKQQLKFQYGNYCKYYGYR----------NPSCEDGRL Canis_familiaris_t1 HLHLHPLPAAVFKKQQLKFQYGNYCKYYGYR----------NPSCEDGRL Equus_caballus --HLHPLPAAGFKKQQRKFQYGNYSKYYGYR----------NPSCEDGRL Sus_scrofa --HPHPLPAAGFKKQQCKFQYGNYCKYYGYR----------NPSCEDGRL Felis_catus --HLYPLPAAIFKKQQCKFQYGNYCKYYGYR----------NPSCEDGRL Loxodonta_africana --HHHPLPAAGFKKQQRKFQYGNYCKYYGYR----------NPSCEDGRL Mus_musculus --HHHPLPATGFKKQQLKFQYGNYCKYYGYR----------NPSCEDVRL Rattus_norvegicus --HHHPLPATGFKKQQLKFQYGNYCKYYGYR----------NPSCEDMRL Bos_taurus -------------------------------------------------- Monodelphis_domestica --HHHTLPATGFKKQQSKFQYGNYCKYYGYR----------NPNCEDGRL Microcebus_murinus --HHHPLPAAGFKKQQRKFQYGNYCKYYGYR----------NPSCEDGRL Echinops_telfari --HHHPLPAAGFKKQQRKFQYGNYCKYYGYR----------NPSCEDGRL Spermophilus_tridecemlineatus --HHHPLPAAGFKKQHRKFQYGNYSKYYGYR----------NPSCEDGRL Ochotona_princeps ---HHPLPAVGFKTQQRKFQYGNYCEYYGYR----------NPSCEDGRL Oryctolagus_cuniculus ---HHPPPAAAFKKQQRKFQYGNYCEYYGYR----------NPSCEDGRL Dasypus_novemcinctus ---HHPLPAAGFKKQQSKFQYGNYSKYYGYR----------NPSCEDGRL Sorex_araneus --HVHAPPASALKKQQCKFQYGNYCKYYGYR----------NPSCEDGRL Anolis_carolinensis PRSRHPPPASARRQPRHKFQYGNYCKYYGYR----------NPDCEDVRL Gasterostreus_aculeatus ------------KKDRQRYKYGNHSCFYGYQGSYGDAAEGHVGVEEDPRL Oryzias_latipes RCGSAQRPAQPPVKDKFRYQYGNHSRYYGYYGFYG-GRCGRVGVEEDPRL Takifugu_rubripes DVQMGAAQPPQRKKDKRRYHHGQHSCYYGYHGFYGDGREARVGAEEDPRL Capitella_capitata --------VSAGAKRASKFIYGNYDRYYGYRNPDTEF---------DPRL Daphnia_pulex -----------------------YSRYYGYRNPNCE----------DLRL Branchiostoma_floridae --------APHFRPKDQVFQYGNYDRYYGYRNPAKEE---------DVRL Hydra_magnipapillata ------------------------------------------------KT Strongylocentrotus_purpuratus -------HLPKFKEQDKKFQYGNYARYYGYRTPNSD----------DSRI Trichinella_spiralis ------------------FRYGNYTSYYSKRSLSF------DANIADPRL Saccoglossus_kowalevskii ----ENKLLPKCHSKGKLFQYGNYNQYYGKR----------NPEQEDCRL Reniera_sp ----------------AIYRYGNYTQYYGYRNKGA------EPAN-DGRV Helobdella_robusta -------------------------SFHATG------------------- Drosophila_simulans ----------ADGLKYRYGNFD---RYVDFRQMNEFR-------DVRLQV Drosophila_erecta ----------ADGLKYRYGNFD---RYVDFRQMNEFR-------DVRLQV Drosophila_melanogaster ----------ADGLKYRYGNFD---RYVDFRQMNEFR-------DVRLQV Drosophila_yakuba ----------ADGLKYRYGNFD---RYVDFRQMNEFR-------DVRLQV Drosophila_sechellia ----------ADGLKYRYGNFD---RYVDFRQMNEFR-------DVRLQV Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi ----------ADGVKYRYGNFD---RYVDFRQLNEFR-------DVRLQV Drosophila_ananassae ----------ADGLKYRYGNFD---RYVDFRQMNEFR-------DVRLQV Drosophila_mojavensis ----------ADGLKYRYGNFD---RYVDFRHLNEFR-------DVRLQV Drosophila_willistoni ----------ADGLKYRYGNFD---RYVDFRQLNEFR-------DVRLQV Drosophila_pseudoobscura --------------------------------------------DVRLQV Drosophila_persimilis ----------ADGVKYRYGNFD---RYVDFRQLNEFR-------DVRLQV Anopheles_gambiae GTVPPSQSSLAATSRYHFGNYD---RYYGYHSLNEFI-------DVRLKV Aedes_aegypti QAKPKPHE----DSKYHYGNYD---RYYGYRNLNEFI-------DVRLKV Bombyx_mori ------------NSRYQYGNYXXXCRYYGYRNLNAMM-------DIRLQV Schistosoma_mansoni_a PYLMPEWFVGKDVADYG---CHNGTLTFGVLEKFPEVKKIDAFDCDAELI Schistosoma_mansoni_b PYLMPEWFVGKDVADYG---CHNGTLTFGVLEKFPEVKKIDAFDCDAELI Schistosoma_japonicum SYLMPEWFVGKDIADYG---CHNGTLTFGVLEKFPEIKRIDAFDCDAELI Echinococcus_multilocularis KVLMPEWFSNSDVADYG---CHNGTVTFKILEHFPDVNRIDAFDCDAELI Schizosaccharomyces_pombe PVRNPGSIVEDQFNYYP---ISS-------------IKKFSRIPVQLQPP Nasonia_vitripennis FTQRKELFYGKDILDIG---CNIGHITLSVARDF-SARSVTGIDIDKKLI Apis_mellifera FAQRKHLFVGKDVLDIG---CNIGHITLSVARDF-SARSVTGIDIDRTLI Tribolium_castaneum FHQHRYLFEGKDILDIG---CNVGHVTLSVARDF-GAKSVTGIDIDPKLI Acyrthosiphon_pisum LAERTDLFYGKDVLDIG---CNIGHVTFSVARDF-GAKSVVGMDIDRKLI Lottia_gigantea FD--IEWFKGKDVLDIG---CNVGHLTILVAKKL-SPKMIVGIDIDSSLI Ixodes_scapularis MQ--ASWLDGKDVLDIG---CNVGHFTLSLARGF-SPRKVIGLDIDGRLI Nematostella_vectensis FK--KEWFQGKDVLDIG---CNTGIVTLAIAKNY-EPRVIVGSDIDNSLI Caenorhabditis_briggsae TVFDKQWFEHKQILDIG---CNVGFLTLSIAKDF-SPRRILGIDIDEHLI Caenorhabditis_brenneri SVLNKEWFEHKQILDIXXXGCNVGFVTLSIAKDF-APRRILGIDIDEHLI Caenorhabditis_remanei SAFDKAWFEHKSILDIXXXGCNVGFLTLSIAKDF-SPRRILGIDIDEHLI Caenorhabditis_elegans SVFQKDWFEHKQALDIG---CNAGFLTLSIAKDF-SPRRIIGIDIDEHLI Caenorhabditis_japonica LTLFSKISVNTFFANLLQLGCNVGFLTLSIAKDF-MPRRILGIDIDEHLI Ancylostoma_canium -------FIATNILSLLER---FPLLSAKFLTNF-LPYTFILHPLPGPLL Pristionchus_pacificus -----EWFEKRSVLDIG---CNAGFLTLSLAK------------------ Brugia_malayi KVLKKEWFEKKSVLDIG---CNVGYLTLSIAKEY-QPRNIVGIDIDAHLV Ciona_intestinalis TCLKREWFKEKDVLDVG---CNVGHLTLLIARDY-SPRKIVGIDIDGSLI Ciona_savignyi --------TEKDVLDVG---CNVGHLTLLIARDY-SPRKIVGVDIDATLI Trichoplax_adhaerens ----------KDCLDIG---CNDGHLTIEIAKKF-NPNTIVGIDIDASLI Danio_rerio ALFNPEWFSGKKVLDVG---CNTGHVTLAIAKHC-SPAHILGLDIDGALV Tetraodon_nigroviridis HFLRREWFEGKDVLDLG---CNLGHLTLYIAKMH-RPARILGLDIDGALV Pan_troglodytes RVLKPEWFRGRDVLDLG---CNVGHLTLSIACKW-GPSRMVGLDIDSRLI Homo_sapiens RVLKPEWFRGRDVLDLG---CNVGHLTLSIACKW-GPSRMVGLDIDSRLI Macaca_mulatta RVLKPEWFRGRDVLDLG---CNVGHLTLSIACKW-GPSRMVGLDIDSRLI Pongo_pygmaeus RVLKPEWFRGRDVLDLG---CNVGHLTLSIACKW-GPSRMVGLDIDSRLI Canis_familiaris_t2 RVLKPEWFRGRDVLDLG---CNVGHLTLSIACKW-GPSRMVGLDIDSRLI Canis_familiaris_t1 RVLKPEWFRGRDVLDLG---CNVGHLTLSIACKW-GPSRMVGLDIDSRLI Equus_caballus RVLKPEWFRGRDVLDLG---CNVGHLALSIACKW-GPSRMVGLDIDARLI Sus_scrofa RVMKPEWFRGRDVLDLG---CNVGHLTLSIACKW-GPSRMVGLDIDPHLI Felis_catus RVLKPEWFRGRDVLDLG---CNVGHLTLSIACKW-GPSLMVGLDIDSRLI Loxodonta_africana RVLKPEWFRGRDVLDLG---CNVGHLTLSIACKW-GPSRMVGLDIDARLI Mus_musculus RVLKPEWFQGRDVLDLG---CNVGHLTLSIACKW-GPARMVGLDIDPRLI Rattus_norvegicus RVLKPEWFQGRDVLDLG---CNVGHLTLSIACKW-GPARMVGLDIDPRLI Bos_taurus ---------------------------------------MVGLDIDAQLI Monodelphis_domestica RVMRPEWFQGRDVLDLG---CNVGHLTLSIACKW-GPARVVGVDIDARLI Microcebus_murinus RVLKPEWFRGRDVLDLG---CNVGHLTLSIACKW-GPSRMVGLDIDARLI Echinops_telfari RVLKPEWFRGRDVLDLG---CNVGHLTLSIACKW-GPSRMVGLDIDARLI Spermophilus_tridecemlineatus RVLKPEWFRGRDVLDLG---CNVGHLTLSIACKW-GPSRMVGLDIDPRLI Ochotona_princeps RVMKAEWFRGRDVLDLG---CNVGHLTLSIACKW-SPSRMVGLDIDPQLI Oryctolagus_cuniculus RVLKPEWFRGRDVLDLG---CNVGHLTLSIACKW-GPSRMVGLDIDSQLI Dasypus_novemcinctus RVLKPEWFRGRDVLDLG---CNVGHLTLSIACKW-GPSRMVGLDIDPWLI Sorex_araneus RVLKPEWFRGRDVLDLG---CNVGHLTLSIACKW-GPSRMVGLDIDPQLI Anolis_carolinensis RVMKPEWFQGKEVLDVG---CNVGHFTLSVAKKW-GPARMVGLDIDGHLI Gasterostreus_aculeatus HLLQADWFRDKKVLDVG---CGAGHLTLAVARRF-DPAHILGLDLDRQLV Oryzias_latipes RLLAADWFRDKTVLDVG---CGAGHITLAVARKF-NPSHILGVELDQHLV Takifugu_rubripes RLLEADWFRDKKVLDVG---CGAGHLTLAVARKF-NPSHILGVELDEQLV Capitella_capitata QCLQSDWFENRHVLDVG---CNVGHLTLAIARDL-KPKRIVGIDIDHKLI Daphnia_pulex RSFWREWFEDKDVLDIG---CNAGHVTLCVARDF-NPKQIVGIDIDPKLI Branchiostoma_floridae SYFRPDWFKNLDVLDIG---CNAGHLTLSIARDY-APRKIVGMDIDQNLI Hydra_magnipapillata SFVKKDIYR-----NIG---CNNGKVTLEILKRF-DPSFITGVDIDDRLI Strongylocentrotus_purpuratus DFFKREWFEGKNCLDIG---CNSGHVTLAIAKLF-DPSKIVGVDIDGNLI Trichinella_spiralis NLLEKEWFFNKNVLDIG---CNSGQLTLAVGKKF-SPNVIVGIDIDSALI Saccoglossus_kowalevskii KCFCTEWFRGKDVLDIG---CNIGHVTLTIAKDF-EPRKITGIDIDGNLI Reniera_sp KLLQEEWFRDKTVLDIG---CNTGLLTIAVASLF-SPYKITGIDIDKKLI Helobdella_robusta GLATQEIISRQEVLEIG---CNSAFVSIKLSKDF-MAKKVLALDINEKLV Drosophila_simulans FQRHVELFENKDILDIG---CNVGHMTITVARHL-APKTIVGIDIDRELV Drosophila_erecta FQRHVELFENKDILDIG---CNVGHMTITVARHL-APKTIVGIDIDRELV Drosophila_melanogaster FQRHVELFENKDILDIG---CNVGHMTITVARHL-APKTIVGIDIDRELV Drosophila_yakuba FQRHVELFENKDILDIG---CNVGHMTITVARHL-APKTIVGIDIDRELV Drosophila_sechellia FQRHVELFENKDILDIG---CNVGHMTITVARHL-APKTIVGIDIDRELV Drosophila_virilis -----ELFQNKDILDIG---CNVGHMTITVARHL-APKSILGIDIDRELI Drosophila_grimshawi FERHAELFQNKDILDVG---CNVGHMTITVARHL-APKSILGIDIDQELV Drosophila_ananassae FQRHVELFQNKDILDIG---CNVGHMTITVARHL-APKTIMGIDIDRELV Drosophila_mojavensis FEQHVELFQNKDILDIG---CNVGHMTITVARHL-APKSILGIDIDRKLI Drosophila_willistoni FQRHPELFQNKDILDIG---CNVGHMTITVARHL-APKTILGIDIDRELV Drosophila_pseudoobscura FQRHVELFQNKDILDIG---CNVGHMTITVARHL-APKTILGIDIDRELV Drosophila_persimilis FQRHVELFQNKDILDIG---CNVGHMTITVARHL-APKTILGIDIDRELV Anopheles_gambiae FMRNAYLFRDKDVLDIG---CNVGLMTIAIAKSL-HTKSAIGIDVDGKLI Aedes_aegypti FLRNPYLFRDKDVLDIG---CNVGLMTIAVAKML-HTKSITGIDIDEKLI Bombyx_mori FEMHRHLFQNKDVLDIG---CNVGHISIAVARTF-GARSVVGIDIDSVLI Schistosoma_mansoni_a AN---AQSMQREKLRWDIESNVR--------------------------- Schistosoma_mansoni_b AN---AQSMQREKLRWDIESNVR--------------------------- Schistosoma_japonicum AN---AQSMQREKLRWDTGSNVR--------------------------- Echinococcus_multilocularis EN---AKSLQREKIRWAAQTSAN--------------------------- Schizosaccharomyces_pombe LN---KQNFPHN-------------------------------------- Nasonia_vitripennis NI---ARKNVKHYVNCHN-------------------------------- Apis_mellifera NI---ARKNIKHYVNCVQSP------------------------------ Tribolium_castaneum SI---ARKNVKYYVKNSDSPK----------------------------- Acyrthosiphon_pisum NI---ARKNVQYYINDTAQSSSYLSSNYHFKD------------------ Lottia_gigantea SA---ARKNIRYYVEAQEK------------------------------- Ixodes_scapularis KA---ARRNVRHYLTAALA------------------------------- Nematostella_vectensis RI---AKSNIRNYVEKPISST----------------------------- Caenorhabditis_briggsae GV---ARKNIRHYCDHET-------------------------------- Caenorhabditis_brenneri GV---ARKNIRHYCDHET-------------------------------- Caenorhabditis_remanei GV---ARKNIRHYCDHET-------------------------------- Caenorhabditis_elegans GV---ARKNIRHYCDHET-------------------------------- Caenorhabditis_japonica GV---ARKNIRHYCDHETNVSSTITETFXXXSVWHAKIFATIVIMRQML- Ancylostoma_canium DS---KGE----LCTGEXX------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi GV---ARKNIRHYCDNDVP------------------------------- Ciona_intestinalis NI---ARTNIRHYATASVR------------------------------- Ciona_savignyi SI---ARTNIRHYATAGVRCVFVLLWFIFCFQDENTQXXXNYDVT----- Trichoplax_adhaerens TR---ARSNITRIN------------------------------------ Danio_rerio QA---ARQNLRHFLSELQDRQQAGAGEGSEVTGLVPLMDLQLVLP----- Tetraodon_nigroviridis HA---ARKNIRHYLSELQAQEARHTAEEREQDDGPPAATDVSESC----- Pan_troglodytes HS---ARQNIRHYLSEELRLPPQTLEGDPGAEGEEGT-TTVRKRS----- Homo_sapiens HS---ARQNIRHYLSEELRLPPQTLEGDPGAEGEEGT-TTVRKRS----- Macaca_mulatta HS---ARQNIRHYLSEELRLPPQTVEGDPGAEGEEGT-TTVRKRS----- Pongo_pygmaeus HS---ARQNIRHYLSEELRLPPQTLEGDPGAEGEEGT-TTVRKRS----- Canis_familiaris_t2 HS---ARQNIRHYLSEELRLPSQTSEGDPGAESEEGT-ITVRKRS----- Canis_familiaris_t1 HS---ARQNIRHYLSEELRLPSQTSEGDPGAESEEGT-ITVRKRS----- Equus_caballus HS---ARQNIRHYLSEELRLPPQTSEGDPGAESEEGT-TTVRKRS----- Sus_scrofa HS---ARQNIRHYLSEELRQPPQTSEGDPGTEGEEGT-STVQKRS----- Felis_catus HS---ARQNIRHYLSEELRLPPQTSEGDPGAESEEGT-TTVRKRS----- Loxodonta_africana HS---ARQNIRHYLSEELRLPPQTPEGDPGAEGGEGT-TTIRKRS----- Mus_musculus HS---ARQNIRHYLSEELRLQAQTSEGDPGTEGEEGT-ITVRKRS----- Rattus_norvegicus HS---ARQNIRHYLSEELRLQAQTSEGDPGTEGEEGT-TTVRKRS----- Bos_taurus HS---ARQNIRHYLSEELRLPPQTSEGSPGAESEEGT-TAIRKRS----- Monodelphis_domestica HS---ARQNIRHYLSEELRLTPQSPEGVQGPEGGKGT-ATTRKKS----- Microcebus_murinus HS---ARQNIRHYLSEELRLPPQNSEGDPGAEGEEGT-TTVRKRS----- Echinops_telfari HS---ARQNIRHYLSEEFRLPPQTPEGDPVAEGREGT-TTIRKRS----- Spermophilus_tridecemlineatus HS---ARQNIRHYLSEELRLLPQTSEGDPGADGEEGT-ATVRKRS----- Ochotona_princeps HS---ARQNIRHYLSEELRLPTQTSEGDPGAEGKEGTPTTVRKRS----- Oryctolagus_cuniculus HS---ARQNIRHYLSEELRLPTQTSERDPGAEGKEGT-TTVRKRG----- Dasypus_novemcinctus HS---ARQNIRHYLSEELGLPPQTPEGDLEAEGGEET-TTIRKRS----- Sorex_araneus HS---ARQNIRHYLSEQLRLPPQTAEGNPGTES-EGA-ASVPERN----- Anolis_carolinensis HS---ARQNIRHYLSEELHQQKQQ-------QSDEGP--SPGARK----- Gasterostreus_aculeatus HA---AKQNIRHFLSHDLVVEERRGAQRA---SSPSRTGEEGQQA----- Oryzias_latipes HA---AKQNIRHFLSHDTVVAQRSGE-------------EEG-------- Takifugu_rubripes HA---AKQNIRHFLSHDLVVTERNGPTPAPTSSCPSRTVEEGGGTGKVAA Capitella_capitata SG---AKKNVRHLLSKAVADIA---------------------------- Daphnia_pulex SI---ARKNIKTYSSSHPTER----------------------------- Branchiostoma_floridae RV---ARRNIRHYLAPEARDS----------------------------- Hydra_magnipapillata KL---ARSYARNDSYMPSRQR----------------------------- Strongylocentrotus_purpuratus GV---ARKNVKNCLEEQFREKRGKGC------------------------ Trichinella_spiralis GH---ARRNQRLAMDKNLLSKMN--------------------------- Saccoglossus_kowalevskii SI---ARKNIRHYLSP-AWSFMG--------------------------- Reniera_sp RM---AWKNLYRGKVS-IVTPAG--------------------------- Helobdella_robusta KA---SRSNLNDWSNLSSRKSTSSQP------------------------ Drosophila_simulans AR---ARRNLSIFVRIPKEE--------KLQE----VKAEPTVDAKAN-- Drosophila_erecta AR---ARRNLSIFVRIPTEE--------KLLD----VKVEPTIEAKAELS Drosophila_melanogaster AR---ARRNLSIFVRIPKEE--------KLLE----VKAEPTVDAKAN-- Drosophila_yakuba AR---ARRNLSIFVRIPTEE--------KLQEPTIDAKPELSPPEKTE-- Drosophila_sechellia AR---ARRNLSIFVRIPKEE--------KLQE----VKAEPMVDAKAN-- Drosophila_virilis AR---ARRNLSIFVRIPKEE-------LLAPE----IKQEAGVQAQAQS- Drosophila_grimshawi SR---ARRNLSIFVRIPREEEHEKVAEIKQED----IKKELQQQQQQQSH Drosophila_ananassae AR---ARRNLSIFVRIPKEE--------KPPE----VKVEPSPQDKQDE- Drosophila_mojavensis AR---ARRNLSIFVRIPEED-------RLVPE----TKQLQS-QSKPDK- Drosophila_willistoni AR---ARRNLSIFVRIPKEEK------RLLQD----IKTELQMPQQPMAI Drosophila_pseudoobscura GR---ARRNLSIFVRIPKEEK-------VKME----VKQEPTSQLVKSE- Drosophila_persimilis GR---ARRNLSIFVRIPKEEK-------VKME----VKQEPTSQLVKSE- Anopheles_gambiae AK---ARKNLAKYVRVPRTVV-----------------PGAGRRAPPEPP Aedes_aegypti AK---ARRNLTTHVRIQ---------------------PGHAKHG----- Bombyx_mori GXXXRARKNLQSFVAVPPPEP-----------------PKTDCDKKTDVE Schistosoma_mansoni_a --------------------YEKINFQVAN-------------------- Schistosoma_mansoni_b --------------------YEKINFQVAN-------------------- Schistosoma_japonicum --------------------YEKINFQVAN-------------------- Echinococcus_multilocularis --------------------FEKINFQVAD-------------------- Schizosaccharomyces_pombe -----------------------IEFETAD-------------------- Nasonia_vitripennis -------------------------------------------------- Apis_mellifera --------AGNEDSDHQDVNFFPISMPINYGPVDIPGFTKDK-------- Tribolium_castaneum -----SERVGEVPVNKKSSEFFPISMPILYGPIDIPGFNDGQ-------- Acyrthosiphon_pisum -----FAPRNRNDSNSDIIESFPISLPMLYGPINLAGLT----------- Lottia_gigantea -----------------EKPVFPVSNNVVFGPMEAPPLIKCSR------- Ixodes_scapularis -----------------GEMRFPVSMAICHGPIAAAALPGRE-------- Nematostella_vectensis ---------------TIASTQFPISFMLTSGPLAAPVLSSND-------- Caenorhabditis_briggsae ----------------EVAGKFPASFGVQFGTISQRTEAPRS-------- Caenorhabditis_brenneri ----------------AVAGKFPASFGVQFGTISQKTEEPRS-------- Caenorhabditis_remanei ----------------AVAGKFPVSFGVQFGTISQRTEEPRP-------- Caenorhabditis_elegans ----------------EVSGKFPASFGVQFGTVSQRNEAPRS-------- Caenorhabditis_japonica ----VQPLLKLSKVFLQVAGKFPASFGTQLGPISQQTEAPRS-------- Ancylostoma_canium ----------------XVYWKGSRFFLPNFSPISSHT---LS-------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -----------------IVAGFPASFAQRYGPVSAP---LTT-------- Ciona_intestinalis -------------PPSQLASSFPDSMPKMYGPLVAPPVETGKD------- Ciona_savignyi -----MCFTQHPRPPSPLASSYPESMAKMFGPIVAPPVETGTD------- Trichoplax_adhaerens ---------------STKNHQFPISFGICHGPIVD----TCND------- Danio_rerio --------------------RFPVSFMRCRGPIAAPPIMHQS-------- Tetraodon_nigroviridis --------------------SFPVSLQISRGPIAAPPLTEAST------- Pan_troglodytes --------------------CFPASLTASRGPIAAPQVPLDG-------- Homo_sapiens --------------------CFPASLTASRGPIAAPQVPLDG-------- Macaca_mulatta --------------------CFPASLTASRGPIAAPQVPLDG-------- Pongo_pygmaeus --------------------CFPASLTASRGPIAAPQVPLDG-------- Canis_familiaris_t2 --------------------CFPASLTASRGPIAAPQVPLDG-------- Canis_familiaris_t1 --------------------CFPASLTASRGPIAAPQVPLDG-------- Equus_caballus --------------------CFPASLTASRGPIAAPQVPLDG-------- Sus_scrofa --------------------CFPASLTASRGPIAAPQVPLDG-------- Felis_catus --------------------CFPASLTASRGPIAAPQVPLDG-------- Loxodonta_africana --------------------CFPASLTASRGPIAAPQVPLDG-------- Mus_musculus --------------------CFPASLTASRGPIAAPQVPLDG-------- Rattus_norvegicus --------------------CFPASLTASRGPIAAPHLPLDG-------- Bos_taurus --------------------YFPASLTASRGPIAAPQVPLDG-------- Monodelphis_domestica --------------------CFPASLTASRGPIAAPQVPLDG-------- Microcebus_murinus --------------------CFPASLTASRGPIAAPKXXXVG-------- Echinops_telfari --------------------CFPASLTASRGPIAAPQVPLDG-------- Spermophilus_tridecemlineatus --------------------CFPASLTASRGPIAAPQLPLDG-------- Ochotona_princeps --------------------YFPASLTAIRGPIAAPQVPLDG-------- Oryctolagus_cuniculus --------------------YFPASLTASRGPIAAPQVPLDG-------- Dasypus_novemcinctus --------------------CFPASLTASRGPIAAPQVPLDG-------- Sorex_araneus --------------------CFPASLTASRGPIAAPQVPLDG-------- Anolis_carolinensis --------------------TFPASLMASRGPIAAPRVPQEG-------- Gasterostreus_aculeatus ----------------LPLLPLPLSFRVSRGPLSAPP-LLPSS------- Oryzias_latipes ------------------LTPFPLSFRVSRGPICGPS-LLPSS------- Takifugu_rubripes AEGMQADHVQEFQRALSLLNSFPLSLRASRGPLSAPPLLLPPS------- Capitella_capitata --------------------SFPASLSLVHGPIAAPPLMSCKE------- Daphnia_pulex --------------------QFPVSMPLMYGSIPS------TH------- Branchiostoma_floridae ---------------------FPVSMAIQYGPMAAGG----LV------- Hydra_magnipapillata ---------------------FPVSIKQTYGPMLNTR----IL------- Strongylocentrotus_purpuratus -------------------VDFPVSLQKTYGPLAPAA----ST------- Trichinella_spiralis -------------------LKFPSSFSRTYGPLSAPPEPK---------- Saccoglossus_kowalevskii -------------------QKFPISMDRCHGPIAAPPIPQSG-------- Reniera_sp -------------------QPFPKSLTMRYLPPAKDLVTSSSEVMRNIEF Helobdella_robusta -------------------SLYPEHFSKSFGSMCHPLLNLDLTCHEWTN- Drosophila_simulans -------------IMAKDETSGAAHKKTRRGKRRRKVHQG---------- Drosophila_erecta PP-------GKTEISAKAEASGAAHKKTRRGKRRRKVHEG---------- Drosophila_melanogaster -------------IAVKDETSGAAHKKTRRGKRRRKVHQG---------- Drosophila_yakuba -------------IVAKVEASRAANKKTRRGKRRRKVDEG---------- Drosophila_sechellia -------------IMAKDESSGAAHKKTRRGKRRRKVHQG---------- Drosophila_virilis ------------VPEKLEPSDANAHKKTRRGKKRRKAQQQQQQLALQQLH Drosophila_grimshawi LA-------SDKLAESGEESNAMLHKKTRRGKKRRRAQQQQQQLQLQQQQ Drosophila_ananassae -----------------GAASKAAHKKTRRGKKRRAAQQ----------- Drosophila_mojavensis ------------------AEPGDGHKKTRRGKKRRKAQQHLKQLQ----- Drosophila_willistoni EK-------TEPIEE--SSTSGQTHKKTRRARKRRKAQQ----------- Drosophila_pseudoobscura -----------PMDDGEEAAAGSLHKKTRRGKKRRKALQDQQQ------- Drosophila_persimilis -----------PMDDGEEAAAGSLHKKTRRGKKRRKALQDQQQ------- Anopheles_gambiae A----------------IAVPAETSNRVVARQKRRRKRFGQKG------- Aedes_aegypti ---------------------GETK---LSGEKRKR-RISRK-------- Bombyx_mori DK-------KIDCNKCHQEKCDDFCEQKEKADDPKKTIPGRKL------- Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -------------------------------------------------- Schistosoma_japonicum -------------------------------------------------- Echinococcus_multilocularis -------------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis -------------------------------------------------- Apis_mellifera -------------------------------------------------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum -------------------------------------------------- Lottia_gigantea -------------------------------------------------- Ixodes_scapularis -------------------------------------------------- Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -------------------------------------------------- Ciona_intestinalis -------------------------------------------------- Ciona_savignyi -------------------------------------------------- Trichoplax_adhaerens -------------------------------------------------- Danio_rerio -------------------------------------------------- Tetraodon_nigroviridis -------------------------------------------------- Pan_troglodytes -------------------------------------------------- Homo_sapiens -------------------------------------------------- Macaca_mulatta -------------------------------------------------- Pongo_pygmaeus -------------------------------------------------- Canis_familiaris_t2 -------------------------------------------------- Canis_familiaris_t1 -------------------------------------------------- Equus_caballus -------------------------------------------------- Sus_scrofa -------------------------------------------------- Felis_catus -------------------------------------------------- Loxodonta_africana -------------------------------------------------- Mus_musculus -------------------------------------------------- Rattus_norvegicus -------------------------------------------------- Bos_taurus -------------------------------------------------- Monodelphis_domestica -------------------------------------------------- Microcebus_murinus -------------------------------------------------- Echinops_telfari -------------------------------------------------- Spermophilus_tridecemlineatus -------------------------------------------------- Ochotona_princeps -------------------------------------------------- Oryctolagus_cuniculus -------------------------------------------------- Dasypus_novemcinctus -------------------------------------------------- Sorex_araneus -------------------------------------------------- Anolis_carolinensis -------------------------------------------------- Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes -------------------------------------------------- Takifugu_rubripes -------------------------------------------------- Capitella_capitata -------------------------------------------------- Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae -------------------------------------------------- Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus -------------------------------------------------- Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii -------------------------------------------------- Reniera_sp VEVR---------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans ----------------------------------IHHHHHHHH--DLEQL Drosophila_erecta ----------------------------------IHHHHHHHHH-DLEQL Drosophila_melanogaster ----------------------------------IHHHHHHHH--DLEQL Drosophila_yakuba ----------------------------------IXXXXXXXXXXDIEQL Drosophila_sechellia ----------------------------------IHHHHHHHH--DLEQL Drosophila_virilis AHG---------------HHPHHPHHPHHPHHYHHHNHHHHHHHHHHHQH Drosophila_grimshawi QQQQQQQQQQQLALQQLQHHHHHHHHHHHPHQHDHHHHHHHHHHHHHDHD Drosophila_ananassae --------------------PLHPHPHPHPHPHPHHPHHHHHGHHHHHHV Drosophila_mojavensis --------------------LQQQLALQHLQQFHHHHHHHHHHHHSHDHH Drosophila_willistoni ----------------------QQHQQQQLLQQNHHQHHHHHHHHDH--- Drosophila_pseudoobscura --------------------LLHPNHHHHHHPHPHHHHPHHHHHHHHHHH Drosophila_persimilis --------------------LLHPSHHHHHHPHPHHHHPHHHHHHHHHHH Anopheles_gambiae ------------------------------------GRHGQHHNSQHHQQ Aedes_aegypti ------------------------------------LTTGEEKSLVKEEE Bombyx_mori ------------------------------------KKPRKNRKSFYKHE Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -------------------------------------------------- Schistosoma_japonicum -------------------------------------------------- Echinococcus_multilocularis -------------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis -----------------------DHKGFPYN--------VTFVQ------ Apis_mellifera -----------------------SHKGFPYN--------VNFVQVSYXXX Tribolium_castaneum -----------------------TGRDFPNN--------VVFKTVIVEX- Acyrthosiphon_pisum -----------------------LSGRFPYN--------VSFVQ------ Lottia_gigantea ----------------------SESSIFPQN--------IVFKQ------ Ixodes_scapularis ----------------------SEPVTFPNN--------VFFVQ------ Nematostella_vectensis ----------------------LSTCSFPKN--------VVFKQ------ Caenorhabditis_briggsae -----------------------FSTKFPDN--------IWFKK------ Caenorhabditis_brenneri -----------------------FSTKFPDN--------IWFKK------ Caenorhabditis_remanei -----------------------FSTKFPDN--------VWFKK------ Caenorhabditis_elegans -----------------------FSTKFPDN--------IWFKK------ Caenorhabditis_japonica -----------------------FSTKFPDN--------IWFKK------ Ancylostoma_canium -----------------------FSTHFPDH--------CWIQK------ Pristionchus_pacificus -------------------------VRFPSN--------HNX-------- Brugia_malayi -----------------------FSTKFPDN--------IWFRC------ Ciona_intestinalis -----------------------DSAEFPNN--------VLFFEG----- Ciona_savignyi -----------------------DSARFPNN--------ILFFEXXX--- Trichoplax_adhaerens -----------------------DSTLYPRN--------ILFKQE----- Danio_rerio ------------------------LGQFPSN--------VCFLK------ Tetraodon_nigroviridis ----------------------VRPGEFPSN--------VSFIK------ Pan_troglodytes ----------------------ADTSVFPNN--------VVFVT------ Homo_sapiens ----------------------ADTSVFPNN--------VVFVT------ Macaca_mulatta ----------------------ADTSVFPNN--------VVFVT------ Pongo_pygmaeus ----------------------ADTSVFPNN--------VVFVTVRGSRG Canis_familiaris_t2 ----------------------ADTSVFPNN--------VVFVT------ Canis_familiaris_t1 ----------------------ADTSVFPNN--------VVFVT------ Equus_caballus ----------------------ADTSVFPNN--------VVFVT------ Sus_scrofa ----------------------ADTSVFPNN--------VVFVTVRRSAG Felis_catus ----------------------ADTSVFPNN--------VVFVTVRGSEG Loxodonta_africana ----------------------ADTSVFPNN--------VVFVTVRGSXX Mus_musculus ----------------------ADTSVFPNN--------VVFVT------ Rattus_norvegicus ----------------------ADTSVFPNN--------VVFVT------ Bos_taurus ----------------------ADTAVFPNN--------VVFVT------ Monodelphis_domestica ----------------------ADASIFPNN--------VVFIT------ Microcebus_murinus ----------------------YVEAVVLVIP------LLTFPTS----- Echinops_telfari ----------------------ADTSVFPNN--------VVFVTVRGSXX Spermophilus_tridecemlineatus ----------------------ADTSVFPNN--------VVFVRVRRSXX Ochotona_princeps ----------------------TDSS-FPNN--------VVFVTVSGVG- Oryctolagus_cuniculus ----------------------ADSSVFPNN--------VVFVTVRGSER Dasypus_novemcinctus ----------------------ADMTVFPNN--------VVFVTVR-VRR Sorex_araneus ----------------------SDTSVFPHN--------VVFVTVRGXXX Anolis_carolinensis ----------------------TDASVFPNN--------VIFIKVRQGGD Gasterostreus_aculeatus ----------------------SSSSRFPNN--------VTFIQVS-LPR Oryzias_latipes ----------------------SSS-RFPHN--------VTFIQVSPAPT Takifugu_rubripes ----------------------SSSSRFPNN--------VTFIQVSLILF Capitella_capitata ----------------------QKATSEQ------FPHNVMFMQXXX--- Daphnia_pulex ----------------------SSASSSR------FPGNVSFVQ------ Branchiostoma_floridae ----------------------GDQVATQ------FPNNVFFTQVSQSLI Hydra_magnipapillata ----------------------QHGLSG----------NICFIT------ Strongylocentrotus_purpuratus ----------------------SSSVGRRTPGTSLFPANILFRC------ Trichinella_spiralis -----------------------FTKKFPEN--------VFFKVFTLFDS Saccoglossus_kowalevskii ---------------------MDHTPRFPNN--------VMFRCVSKQCF Reniera_sp ---SLLLEFCLGLAETSNFGWNEVLVKYXXX--------WMYQQYTPTPV Helobdella_robusta ---------------HVKDEVDDDCLKFPHN--------IHFKCVSLKDF Drosophila_simulans Q-------QQQKLNSLLVKPHEFFPISFPLTYGRIPH--VLLSSKSPNVL Drosophila_erecta Q-------QQHKLNLLLVKPHEFFPISFPLTYGGIPN--VLSSSKSPNML Drosophila_melanogaster Q-------QQQKLNSLLVKPHEFFPISFPLTYGRIPR--ILSSSKSPNML Drosophila_yakuba Q-------QQHKLNSLLVKPHEFFPISFPLTYGSIPH--FLASSKSPSML Drosophila_sechellia Q-------QQQKLNSLLVKPHEFFPISFPLTYGRIPH--VLLSSKSP-ML Drosophila_virilis QHNHLDLQQQQKLDALLVKPHEFFPISFPLTYGGIPH--LPATGKSPATF Drosophila_grimshawi HDHLLDVQQQLKLDSLLVKPHEFFPISFPLTYGGIPHLLLPPTGKSPANL Drosophila_ananassae EQ----LQQQERLDALLVKPHEFFPISFPLTYGGIPN--LPSSGKSPN-- Drosophila_mojavensis H-----LEQQQKLDALLVKPHEFFPISFPLTYGGMPH--LPPTGKSPLNF Drosophila_willistoni --------QQEKLDALLVKPHEFFPISFPLTYGGMPN--LPTSEKSPCNA Drosophila_pseudoobscura HQNQEQLQQQLKLDALLVKPHEFFPISFPLTYGGMPQLPPPPAGKSPNLS Drosophila_persimilis HQNQEQLQQQLKLDALLVKPHEFFPISFPLTYGGMPQLPLPPAGKSPNLS Anopheles_gambiae H-------QQHHLRRNKPEQSQYFPISFPVTMG-------NFSGKEHQMD Aedes_aegypti A-------PHEEKPAEVPDTAESMPK--PETS----------SAKKGQHP Bombyx_mori Q-------GQSFFPMSMSMLYGPIRDLLPELLT-------FPHNVTFKHV Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -------------------------------------------------- Schistosoma_japonicum -------------------------------------------------- Echinococcus_multilocularis -------------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis -------------------------------------------------- Apis_mellifera ICIH---------------------------------------------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum -------------------------------------------------- Lottia_gigantea -------------------------------------------------- Ixodes_scapularis -------------------------------------------------- Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -------------------------------------------------- Ciona_intestinalis -------------------------------------------------- Ciona_savignyi -------------------------------------------------- Trichoplax_adhaerens -------------------------------------------------- Danio_rerio -------------------------------------------------- Tetraodon_nigroviridis -------------------------------------------------- Pan_troglodytes -------------------------------------------------- Homo_sapiens -------------------------------------------------- Macaca_mulatta -------------------------------------------------- Pongo_pygmaeus SWN---------------------------------------------RG Canis_familiaris_t2 -------------------------------------------------- Canis_familiaris_t1 -------------------------------------------------- Equus_caballus -------------------------------------------------- Sus_scrofa LGX---------------------------------------------XX Felis_catus SWD---------------------------------------------RG Loxodonta_africana X------------------------------------------------- Mus_musculus -------------------------------------------------- Rattus_norvegicus -------------------------------------------------- Bos_taurus -------------------------------------------------- Monodelphis_domestica -------------------------------------------------- Microcebus_murinus -------------------------------------------------- Echinops_telfari XEC---------------------------------------------QR Spermophilus_tridecemlineatus -------------------------------------------------- Ochotona_princeps -------------------------------------------------- Oryctolagus_cuniculus LLXXXHQE----------------------------------------EA Dasypus_novemcinctus LLGX---------------------------------------------- Sorex_araneus -------------------------------------------------- Anolis_carolinensis SRLYNHRI----------------------------------------LE Gasterostreus_aculeatus TAQ----------------------------------------------- Oryzias_latipes SSA----------------------------------------------- Takifugu_rubripes SSR----------------------------------------------- Capitella_capitata -------------------------------------------------- Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae LQISYNSRILDSSTEEFFLARKKDNVTVYSHSAFGSNNHIYSFXXXHDEK Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus -------------------------------------------------- Trichinella_spiralis RKTTVG-------------------------------------------- Saccoglossus_kowalevskii CXXXSCNY------------------------------------------ Reniera_sp KLNSTNIKN----------------------------------------- Helobdella_robusta NSFLISSLX----------------------------------------- Drosophila_simulans GSK----------------------------------------------- Drosophila_erecta GNK----------------------------------------------- Drosophila_melanogaster GNK----------------------------------------------- Drosophila_yakuba GNK----------------------------------------------- Drosophila_sechellia GNK----------------------------------------------- Drosophila_virilis AAG----------------------------------------------- Drosophila_grimshawi LLSSSSLSSSN--------------------------------------- Drosophila_ananassae TAS----------------------------------------------- Drosophila_mojavensis N------------------------------------------------- Drosophila_willistoni SSSS---------------------------------------------- Drosophila_pseudoobscura PNK----------------------------------------------- Drosophila_persimilis PNK----------------------------------------------- Anopheles_gambiae IGRP---------------------------------------------- Aedes_aegypti HRR----------------------------------------------- Bombyx_mori NTHL---------------------------------------------- Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -------------------------------------------------- Schistosoma_japonicum -------------------------------------------------- Echinococcus_multilocularis -------------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis -----------------------------------------------GNY Apis_mellifera ---------------------------------------------FQGNY Tribolium_castaneum ---------------------------------------------XXCNY Acyrthosiphon_pisum -----------------------------------------------GNY Lottia_gigantea -----------------------------------------------GNY Ixodes_scapularis -----------------------------------------------GNY Nematostella_vectensis -----------------------------------------------ENY Caenorhabditis_briggsae -----------------------------------------------ENY Caenorhabditis_brenneri -----------------------------------------------ENY Caenorhabditis_remanei -----------------------------------------------ENY Caenorhabditis_elegans -----------------------------------------------ENY Caenorhabditis_japonica -----------------------------------------------ENY Ancylostoma_canium -----------------------------------------------ENY Pristionchus_pacificus -------------------------------------------------X Brugia_malayi -----------------------------------------------ENY Ciona_intestinalis ------------------------------------------------NY Ciona_savignyi -----------------------------------------------GNY Trichoplax_adhaerens ------------------------------------------------NY Danio_rerio -----------------------------------------------GDY Tetraodon_nigroviridis -----------------------------------------------ANY Pan_troglodytes -----------------------------------------------GNY Homo_sapiens -----------------------------------------------GNY Macaca_mulatta -----------------------------------------------GNY Pongo_pygmaeus QVXXXSEKNVARAKVSRRTVSAQSRLPGSRGSLI-PSVDLTADSCPQGNY Canis_familiaris_t2 -----------------------------------------------GNY Canis_familiaris_t1 -----------------------------------------------GNY Equus_caballus -----------------------------------------------GNY Sus_scrofa MRL----------------------------------LTSPLTLHPQGNY Felis_catus QVXXXR---------------LQGGLCGGSGSFI-ASVDLAPNSCPQGNY Loxodonta_africana -----------------------------------SSVDLISNYCPQGNY Mus_musculus -----------------------------------------------GNY Rattus_norvegicus -----------------------------------------------GNY Bos_taurus -----------------------------------------------GNY Monodelphis_domestica -----------------------------------------------GNY Microcebus_murinus --------------------------------------------CLQGNY Echinops_telfari GWRPE-------------PCHRCERSDGDSGSSH-LLVDLTPNSCPQGNY Spermophilus_tridecemlineatus -------------------XRAIVRASGDSFPS----VDFTRNSCPQGNY Ochotona_princeps ------------------VILGGMRLKGVWQXX------XPPTLAHRVTM Oryctolagus_cuniculus GTGRWKGGKGGSMGPVGSVGEPGCRGLCGAVAPF-MPLLTSPQFCPQGNY Dasypus_novemcinctus --------XXGDLGLQVFVLEASDGVEWGPWFFF-SPVDLTPNSCSQGNY Sorex_araneus --------GWWRPWMEVPLLPVPEMLVGAVGLPV-PLLNPSPHPGPQGNY Anolis_carolinensis LEERDLVGHPVQPHCAKKQENCIQKHRHPSSVXXXVCLIFFPSLSPQGNY Gasterostreus_aculeatus -----------------------------LHPVEL----LXXXLLPQGDY Oryzias_latipes -----------------------------LNLVVSSCIHLXXXLLPQGDF Takifugu_rubripes -----------------------------RDVSRTN---IRAELLRQGNY Capitella_capitata -----------------------------------------------GNY Daphnia_pulex -----------------------------------------------GNY Branchiostoma_floridae IIMSRIAFWKGTILGPVTHFKVRTFRCLVSNFNHMTTVLTKCCDIFQANY Hydra_magnipapillata -----------------------------------------------QNY Strongylocentrotus_purpuratus -----------------------------------------------ANF Trichinella_spiralis ---------------------------------LVNFTVLFFLXXXQMNY Saccoglossus_kowalevskii -------------------------------KLLYNFLLVYFCLFFQCNY Reniera_sp -------------------SYMGTKSQNIIPANFSSYTVFHYATFFRVIT Helobdella_robusta ----------------------------------------XXKRLFQADY Drosophila_simulans ------------------------------------NQFPANVFFRHTNY Drosophila_erecta ------------------------------------NPFPANVFFRHTNY Drosophila_melanogaster ------------------------------------NQFPANVFFRHTNY Drosophila_yakuba ------------------------------------NQFPANVFFRHTNY Drosophila_sechellia ------------------------------------NQFPANVFFRHTNY Drosophila_virilis ----------------------------------CKNQFPQNVFFRQTNY Drosophila_grimshawi ----------------------------------CKNQFPQNVFFRRTNY Drosophila_ananassae -----------------------------------KNQFPANVFFRHTNY Drosophila_mojavensis ----------------------------------CKNQFPQNVFFRQTNY Drosophila_willistoni ----------------------------------TKNQFPQNVFFRYTNY Drosophila_pseudoobscura ------------------------------------NQFPANVFFRQTNY Drosophila_persimilis ------------------------------------NQFPANVFFRQTNY Anopheles_gambiae -----------------------------------ENKFPNNVRFKTMNY Aedes_aegypti -------------------------------------KFPG--------- Bombyx_mori -----------------------------------LYYFYNYPFDFFCCS Schistosoma_mansoni_a --WIDES-----------TTNDEPEYDTIMAFSVTKWIHLNHGDP---GL Schistosoma_mansoni_b --WIDES-----------TTNDEPEYDTIMAFSVTKWIHLNHGDP---GL Schistosoma_japonicum --WIDES-----------STNDEPEYDTIMAFSVTKWIHLNHGDP---GL Echinococcus_multilocularis --WSDCT-----------STDDDPTYNIILAFSVTKWIHLNYGDA---GL Schizosaccharomyces_pombe --FLRWE-----------SKR---KFKIILALSVSKWVHLNNHDE---GI Nasonia_vitripennis ILEDDAL-----------LSSEQPQFDTIICLSITKWIHLNFGDA---GL Apis_mellifera VLEDDSL-----------LCTEQPQFDAILCLSITKWIHLNFGDA---GL Tribolium_castaneum VLDDDSL-----------LALEQPQFDVILCLSITKWIHLNWGDS---GM Acyrthosiphon_pisum VLESDLL-----------LSLETCKFDVILCLSITKWLHLNWGDD---GL Lottia_gigantea VLENEDQ-----------LSLVKEEYDTILALSISKWIHLNNGDE---GI Ixodes_scapularis ILESDVL-----------LEAQREEFDTILCLSLTKWVHLNWGDE---GV Nematostella_vectensis VPPHETA-----------LSYQKAMYDTILCLSVTKWVHLNNGDQ---GL Caenorhabditis_briggsae VMENDEM-----------LDMIQPEFDVILALSITKWIHLNWGDD---GM Caenorhabditis_brenneri VLENDEM-----------LDMIQPEFDVILALSITKWIHLNWGDD---GM Caenorhabditis_remanei VLESDEM-----------LDMIQPEFDVILALSITKWIHLNWGDN---GL Caenorhabditis_elegans VLESDEM-----------LDMIQPEFDVILALSITKWIHLNWGDD---GM Caenorhabditis_japonica VLESDEL-----------LDMIQPEFDVILALSITKWIHLNWGDD---GM Ancylostoma_canium VLENDEL-----------LETLHDDFDVFLPLSITKGIHLIYGDD---GL Pristionchus_pacificus XMNTFE---------------VEEEYDVILALSITKWIHLNWGDD---GM Brugia_malayi VLEKDEL-----------LDAVKEEYDVIMALSITKWIHLNWGDA---GI Ciona_intestinalis VPEVDEI-----------LRFQEPEYDVIMCMSVTKWMHMNWGDE---GL Ciona_savignyi VPEVDEI-----------LRFQEPEYDVIMCMSVTKWMHMNWGDA---GI Trichoplax_adhaerens IKESMES-----------INEEKPLYDVILCLSLTKWIHLNWGDE---GV Danio_rerio VPDSDAE-----------VVSQSAEYDVILCLSLTKWVHLNYGDA---GI Tetraodon_nigroviridis VLDNDNL-----------LLTQRQEYDVILCLSVTKWVHLNWGDN---GL Pan_troglodytes VLDRDDL-----------VEAQTPEYDVVLCLSLTKWVHLNWGDE---GL Homo_sapiens VLDRDDL-----------VEAQTPEYDVVLCLSLTKWVHLNWGDE---GL Macaca_mulatta VLDRDDL-----------VEAQTPEYDVVLCLSLTKWVHLNWGDE---GL Pongo_pygmaeus VLDRDDL-----------VEAQTPEYDVVLCLSLTKWVHLNWGDE---GL Canis_familiaris_t2 VLDRDEL-----------VEAQTPEYDVVLCLSLTKWVHLNWGDE---GL Canis_familiaris_t1 VLDRDEL-----------VEAQTPEYDVVLCLSLTKWVHLNWGDE---GL Equus_caballus VLDRDEL-----------VDAQNPEYDVVLCLSLTKWVHLNWGDE---GL Sus_scrofa VLDRDEL-----------VEAQKPEYDVVLCLSLTKWVHLNWGDE---GL Felis_catus VLDRDEL-----------VEAQTPEYDVVLCLSLTKWVHLNWGDE---GL Loxodonta_africana VLDRDEL-----------VEAQTPEYDVVLCLSLTKWVHLNWGDE---GL Mus_musculus VLDRDEL-----------VDAQRPEYDVVLCFSLTKWVHLNWGDE---GL Rattus_norvegicus VLDRDEL-----------VDAQRPEYDVVLCFSLTKWVHLNWGDE---GL Bos_taurus VLDRDEL-----------VEAQKPEYDVVLCLSLTKWVHLNWGDE---GL Monodelphis_domestica VLDRDEL-----------VEAQAPEYDVVLCLSLTKWVHLNWGDE---GL Microcebus_murinus VLDRDEL-----------VEAQTPEYDVVLCLSLTKWVHLNWGDE---GL Echinops_telfari VLDRDEL-----------VEAQAPEYDVVLCLSLTKWVHLNWGDE---GL Spermophilus_tridecemlineatus VLDRDEL-----------VEAQKPEYDVVLCLSLTKWVHLNWGDE---GL Ochotona_princeps CWTEMSW-----------WRPRKPSMTWCSASASLKWVHLNWGDE---GL Oryctolagus_cuniculus VLDRDEL-----------VEAQKAEYDVVLCLSLTKWVQLNWGDE---GL Dasypus_novemcinctus VLDRDEL-----------VDAQAPEYDVVLCLSLTKWVHLNWGDE---GL Sorex_araneus VLDREEL-----------VDAQAPEYDVVLCLSLTKWVHLNWGDE---GL Anolis_carolinensis VLERDEL-----------LEAQRPEYDVILCLSLTKWVHLNWGDE---GL Gasterostreus_aculeatus VSRGNWW-----------PG--RGQYDIILCLGVTKWVQLQAGDG---GV Oryzias_latipes IAGREAW-----------PG--RGQYDVIMCLGLTKWVHLHSGDE---GV Takifugu_rubripes VSSQHKW-----------PG--RGQYDVIVCLGVTKWVHLHSGDV---GV Capitella_capitata VMEKDEQ-----------VERQQEEYDAILFFSISKWIHLNWGDA---GL Daphnia_pulex VPESDEF-----------LQMVQPEYDAILCLSVTKWIHLNWKDA---GL Branchiostoma_floridae VPDSDSR-----------VQSQQPEYDVILALSLTKWIHLNWGDA---AM Hydra_magnipapillata VPCELDD-----------LSKIKEEYDTITCLSVTMWVQLNFGDS---GL Strongylocentrotus_purpuratus VLEKDSM-----------LETQREEYDTILCLSVTKWIHLNWGDA---GM Trichinella_spiralis VLSSDAF-----------LEYEKAEYDTVMAFSITKWIHLNWGDE---GI Saccoglossus_kowalevskii VLETDAL-----------LSLQRPEYDVIMCLSVSKWIHLNFGDE---GL Reniera_sp YQAAMTK-----------YLHYRPVYDVLMCMSVTKWIHLNWGDDXXXGI Helobdella_robusta VPTSQLE-----------IKNETPQYDVIVALGVTKYIHLNYGDE---GL Drosophila_simulans VLKDES-----------LMASDSQQYDLILCLSVTKWIHLNFGDN---GL Drosophila_erecta VLKDES-----------LMASDSQQYDLILCLSVTKWIHLNFGDN---GL Drosophila_melanogaster VLKDES-----------LMASDTQQYDLILCLSVTKWIHLNFGDN---GL Drosophila_yakuba VLKDES-----------LTASDSQQYDLILCLSVTKWIHLNFGDN---GL Drosophila_sechellia VLKDES-----------LMASDSQQYDLILCLSVTKWIHLNFGDN---GL Drosophila_virilis VLKDES-----------LMSNDTQQYDLILCLSVTKWMHLNFGDA---GL Drosophila_grimshawi VLKDEA-----------LMSHDSQQYDLILCLSVTKWMHLNFGDA---GL Drosophila_ananassae VLKDES-----------LMANDSQQYDLILCLSVTKWMHLNFGDA---GL Drosophila_mojavensis VLKDES-----------LMSNDTQQYDLILCLSVTKWIHLNFGDA---GL Drosophila_willistoni VLKDES-----------LMANDTQQYDLILCLSVTKWIHLNFGDA---GL Drosophila_pseudoobscura VLKDES-----------MMANDTQQYDLILCLSVTKWIHLNFGDA---GL Drosophila_persimilis VLKDES-----------MMANDTQQYDLILCLSVTKWIHLNFGDA---GL Anopheles_gambiae VLKDEQ-----------MINFDTQQYDLILCLSVTKWIHLNYGDV---GL Aedes_aegypti -----------------------------------------RHGH---GK Bombyx_mori FLMLXXXGNYVPREDLAVGSGESPQFDLILCLSTTKWMHLNWGDA---GL . . Schistosoma_mansoni_a MRFFRRA---FNRLKPG---GHLILEPQPKSSYKRTRLT----------- Schistosoma_mansoni_b MRFFRRA---FNRLKPG---GHLILEPQPKSSYKRTRLT----------- Schistosoma_japonicum MRFFRRA---FNCLKPG---GHLILEPQPKSSYKRTRLTVSIHFLK---- Echinococcus_multilocularis MRFFRRV---FNLLKPG---GHLLLEPQPKASYKNSRFTVRVKFFSSLM- Schizosaccharomyces_pombe IKFFGKI---SSLLETN---GVLILEPQGWDSYLKAAKKIS--------- Nasonia_vitripennis KQSFKRM---HAQLRPG---GVLILEPQSWNSYSKKK------------- Apis_mellifera KQAFKRM---YAQLRPS---GVLILEPQGWSSYTKKKNLTVSIPFQFIYA Tribolium_castaneum KQAFRRM---YAQLRPG---GKLILEPQNWASYKSKRKLTVGTHQKFFFH Acyrthosiphon_pisum KRAFKRM---FAQLRPG---GILVVEPQPWKSYSRRK------------- Lottia_gigantea KIFFKRI---HKHLRPG---GRLILEPQPWASYKKRK------------- Ixodes_scapularis RRLFKRM---FRQLRPG---GRMLLEAQPFHSYVKKK------------- Nematostella_vectensis KLMFKKM---FKNLRPG---GKLILEPQPMSSYKRRK------------- Caenorhabditis_briggsae RRFFKRA---FAQLHPG---GRLIIEPQAFETYRKRAKMS---------- Caenorhabditis_brenneri RRFFKRA---YAQLHPGXXXGRFIIEPQLFESYRKRAKMN---------- Caenorhabditis_remanei MRFFKRA---YAQLHPGXXXGRFIIEPQAFETYRKRAKMN---------- Caenorhabditis_elegans RRFFRRA---YAQLHPG---GRLIIEPQAFDSYKKRAKMS---------- Caenorhabditis_japonica RRFLKRA---YAQLHPGXXXGRLIIEPQSFETYRKRAKMN---------- Ancylostoma_canium RRFCLRP---YYHLLPD---GRFVVEPPPFASYRKRSKMT---------- Pristionchus_pacificus RRFFKRLXXXFASLLPG---GRFILEPQHFSTYRKRSVMSXX-------- Brugia_malayi KRFFKRV---YRHLRPG---GLFILEPQSFETYKKRSKLTASSLSIAYA- Ciona_intestinalis KKTFERF---FKQLRAG---GKLIIEPQEWKSYGKKKKLT---------- Ciona_savignyi KKTFERF---FKQLRAG---GKLILEPQDWKSYGKKKKLTVSFVYFWYFF Trichoplax_adhaerens KKLFKRI---FMNLRHD---GILILEPQSIESYKKKKRLS---------- Danio_rerio QRLFGRI---YRHLLPG---GVLILEPQPWSSYSRHKRLT---------- Tetraodon_nigroviridis KRLFKRA---YRHLRSG---GLFILEPQPWESYVRRKKLTVGDEIHLSFH Pan_troglodytes KRMFRRI---YRHLRPG---GILVLEPQPWSSYGKRKTLT---------- Homo_sapiens KRMFRRI---YRHLRPG---GILVLEPQPWSSYGKRKTLT---------- Macaca_mulatta KRMFRRI---YRHLRPG---GILVLEPQPWSSYGKRKTLT---------- Pongo_pygmaeus KRMFRRI---YRHLRPG---GILVLEPQPWSSYGKRKTLTVSWVLGGIVI Canis_familiaris_t2 KRMFRRI---YRHLHPG---GILVLEPQPWSSYSKRKTLT---------- Canis_familiaris_t1 KRMFRRI---YRHLHPG---GILVLEPQPWSSYSKRKTLT---------- Equus_caballus KRMFRRI---YRHLRPG---GILVLEPQPWSSYGRRKTLT---------- Sus_scrofa KRMFRRI---YLHLRPG---GILVLEPQPWSTYGKRKTLTVSWGFCGNC- Felis_catus KRMFRRI---YRHLRPG---GILVLEPQPWSSYGKRKTLSVSXXX----- Loxodonta_africana KRMFRRI---YRHLRPG---GILVLEPQPWSSYGKRKTLTVSXXX----- Mus_musculus KRMFRRI---YRHLRPG---GILVLEPQPWSSYCKRKSLT---------- Rattus_norvegicus KRMFRRI---YRHLRPG---GILVLEPQPWSSYCRRKSLT---------- Bos_taurus KRMFRRI---YRHLRPG---GILVLEPQPWSSYGRRKTLT---------- Monodelphis_domestica KRMFRRI---YRHLRPG---GILVLEPQPWSSYGKRKTLT---------- Microcebus_murinus KRMFRRI---FRHLRPG---GILVLEPQPWSSYGKRKTLTXXX------- Echinops_telfari KRMFRRI---YRHLRPG---GILVLEPQPWSSYGKRKTLTVSSVWVEMGG Spermophilus_tridecemlineatus KRMFRRI---YRHLRPG---GILVLEPQPWSSYXXXXXXXXXXXXXXXXX Ochotona_princeps KRMFRRI---YRHLRPG---GILVLEPQPWSSYNKRKTLTVSRVACPWDS Oryctolagus_cuniculus KRMFRRI---YRHLRPG---GILVLEPQPWSSYNKRKTLTVSRVS----- Dasypus_novemcinctus KRMFRRI---YRHLRPG---GILVLEPQPWSSYGRRKTLTVSWAXXX--- Sorex_araneus KRMFRRI---YRHLHPG---GILVLEPQPWSSYGKRKTLT---------- Anolis_carolinensis KRLFKRI---YRHLRPG---GILVLEPQAWSSYKKRKNLTVRHHSP---- Gasterostreus_aculeatus VALFRRA---YQSLSPG---GLFMLEPQPWSSYSHSKGASVSLFYTLN-- Oryzias_latipes VRLFRRT---YQSLSPG---GVLILEPQPWSSYSRSKRVTVRLPAAPRXX Takifugu_rubripes VRLFTRA---YQSLSPG---GLFILEAQPWSSYSRSRGASVR-------- Capitella_capitata KRAFRRV---FKQLRPG---GHFILEPQSWTSYKRRTKLNVWF------- Daphnia_pulex KRFFQRI---FAHLRPG---GRLILEAQGWASYNKRKKLTVS-------- Branchiostoma_floridae KRTFQRV---FRQLRPG---GRFIVEPQPWKSYGRKKKLTVIDTP----- Hydra_magnipapillata KRMFKKI---FMQLKPG---GKLLLEPQLLKSYKKKKNLSLKT------- Strongylocentrotus_purpuratus KRFFKRI---FRALHPG---GRLILEPQAWPSYQKKRKMTVGD------- Trichinella_spiralis KRFFKRV---YLNLKPG---GRLLLEPQAFSSYAKRR------------- Saccoglossus_kowalevskii KRAFKRV---YLQLRPG---GRFIFEPQSWQSYSKKKKLTVSKICVQI-- Reniera_sp KRLFKKI---YQELKLN---GILILEPQPWSSYAKRKK------------ Helobdella_robusta KRTFQKI---YRQLRPG---GRFIMQAQRWSTYKKKKRIN---------- Drosophila_simulans KMAFKRM---FNQLRPG---GKLILEAQNWASYKKKK-------NLTX-- Drosophila_erecta KMAFKRM---FNQLRPG---GKLILEAQNWASYKKKK-------NLTVSY Drosophila_melanogaster KMAFKRM---FNQLRPG---GKLILEAQNWASYKKKK-------NLTP-- Drosophila_yakuba KMAFKRM---FNQLRPG---GKLILEAQNWASYKKKR-------NLTV-- Drosophila_sechellia KMAFKRM---FNQLRPG---GKLILEAQNWASYKKKK-------NLTV-- Drosophila_virilis KLAFKRI---FNQLRPG---GKLILEAQNWASYKKKK-------NLTVSF Drosophila_grimshawi KLAFKRM---FNQLRPG---GKLILEAQNWASYKKKK-------NLTVSD Drosophila_ananassae KTAFKRM---FNQLRPG---GKLILEAQNWASYKKKK-------NLTVSH Drosophila_mojavensis KLAFKRI---FNQLRPG---GKLILEAQNWASYKKKK-------NLTVWL Drosophila_willistoni KLAFKRM---FNQLRPG---GKLILEAQNWASYKKKK-------NLTVSF Drosophila_pseudoobscura KLAFKRM---FNQLRPG---GKLILEAQNWASYKKKK-------NLTVSD Drosophila_persimilis KLAFKRM---FNQLRPG---GKLILEAQNWASYKKKK-------NLTVSD Anopheles_gambiae KTAFKRM---FNHLRPG---GKLILEAQNWASYKKKKKLTE--------- Aedes_aegypti HHMHNHH---HNHQRK---------------------------------- Bombyx_mori KRAFRRM---FADLRPG---GKLVLEAQNWASYKKKKRLTVNIF------ : Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -------------------------------------------------- Schistosoma_japonicum -------------------------------------------------- Echinococcus_multilocularis -------------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis -------------------------------------------------- Apis_mellifera XXXVFHFNSYTR-------------------------------------- Tribolium_castaneum VIEVLCFVGNN--------------------------------------- Acyrthosiphon_pisum -------------------------------------------------- Lottia_gigantea -------------------------------------------------- Ixodes_scapularis -------------------------------------------------- Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -------------------------------------------------- Ciona_intestinalis -------------------------------------------------- Ciona_savignyi FVAKFVTKTETFW------------------------------------- Trichoplax_adhaerens -------------------------------------------------- Danio_rerio -------------------------------------------------- Tetraodon_nigroviridis ELGRS--------------------------------------------- Pan_troglodytes -------------------------------------------------- Homo_sapiens -------------------------------------------------- Macaca_mulatta -------------------------------------------------- Pongo_pygmaeus PLVEARKGPEVGQGHRP--------------------------------- Canis_familiaris_t2 -------------------------------------------------- Canis_familiaris_t1 -------------------------------------------------- Equus_caballus -------------------------------------------------- Sus_scrofa -------------------------------------------------- Felis_catus -------------------------------------------------- Loxodonta_africana -------------------------------------------------- Mus_musculus -------------------------------------------------- Rattus_norvegicus -------------------------------------------------- Bos_taurus -------------------------------------------------- Monodelphis_domestica -------------------------------------------------- Microcebus_murinus -------------------------------------------------- Echinops_telfari TLSLR-----QKGL------------------------------------ Spermophilus_tridecemlineatus XXXXX-----XXXXXXXXXXX----------------------------- Ochotona_princeps GLTLSGPMAAVHGVQFPGVVH----------------------------- Oryctolagus_cuniculus -------------------------------------------------- Dasypus_novemcinctus -------------------------------------------------- Sorex_araneus -------------------------------------------------- Anolis_carolinensis -------------------------------------------------- Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes XAV----------------------------------------------- Takifugu_rubripes -------------------------------------------------- Capitella_capitata -------------------------------------------------- Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae -------------------------------------------------- Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus -------------------------------------------------- Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii -------------------------------------------------- Reniera_sp -------------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans ------------------------------------XXPEIYNNYKQIEF Drosophila_erecta HXXXEHINGFYNATASRIYHLISVNC--------LSLQPEIYNNYKQIEF Drosophila_melanogaster ---------------------------------------EIYNNYKQIEF Drosophila_yakuba -------------------------------------------------- Drosophila_sechellia -------------------------------------------------- Drosophila_virilis X----XXSHDTFRYV----------------------------------- Drosophila_grimshawi LRLAFYIYNNDNNNI----------------------------------- Drosophila_ananassae I--------DDLRNK----------------------------------- Drosophila_mojavensis QLYTILNCQXXXKEEEPNGMAPTIYYTELPITSNLNLQPEIYNNYKKIEF Drosophila_willistoni NIVELLDLLVTLFLFFLQP--------------------EIYNNYKQIEF Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis X------------------------------------------------- Anopheles_gambiae -------------------------------------------------- Aedes_aegypti -------------------------------------------------- Bombyx_mori -------------------------------------------------- Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -------------------------------------------------- Schistosoma_japonicum -------------------------------------------------- Echinococcus_multilocularis -------------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis -------------------------------------------------- Apis_mellifera -------------------------------------------------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum -------------------------------------------------- Lottia_gigantea -------------------------------------------------- Ixodes_scapularis -------------------------------------------------- Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -------------------------------------------------- Ciona_intestinalis -------------------------------------------------- Ciona_savignyi -------------------------------------------------- Trichoplax_adhaerens -------------------------------------------------- Danio_rerio -------------------------------------------------- Tetraodon_nigroviridis -------------------------------------------------- Pan_troglodytes -------------------------------------------------- Homo_sapiens -------------------------------------------------- Macaca_mulatta -------------------------------------------------- Pongo_pygmaeus -------------------------------------------------- Canis_familiaris_t2 -------------------------------------------------- Canis_familiaris_t1 -------------------------------------------------- Equus_caballus -------------------------------------------------- Sus_scrofa -------------------------------------------------- Felis_catus -------------------------------------------------- Loxodonta_africana -------------------------------------------------- Mus_musculus -------------------------------------------------- Rattus_norvegicus -------------------------------------------------- Bos_taurus -------------------------------------------------- Monodelphis_domestica -------------------------------------------------- Microcebus_murinus -------------------------------------------------- Echinops_telfari -------------------------------------------------- Spermophilus_tridecemlineatus -------------------------------------------------- Ochotona_princeps -------------------------------------------------- Oryctolagus_cuniculus -------------------------------------------------- Dasypus_novemcinctus -------------------------------------------------- Sorex_araneus -------------------------------------------------- Anolis_carolinensis -------------------------------------------------- Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes -------------------------------------------------- Takifugu_rubripes -------------------------------------------------- Capitella_capitata -------------------------------------------------- Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae -------------------------------------------------- Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus -------------------------------------------------- Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii -------------------------------------------------- Reniera_sp -------------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans FPNKFHEYLLSSEVGFSHSYTLGVPRHMNKGFCRPIQXX----------- Drosophila_erecta FPNKFHEYLLSSEVGFSHSYTLGVPRHMNKGFCRPIQVINIFILIHNIQE Drosophila_melanogaster FPNKFHEYLLSSEVGFSHSYTLGVPRHMNKGFCRPIQLY----------- Drosophila_yakuba ---SYHGXX----------------------------------------- Drosophila_sechellia ---SYHXXX----------------------------------------- Drosophila_virilis -------------------------------------------------- Drosophila_grimshawi -------------------------------------------------- Drosophila_ananassae -------------------------------------------------- Drosophila_mojavensis FPNKFHEYLLSPEVGFSHSYTLGVPRHMNKGFCRPIQVRKMIYLKKCEIS Drosophila_willistoni FPNKFHEYLLSSEVGFSHSYTMGVPRHMNKGFCRP--------------- Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis -------------------------------------------------- Anopheles_gambiae -------------------------------------------------- Aedes_aegypti -------------------------------------------------- Bombyx_mori -------------------------------------------------- Schistosoma_mansoni_a -------------------------------------------------- Schistosoma_mansoni_b -------------------------------------------------- Schistosoma_japonicum -------------------------------------------------- Echinococcus_multilocularis -------------------------------------------------- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis -------------------------------------------------- Apis_mellifera -------------------------------------------------- Tribolium_castaneum -------------------------------------------------- Acyrthosiphon_pisum -------------------------------------------------- Lottia_gigantea -------------------------------------------------- Ixodes_scapularis -------------------------------------------------- Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -------------------------------------------------- Ciona_intestinalis -------------------------------------------------- Ciona_savignyi -------------------------------------------------- Trichoplax_adhaerens -------------------------------------------------- Danio_rerio -------------------------------------------------- Tetraodon_nigroviridis -------------------------------------------------- Pan_troglodytes -------------------------------------------------- Homo_sapiens -------------------------------------------------- Macaca_mulatta -------------------------------------------------- Pongo_pygmaeus -------------------------------------------------- Canis_familiaris_t2 -------------------------------------------------- Canis_familiaris_t1 -------------------------------------------------- Equus_caballus -------------------------------------------------- Sus_scrofa -------------------------------------------------- Felis_catus -------------------------------------------------- Loxodonta_africana -------------------------------------------------- Mus_musculus -------------------------------------------------- Rattus_norvegicus -------------------------------------------------- Bos_taurus -------------------------------------------------- Monodelphis_domestica -------------------------------------------------- Microcebus_murinus -------------------------------------------------- Echinops_telfari -------------------------------------------------- Spermophilus_tridecemlineatus -------------------------------------------------X Ochotona_princeps -------------------------------------------------L Oryctolagus_cuniculus -------------------------------------------------- Dasypus_novemcinctus -------------------------------------------------- Sorex_araneus -------------------------------------------------- Anolis_carolinensis -------------------------------------------------- Gasterostreus_aculeatus -------------------------------------------------I Oryzias_latipes -------------------------------------------------H Takifugu_rubripes -------------------------------------------------- Capitella_capitata -------------------------------------------------- Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae -------------------------------------------------- Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus -------------------------------------------------- Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii -------------------------------------------------- Reniera_sp -------------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans -------------------------------------------XLYAKGD Drosophila_erecta LTVVSFSLSAVCKRRLYPESCPLERCLLSSDAIXXXLLFRFPYQLYAKGD Drosophila_melanogaster ----------------------------------------------AKGD Drosophila_yakuba -------------------------------------------XLYAKGD Drosophila_sechellia --------------------------------------------LYAKGD Drosophila_virilis -------------------CSASFSSSPLCAISTYLIFHFLHLQLYAKGD Drosophila_grimshawi -------------------YFLXXXQHFFKLVDYSSISLLLLQQLYAKGD Drosophila_ananassae -------------------KSFINXXX-----------------LYAKGD Drosophila_mojavensis AI----------------DXXXLSNHFEILYESSQTKFPAFSLQLYAKGD Drosophila_willistoni ------------------IQVMQTQSFHSFHRCIINSFLIFLLQLYAKGD Drosophila_pseudoobscura -------------------------------------------------- Drosophila_persimilis -------------------------------------------------- Anopheles_gambiae -------------------------------------------------- Aedes_aegypti -------------------------------------------------- Bombyx_mori -------------------------------------------YFVLTHL Schistosoma_mansoni_a --------------AKHRSIYETLKINPS-----------------NLEP Schistosoma_mansoni_b --------------AKHRSIYETLKINPS-----------------NLEP Schistosoma_japonicum --------LIWXXXAKHRSIYESLKINPS-----------------NLEP Echinococcus_multilocularis -------CFLDXXXIKQQENYKAMTIDPS-----------------NLEP Schizosaccharomyces_pombe ---------------VFNQTPENLKIQPD-----------------AFEH Nasonia_vitripennis -----------ALTEKIYKNYQSIEFFPQ---------------KFTQYL Apis_mellifera ---KNILTLFLSLQERIYKNYQSIEFRPH---------------NFTQYL Tribolium_castaneum ----------FXXXETTFNNYNSIEFFPE---------------KFTEYL Acyrthosiphon_pisum -----------TLTETIWRNYKNILLKPP---------------MFTDYL Lottia_gigantea -----------NLTPNINYNFQNIKLKPE---------------QFRDYL Ixodes_scapularis -----------KLTETTYKHFHDIRLRPE---------------QFNEYL Nematostella_vectensis -----------NLTEKIRANYDSIKFKPE---------------QFLDYL Caenorhabditis_briggsae --------------EELKTNYSKIEFKPD----------------DFEMY Caenorhabditis_brenneri --------------EDLKANYSKIEFKPE----------------DFEMW Caenorhabditis_remanei --------------EELKANYSKIEFKPE----------------DFEMW Caenorhabditis_elegans --------------EELKANYSKIEFKPE----------------DFEMW Caenorhabditis_japonica --------------EELKANYSKIEFKPE----------------DFEMW Ancylostoma_canium --------------ETYMANYAAIEFKPEX-------------XXDFEMY Pristionchus_pacificus -------------XEELKANYRSIEFKPE----------------DFEMY Brugia_malayi -----------DEIKDISDMYKAIEFMPN----------------AFQEY Ciona_intestinalis --------------ERIYKNYNSIELKPA---------------MFPDYL Ciona_savignyi ---KKXXXTIAIKQERIYNHYHSIELLPS---------------MFPDYL Trichoplax_adhaerens --------------ATFRKNFDEIKLMPD---------------QFNDYL Danio_rerio --------------DVTRRNYSSIRLKPD---------------KFSSFL Tetraodon_nigroviridis -----LQISTLLLQDIISKNFHSIRLKPD---------------QFSSYL Pan_troglodytes --------------ETIYKNYYRIQLKPE---------------QFSSYL Homo_sapiens --------------ETIYKNYYRIQLKPE---------------QFSSYL Macaca_mulatta --------------ETIYKNYYRIQLKPE---------------QFSSYL Pongo_pygmaeus ---WPGEAAACXXXETIYKNYYRIQLKPE---------------QFTSYL Canis_familiaris_t2 --------------ETIYKNYYRIQLRPE---------------HFSSYL Canis_familiaris_t1 --------------ETIYKNYYRIQLRPE---------------HFSSYL Equus_caballus --------------ETIYKNYYRIQLKPE---------------QFTSYL Sus_scrofa ------SCPSFXXXETIYKNYYRIQLKPE---------------QFSSYL Felis_catus --------------ETIYKNYFRIQLRPE---------------QFTSYL Loxodonta_africana --------------ETIYKNYYRIQLKPE---------------QFSSYL Mus_musculus --------------ETIYKNYFRIQLKPE---------------QFSSYL Rattus_norvegicus --------------ETIYKNYFRIQLKPE---------------QFSSYL Bos_taurus --------------ERIYKNYFRIQLKPE---------------QFSSYL Monodelphis_domestica --------------ETIYKNYYRIQLKPE---------------QFSSYL Microcebus_murinus --------------ETIYKNYYRIKLKPE---------------QFSSYL Echinops_telfari -------------------------------------------------- Spermophilus_tridecemlineatus RGRRQQAEVLSP--------------------------------AFLPRK Ochotona_princeps GLGEQQAQGIPXXXETTYKNYYRIQLKPE---------------QFSSYL Oryctolagus_cuniculus ---------------------VGIGNNP---------------------- Dasypus_novemcinctus --------------ETIYKNYYRIQLKPE---------------QFSSYL Sorex_araneus ----------------VRRVAGEAGLKCP---------------WVGSRL Anolis_carolinensis -----------AACYLLAVSPVSVGWGKA---------------CSTNNL Gasterostreus_aculeatus CAPTYTLTQSCVFQKATDRNFRSLRLRPE---------------QFTCYL Oryzias_latipes VTSVHVTSVHAVFQDATFRRFRSLRVRPE---------------HFTSIL Takifugu_rubripes ---AHTPTCTV--------------------------------------- Capitella_capitata -------------------------------------------YFFKKLM Daphnia_pulex -------------------------------------------------L Branchiostoma_floridae -------------------------LIRAG-------------YRYSVPV Hydra_magnipapillata ----------------------------------------------GEYI Strongylocentrotus_purpuratus ----------------------------------------------WVQL Trichinella_spiralis ----------------------GLCVKIFD-------------FLQHLFF Saccoglossus_kowalevskii --------------TDACLGCSHLCLRIWQ-------------IVSVNYL Reniera_sp -------------------------LTVRG-------------SSRVTCS Helobdella_robusta --------------VCLFVCLLACLCVVST-------------CLFVYVL Drosophila_simulans YTPNHVRWSDAYYPQTPYEAYRGIYA-----TLPV---HRMGGG--GSSA Drosophila_erecta YTPNHVRWSDAYYPQTPYEAYRGIYA-----TLPV---HRMGGG--GSSA Drosophila_melanogaster YTPNHVRWSDAYYPQTPYEAYRGIYA-----TLPV---HRMGGG--GSSA Drosophila_yakuba YTPNHVRWSDAYYPQTPYEAYRGIYA-----TMPV---HRMGGG--GSSA Drosophila_sechellia YTPNHVRWSDAYYPQTPYEAYRGIYA-----TLPV---HRMGGG--GSSA Drosophila_virilis YTPNHVRWSDAYYPQTPYEAYRGIYA-----TLPA---HRTGGG--SSSA Drosophila_grimshawi YTPNHVRWSDAYYPQTPYEAYRGIYA-----TLPAGVGHRTGGGGSSSSA Drosophila_ananassae YTPNHVRWSDAYYPQTPYEAYRGIYA-----TLPA---NRMGGG--GSSV Drosophila_mojavensis YTPNHVRWSDAYYPQTPYEAYRGIYA-----TLPV---HRAGGG--GSSA Drosophila_willistoni YTPNHVRWSDAYYPQTPYEAYRGIYA-----TLPVHGRMGGGGGSSGGAS Drosophila_pseudoobscura --------DQPWSLHT-----RAIRY-----SLRI--------------- Drosophila_persimilis ------XXDHPWSLHT-----RAIRY-----SLRN--------------- Anopheles_gambiae ---------------TIFENYQKIEFFPKYF---------------HDYL Aedes_aegypti -------------------------------------------------- Bombyx_mori XXXKEIEKRLFCLQPTIYENFNSIELFPIKF---------------RDYL Schistosoma_mansoni_a LLVDLGFSYFDTIKDPRPNEPFRR-------------------------- Schistosoma_mansoni_b LLVDLGFSYFDTIKDPRPNEPFRR-------------------------- Schistosoma_japonicum LLVDLGFSYFDTIKAPRPNEPFRR-------------------------- Echinococcus_multilocularis ILLDIGFSYFDKIKVPRPNESFQR-------------------------- Schizosaccharomyces_pombe LLNQAGLVLEYSIEPQVNNSEYKN-------------------------- Nasonia_vitripennis LSAEVGFRKCEVVSVPPHPSR----------------------------- Apis_mellifera LSSEVGFSKCEVLSIPPHPAK----------------------------- Tribolium_castaneum LSSVVGFAKSEILGFPYNHSK----------------------------- Acyrthosiphon_pisum LN-EVGFANCETLTMPHNPSK----------------------------- Lottia_gigantea LA-EVGFHKCEVIDVVXHKAK----------------------------- Ixodes_scapularis LSPEVGFASCELIDTPSHASK----------------------------- Nematostella_vectensis LSDEVGFAAFEVLNPQDQTQT----------------------------- Caenorhabditis_briggsae LIETIGFESVDKLGVSGAKSK----------------------------- Caenorhabditis_brenneri LIETVGFESVEKLGVSGAKSK----------------------------- Caenorhabditis_remanei LIETVGYESVEKLGVATAKSK----------------------------- Caenorhabditis_elegans LIETVGFESVEKLGVVGAKSK----------------------------- Caenorhabditis_japonica LIETVGFESVEKMGVTGAKSK----------------------------- Ancylostoma_canium LIETDALESVEHLGAASAKTK----------------------------- Pristionchus_pacificus LIEECGFESVQHLAVTGAKAKXX--------------------------- Brugia_malayi LIVDIGFDICQHIDPPKAHTK----------------------------- Ciona_intestinalis I-KVVGFESVEYLTLTTQNRS----------------------------- Ciona_savignyi I-NVVGFESVEYLTSTVPNTP----------------------------- Trichoplax_adhaerens LSEEIGFSSCQTLPIPN-DAV----------------------------- Danio_rerio MA-EVGFSSYELIGTPRASPKGLQR------------------------- Tetraodon_nigroviridis TT-EVGFTSFEYLGAPKCPNKGFQR------------------------- Pan_troglodytes TSPDVGFSSYELVATPHNTSKG---------------------------- Homo_sapiens TSPDVGFSSYELVATPHNTSKG---------------------------- Macaca_mulatta TSPDVGFSSYELVATPHNTSKG---------------------------- Pongo_pygmaeus TSPDVGFSSYELVATPHNTSKGKAGLFCQGGWSWLKECR----------P Canis_familiaris_t2 TSPEVGFSSYELVATPHNTSRG---------------------------- Canis_familiaris_t1 TSPEVGFSSYELVATPHNTSRG---------------------------- Equus_caballus TSPEVGFSSYELVATPHNTSKG---------------------------- Sus_scrofa TSPEVGFSSYELVATPHNTSKGKAGLFCWGWKGGLSWCRVDPVESLKVLP Felis_catus TSPEVGFSSYELVATPHNTSRG---------------------------- Loxodonta_africana TSPEVGFSSYELVATPHNTSKGK--------------------------- Mus_musculus TSPEVGFSSYELVATPNNTSRG---------------------------- Rattus_norvegicus TSPEVGFSSYELVATPSNTSRGKNGWEGLVLATRVQALWRTPRSYPP--A Bos_taurus TSPEVGFSSYELVATPNNTSRG---------------------------- Monodelphis_domestica TSPEVGFSSYELVATPHNSSKG---------------------------- Microcebus_murinus MSPEVGFSSYELVATPHNTSKGKAGLFCWGRQSWLRG------------- Echinops_telfari -------------------------------------------------- Spermophilus_tridecemlineatus QSIRTTFES----------------------------------------- Ochotona_princeps TSPEVGFSSYELVATPYHTSKGKAGSSGGGSCRSRPCQVYSNCHLPSG-- Oryctolagus_cuniculus ------FSEVRKAAKHQKSSPGGP-------RGQGRKQQAEG-------- Dasypus_novemcinctus TSPEVGFSSYELVATPHNTSRGKAGLVWGRGGGVGWCLLTEG-------- Sorex_araneus KRPSTPLPRKPPTRTTSESS------------------------------ Anolis_carolinensis WPQSICTIDSGKLENGTDKAKGWEENWQTGWKAIAVQKESE--------- Gasterostreus_aculeatus TDSVGFTSYRLITHSGTHTLSTHKH------------------------- Oryzias_latipes TDSVGFSSYRLLTHTGEGEDGALRGRAGH--------------------- Takifugu_rubripes -------------------------------------------------- Capitella_capitata KISFFPFLLK---------------------------------------- Daphnia_pulex NISFFLFP------------------------------------------ Branchiostoma_floridae QNRFFLLDRSRKTGPEKNQWT----------------------------- Hydra_magnipapillata D------------------------------------------------- Strongylocentrotus_purpuratus ETGLDSFSN----------------------------------------- Trichinella_spiralis MINFFLLVLARRIHHSARS------------------------------- Saccoglossus_kowalevskii CINWNLLSKKYAYHSRAACHITILILS----------------------- Reniera_sp MKLQCCLGDKW--------------------------------------- Helobdella_robusta VCLFICLCSCQFVCTXXXNWYACG-------------------------- Drosophila_simulans GGSNSGHA---QMLHLSSSSRSQNYDTPHYAGSASGSASCRQTPMYQPTY Drosophila_erecta GGSNSGHA---QMLHLSSSSRSQNYDTPHYAGSASGSASCRQTPMYQPTY Drosophila_melanogaster GGSNSGHA---QMLHLSSSSRSQNYDTPHYAGSASGSASCRQTPMYQPTY Drosophila_yakuba GGSNSGHA---QMLHLSSSSRSQNYDTPHYAGSASGSASCRQTPMYQPTY Drosophila_sechellia GGSNSGHA---QMLHLSSSSRSQNYDTPHYAGSASGSASCRQTPMYQPTY Drosophila_virilis GGSHGGHA---QLHLLSSSTRSQNYDTPHYAGSASGSASCRQTPMYQHTY Drosophila_grimshawi GGSQSGHAPHHLHHLLGSSTRSQTYDTPQYAGSASGSASCRQTPMYQHTY Drosophila_ananassae GGSHSGHA---QLLHMSSSSRSQNYDTPHYAGSASGSASCRQTPMYQPTY Drosophila_mojavensis GGSHGGHA---QLHLLSSSTRSQNYDTPQYAGSASGSASCRQTPMYQHTY Drosophila_willistoni SSHHGGHG-HHQLMHLSSSTRSQNYDTPHYAGSASGSASCRQTPMYQPTY Drosophila_pseudoobscura -AENFGFS-----LSLTLHLIRKLIRSLLQAEIYNNYKQIELFPNKFHEY Drosophila_persimilis -AENFGFS-----FSLTLHLIRKLIRSLLQAEIYNNYKQIELFPNKFHEY Anopheles_gambiae LSPEVGFS----HSFPLGIPRHLSKGFRRPIQLYIKGDFTPSQAKWSDTY Aedes_aegypti -DPRKGNS----EFYPISFPLSLGN------------------------- Bombyx_mori LSPEVGFS----KCCILGVPQHASKGFRRPIQLYIKGDFTPSKARWSDAY Schistosoma_mansoni_a --------------KIILCSKSYGATPASIRNDFRSEVHNWQSFNSPHSP Schistosoma_mansoni_b --------------KIILCSKSYGATPASIRNDFRSEVHNWQSFNSPHSP Schistosoma_japonicum --------------KIILCSKSYGATPASIRNDFRSEVHNWQSFNSPHSP Echinococcus_multilocularis --------------CIMLCSKSYGATPSSIRNDCREAAHLWRGSPILSDT Schizosaccharomyces_pombe --------------FAKRTMYIYKKKGIGIIKLLTST------------- Nasonia_vitripennis --------------GFQRPIYLYTKADDVTSPAAIATTS-------ETAA Apis_mellifera --------------GFQRPIHLFTKADLSQDDLRKSMLNRQERRDEERRK Tribolium_castaneum --------------GFRRPIQIFTKSTMFPSERIEATPN--------NSI Acyrthosiphon_pisum --------------GFQRPLKLFRKPNILVNR------------------ Lottia_gigantea --------------GFRRPISGYTKSESSES------------------- Ixodes_scapularis --------------GFQRPIYLFTKAESAEEQCAAAKSE---------CG Nematostella_vectensis --------------GFKRPLYLFTKAVQPVN------------------- Caenorhabditis_briggsae --------------GFERPIDVYLKPV-RPKTDAIPLGYI---------- Caenorhabditis_brenneri --------------GFERPIDVYLKPL-YPKTDAIPLGYI---------- Caenorhabditis_remanei --------------GFERPIDVYLKPV-RPKTGAIPLGYI---------- Caenorhabditis_elegans --------------GFERPIDVYLKPL-HPKTDAIPLGYI---------- Caenorhabditis_japonica --------------GFERPIDVYLKPL-RPKTDAIPLGYK---------- Ancylostoma_canium --------------GFERPIDVYLNTP-QFFLGTRGQD------------ Pristionchus_pacificus -------------XGFDRPIDVYVKKP-PAFMRRKETKKTDKEKKEKDEI Brugia_malayi --------------GFERPIQVYCKRVSHSFTKASCYDHDSLPKTCAADS Ciona_intestinalis -------------EGFKRPIQLYRKPE----------------------- Ciona_savignyi -------------VG----KWLF--------------------------- Trichoplax_adhaerens -------------KGM---------------------------------- Danio_rerio ------------------SVYLFHKSPASSRK------------------ Tetraodon_nigroviridis ------------------PIFLFHK------------------------- Pan_troglodytes -------FQR--------PVYLFHKARS---------PSH---------- Homo_sapiens -------FQR--------PVYLFHKARS---------PSH---------- Macaca_mulatta -------FQR--------PVYLFHKARS---------PSH---------- Pongo_pygmaeus PWGFLRCCQP--------LLIILSPLRL---------PASCVPVPQGSIP Canis_familiaris_t2 -------FQR--------SVYLFHKARS---------PSH---------- Canis_familiaris_t1 -------FQR--------SVYLFHKARS---------PSH---------- Equus_caballus -------FQR--------PVYLFHKARS---------PSH---------- Sus_scrofa TPPDGTLFLRLPASCVPVPQGLFPQPLSGLLNREYEEAAHCS-------- Felis_catus ------------------KVG----------------------------- Loxodonta_africana -----------------ATLFCWGTGRE---------GAIG--------- Mus_musculus -------FQR--------PVYLFHKARS---------PSH---------- Rattus_norvegicus SVFFPAGFQR--------PVYLFHKARS---------PSH---------- Bos_taurus -------FQR--------PVYLFHKAQS---------PSH---------- Monodelphis_domestica -------FQR--------PVYLFHKANS---------PSH---------- Microcebus_murinus -------HRDSVGSREVLPALLIAHSPLR-------LPASCVPVPQGPFP Echinops_telfari -------------------------------------------------- Spermophilus_tridecemlineatus -------------------------------------------------- Ochotona_princeps -------FQR--------PVYLFHKAQA---------PSH---------- Oryctolagus_cuniculus ------VPSLCFWETTYTNYYRIQGKPKQ-------FTS----------- Dasypus_novemcinctus ------GTDPVGSLRSPGQPLLIVHSPLR-------LPSSCVPVPQGPLP Sorex_araneus -------------------------------------------------- Anolis_carolinensis -------FSRHTKVALVGLMMVVMIITQQHYVTLFLFLG----------- Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes -------------------------------------------------- Takifugu_rubripes -------------------------------------------------- Capitella_capitata -------------------------------------------------- Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae -------------------------------------------------- Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus -------------------------------------------------- Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii ---------LIRPGPLNGSFGVFSPRLDEV-------------------- Reniera_sp -------------------------------------------------- Helobdella_robusta ----------------YAAIDVSRCLAFCKLIYTHYIIIKLLSSSMLSYV Drosophila_simulans NPLETDSYQPSYDMEYLNHMYVFASPLYQTVWSPPASLRKSSSHTPVFGS Drosophila_erecta NPLETDSYQPSYDMEYLNHMYVFASPLYQTVWSPPASLRKSSSHTPVFGS Drosophila_melanogaster NPLETDSYQPSYDMEYLNHMYVFASPLYQTVWSPPASLRKSSSHTPVFGS Drosophila_yakuba NPLETDSYQPSYDMEYLNHMYVFASPLYQTVWSPPASLRKSSSHTPVFGS Drosophila_sechellia NPLETDSYQPSYDMEYLNHMYVFASPLYQTVWSPPASLRKSSSHTPV--- Drosophila_virilis NPLETDSYQPSYDMEYLNHMYVFASPLYQTVWSPPASLRKSSSHTPVFGS Drosophila_grimshawi NPLETDSYQPSYDMEYLNHMYVFASPLYQTVWSPPASLRRSSSHTPVFGS Drosophila_ananassae NPLETDSYQPSYDMEYLNHMYVFASPLYQTVWSPPASLRKSSSHTPVFGS Drosophila_mojavensis NPLETDSYQPSYDMEYLNHMYVFASPLYQTVWSPPASLRKSSSHTPVFGS Drosophila_willistoni NPLETDSYQPSYDMEYLNHMYVFASPLYQTVWSPPASLRKSSSHTPVFGS Drosophila_pseudoobscura LLSSEVGFSHSYTLGVPRHMNKGFCRPIQVSAATWQVPCDSHLTNPILLS Drosophila_persimilis LLSSEVGFSHSYTLGVPRHMNKGFCRPIQVSAATWQVPCDSHLINRILLS Anopheles_gambiae HPGTPYENHRGIYTDIVTASQSAAGCIWGAMTPYAPSYSYRQPPTPSHGG Aedes_aegypti -------------------------------------------------- Bombyx_mori VPSSHHRPEAEQPRRTVYAPVEP--------------------------- Schistosoma_mansoni_a HG--REPPPVCYLPQTPVYN----------VGTPFTTGSSPMSRHI--CA Schistosoma_mansoni_b HG--REPPPVCYLPQTPVYN----------VGTPFTTGSSPMSRHI--CA Schistosoma_japonicum HN--REPPPVCYLPQTPVYN----------LGTPFTTGNSPTYRHL--CV Echinococcus_multilocularis FGPPAGPPPVRYCPQTPNYSSIVSPAVLDAYPTFDSSGATPNTIHLGDVL Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis SASTTTPSATNDSAMDVSIEACSHRLGGESFSQYENLENVYAPSVTPCYD Apis_mellifera LKEYERKLFKKEDAKEGNMSEISQQSN-ESMSQYDQLENVYAPSATPCYD Tribolium_castaneum TPNNDDPLYQKLLKTEKYESQTQPLVEKSEHIYYTNILNRYCGNSEENFE Acyrthosiphon_pisum ---------NKPKSTIVQPNETQKL------------------------- Lottia_gigantea ----------------ANEPNKTPRFN----------------------- Ixodes_scapularis SPTKAGCEKEGERDSGSEKPEREPPTEKRK-------------------- Nematostella_vectensis -------------------PTSK--------------------------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus KEEEVVTTEKESKISESEVKPDESVLE----------------------- Brugia_malayi FSLCNVTSEVVTKTSIAMESHVG--------------------------- Ciona_intestinalis -------------------------------------------------- Ciona_savignyi -------------------------------------------------- Trichoplax_adhaerens -------------------------------------------------- Danio_rerio -------------------------------------------------- Tetraodon_nigroviridis -------------------------------------------------- Pan_troglodytes -------------------------------------------------- Homo_sapiens -------------------------------------------------- Macaca_mulatta -------------------------------------------------- Pongo_pygmaeus QPLSGPLNRKCDEAVLSAHKDLGEEESVPRSFLSDSKNSFLSWICKESFS Canis_familiaris_t2 -------------------------------------------------- Canis_familiaris_t1 -------------------------------------------------- Equus_caballus -------------------------------------------------- Sus_scrofa -------------------------------------------------- Felis_catus -------------------------------------------------- Loxodonta_africana -------------------------------------------------- Mus_musculus -------------------------------------------------- Rattus_norvegicus -------------------------------------------------- Bos_taurus -------------------------------------------------- Monodelphis_domestica -------------------------------------------------- Microcebus_murinus QPLSGPLNRKCEEAALTAPKDLGEEESILRSFLSDSKKFPFLDLQRKLFL Echinops_telfari -------------------------------------------------- Spermophilus_tridecemlineatus -------------------------------------------------- Ochotona_princeps -------------------------------------------------- Oryctolagus_cuniculus -------------------------------------------------- Dasypus_novemcinctus -------------------------------------------------- Sorex_araneus -------------------------------------------------- Anolis_carolinensis -------------------------------------------------- Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes -------------------------------------------------- Takifugu_rubripes -------------------------------------------------- Capitella_capitata -------------------------------------------------- Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae -------------------------------------------------- Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus -------------------------------------------------- Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii -------------------------------------------------- Reniera_sp -------------------------------------------------- Helobdella_robusta IIKRXXXVQPKMHQNSPXFPP----------------------------- Drosophila_simulans V------------------------------------------------- Drosophila_erecta VRDAELDGDG-SGGGGSGGGSYHRHVYPPNDDTCSPNANACNAFNSIRDA Drosophila_melanogaster VRDAELDGDG-SGGGGSGGGSYHRHVYPPNDDTCSPNANACNAFNSIRDA Drosophila_yakuba VRDAELDXXX-XXXXXXXXXSYHRHVYPPNDDTCSPNANACNAFNSIRDA Drosophila_sechellia -------------------------------------------------- Drosophila_virilis VRDAELDGDGSIGGGGSGGGSYHRHVYPPNDDTCSPNANACNAFNSIRDA Drosophila_grimshawi VREAELDGDGSIGGGGSGGGSYHRHVYPPNDDTCSPNANACNAFNSIRDA Drosophila_ananassae VRDAELDGDGSIGGGGSGGGSYHRHVYPPNDDTCSPNANACNAFNSIRDA Drosophila_mojavensis VRDAELDGDVSISGGGSGGGSYHRHVYPPNDDTCSPNANACNAFNSIRDA Drosophila_willistoni VRDAELDGDGSIGGGGSGGGSYHRHVYPPNDDTCSPNANACNAFNSIRDA Drosophila_pseudoobscura LC------------------------------SCTPRATTHRTMS----- Drosophila_persimilis LR------------------------------SCTPRATTHRTMS----- Anopheles_gambiae GSGGGSGGFASTSPYYNPRQTDSYLPSYDIANTHRPGSYCFASPIYSTTW Aedes_aegypti ------------------LGSKACLLEMGAKDHKFPNNVIFKTVSCNVKL Bombyx_mori -----------------AYRPSDDAPSCGAATPYSPNLDCCTDDSPFYNP Schistosoma_mansoni_a SSTVLSPTVLPSVSPLIAVVDPVSTPT------------CEPDSTSNC-- Schistosoma_mansoni_b SSTVLSPTVLPSVSPLIAVVDPVSTPT------------CEPDSTSNC-- Schistosoma_japonicum SSTVLSPSVLPNVSPLVTTVDSMPTPS------------CEPDSTSY--- Echinococcus_multilocularis QSAIISSTVPFTNSDLTPGEATPPHPLDSEVGVANYSNISAPDSTSQN-- Schizosaccharomyces_pombe -------------------------------------------------- Nasonia_vitripennis TPIHNVDSNPPDPEKMCYLDVKIEHDQSESNHVTENGNKTSPTAEEDQQQ Apis_mellifera TIGHNNDNQPSDASKMCYVDV----------------------------- Tribolium_castaneum VNKQIEDDLNKEQ-----LDEK---SQSEMQDVSGDNT------------ Acyrthosiphon_pisum -------------------------------------------------- Lottia_gigantea -------------------------------------------------- Ixodes_scapularis -------------------------------------------------- Nematostella_vectensis -------------------------------------------------- Caenorhabditis_briggsae -------------------------------------------------- Caenorhabditis_brenneri -------------------------------------------------- Caenorhabditis_remanei -------------------------------------------------- Caenorhabditis_elegans -------------------------------------------------- Caenorhabditis_japonica -------------------------------------------------- Ancylostoma_canium -------------------------------------------------- Pristionchus_pacificus -------------------------------------------------- Brugia_malayi -------------------------------------------------- Ciona_intestinalis -------------------------------------------------- Ciona_savignyi -------------------------------------------------- Trichoplax_adhaerens -------------------------------------------------- Danio_rerio -------------------------------------------------- Tetraodon_nigroviridis -------------------------------------------------- Pan_troglodytes -------------------------------------------------- Homo_sapiens -------------------------------------------------- Macaca_mulatta -------------------------------------------------- Pongo_pygmaeus SVAASASSLRLWHLHSKAGCAGVTIIFLSPSLPGWMAWTVC--------- Canis_familiaris_t2 -------------------------------------------------- Canis_familiaris_t1 -------------------------------------------------- Equus_caballus -------------------------------------------------- Sus_scrofa -------------------------------------------------- Felis_catus -------------------------------------------------- Loxodonta_africana -------------------------------------------------- Mus_musculus -------------------------------------------------- Rattus_norvegicus -------------------------------------------------- Bos_taurus -------------------------------------------------- Monodelphis_domestica -------------------------------------------------- Microcebus_murinus CCCPCLPYTSGT-------------------------------------- Echinops_telfari -------------------------------------------------- Spermophilus_tridecemlineatus -------------------------------------------------- Ochotona_princeps -------------------------------------------------- Oryctolagus_cuniculus -------------------------------------------------- Dasypus_novemcinctus -------------------------------------------------- Sorex_araneus -------------------------------------------------- Anolis_carolinensis -------------------------------------------------- Gasterostreus_aculeatus -------------------------------------------------- Oryzias_latipes -------------------------------------------------- Takifugu_rubripes -------------------------------------------------- Capitella_capitata -------------------------------------------------- Daphnia_pulex -------------------------------------------------- Branchiostoma_floridae -------------------------------------------------- Hydra_magnipapillata -------------------------------------------------- Strongylocentrotus_purpuratus -------------------------------------------------- Trichinella_spiralis -------------------------------------------------- Saccoglossus_kowalevskii -------------------------------------------------- Reniera_sp -------------------------------------------------- Helobdella_robusta -------------------------------------------------- Drosophila_simulans -------------------------------------------------- Drosophila_erecta DTDDSNQLPGGSRRHVYATNCGESSSSPQVNHHEAVGEF-VDALMDDEQK Drosophila_melanogaster DTDDSNQLPGGSRRHVYATNCGESSSSPQVNHHDAVGEF-VDGLMDDEQK Drosophila_yakuba DTDDSNQLPGGSRRHVYATNCGESSSSPQVNHHEAVGEF-VDALMDDEQK Drosophila_sechellia -------------------------------------------------- Drosophila_virilis DTEDSNQLPGGSRRHVYATNCGESSSSPQVNHHEASAEF-VDALMDDEQK Drosophila_grimshawi DTDDSNQLPGGSRRHVYATNCGESSSSPQVNHHEASSDADVDALMDDEQK Drosophila_ananassae DTDDSNQLPGGSRRHVYATNCGESSSSPQVNHHEAAGEF-VDALMDDEQK Drosophila_mojavensis DTDDSNQLPGGSRRHVYATNCGESSSSPQVNHHEASVEF-ADALMDDEQK Drosophila_willistoni DTDDSNQLPSSSRRHVYATNCGESSSSPQVNHHEATGEY-VDALMDDEQK Drosophila_pseudoobscura ----DGATPTIRRRRTRPIAGSTPPCRPIG-------------------- Drosophila_persimilis ----DGAMPTIRRRRTRPIAGSTPPCRPIG-------------------- Anopheles_gambiae SPPSDMLATSGGGGGSYRRSASNTPNSASIRSVDNDDHYYVSTASGGSSQ Aedes_aegypti NR------------------------------------------------ Bombyx_mori RSDSYAPSYQPPRPTVYATLPSPLGSASPAQSPAASPAPHASPAPDPLTA Schistosoma_mansoni_a -------------------------- Schistosoma_mansoni_b -------------------------- Schistosoma_japonicum -------------------------- Echinococcus_multilocularis -------------------------- Schizosaccharomyces_pombe -------------------------- Nasonia_vitripennis RPDGGSSELTEQQEDKT--------- Apis_mellifera -------------------------- Tribolium_castaneum -------------------------- Acyrthosiphon_pisum -------------------------- Lottia_gigantea -------------------------- Ixodes_scapularis -------------------------- Nematostella_vectensis -------------------------- Caenorhabditis_briggsae -------------------------- Caenorhabditis_brenneri -------------------------- Caenorhabditis_remanei -------------------------- Caenorhabditis_elegans -------------------------- Caenorhabditis_japonica -------------------------- Ancylostoma_canium -------------------------- Pristionchus_pacificus -------------------------- Brugia_malayi -------------------------- Ciona_intestinalis -------------------------- Ciona_savignyi -------------------------- Trichoplax_adhaerens -------------------------- Danio_rerio -------------------------- Tetraodon_nigroviridis -------------------------- Pan_troglodytes -------------------------- Homo_sapiens -------------------------- Macaca_mulatta -------------------------- Pongo_pygmaeus -------------------------- Canis_familiaris_t2 -------------------------- Canis_familiaris_t1 -------------------------- Equus_caballus -------------------------- Sus_scrofa -------------------------- Felis_catus -------------------------- Loxodonta_africana -------------------------- Mus_musculus -------------------------- Rattus_norvegicus -------------------------- Bos_taurus -------------------------- Monodelphis_domestica -------------------------- Microcebus_murinus -------------------------- Echinops_telfari -------------------------- Spermophilus_tridecemlineatus -------------------------- Ochotona_princeps -------------------------- Oryctolagus_cuniculus -------------------------- Dasypus_novemcinctus -------------------------- Sorex_araneus -------------------------- Anolis_carolinensis -------------------------- Gasterostreus_aculeatus -------------------------- Oryzias_latipes -------------------------- Takifugu_rubripes -------------------------- Capitella_capitata -------------------------- Daphnia_pulex -------------------------- Branchiostoma_floridae -------------------------- Hydra_magnipapillata -------------------------- Strongylocentrotus_purpuratus -------------------------- Trichinella_spiralis -------------------------- Saccoglossus_kowalevskii -------------------------- Reniera_sp -------------------------- Helobdella_robusta -------------------------- Drosophila_simulans -------------------------- Drosophila_erecta SSTGGG--------TGGAAYCDLSDA Drosophila_melanogaster SSTGGG--------TGGAAYCDLSDA Drosophila_yakuba SSTGGG--------TSGSAYCDLSDA Drosophila_sechellia -------------------------- Drosophila_virilis TLAAG----------SGAAYCDLSDA Drosophila_grimshawi TLAAG----------SGATYCDLSDA Drosophila_ananassae SSTGGG---------SGGAYCDLPDA Drosophila_mojavensis TLAVGTSGGGG--VGGGTAYCDLSDA Drosophila_willistoni TLAAGSSSGGGGVAGGAGVDCDLSDA Drosophila_pseudoobscura -------------------------- Drosophila_persimilis -------------------------- Anopheles_gambiae RRHHVYPP------------------ Aedes_aegypti -------------------------- Bombyx_mori RGFPEPRPHDD---------------