CLUSTAL W (1.83) multiple sequence alignment Tn_gsh1_Ib MPRSFLVDSLILRETSDKGND-------------NNPPLFPYAVHSPHHS Tr_gsh-1_Ib MPRSFLVDSLILRETSDKGNE-------------NNPPLFPYAVHSSHHP Ol_gsh-1_Ib_X MPRSFLVDSLILREANEKGSE-------------NNPPLFPYAMHSPHHA Dr_gsh-1_Ib MPRSFLVDSLILRENSEKGTE-------------NSPPLFPYAVHPSHPL Hs_gsh1 MPRSFLVDSLVLREAGEKKAPEG-----------SPPPLFPYAVPPPHAL Mm_gsh1 MPRSFLVDSLVLREASDKKAPEG-----------SPPPLFPYAVPPPHAL Xt_gsx-1 MPRSFLVDSLILRETNEKKVE-------------SSPPLFPYAVHPTHPL Tr_gsh-2_IIIa MSRSFYVDSLIIKDVV-RPA---------QAEHPGKDFLIPISMHSPSVM Tn_gsh-Chr1rnd MSRSFYVDSLIIKDVG-RPL---------QAEHPGKDFLIPISMHSPSVM Ol_gsh-2_IIIa_X MSRSFYVDSLIIKDTV-RPG---------PADHPGQDFLIPISMHSPSVM Dr_gsh-2_IIIa MSRSFYVDSLIIKDPA-RPT---------LSEHTAQDFLIPIGMHSPGVM Hs_gsh2 MSRSFYVDSLIIKDTS-RPAPSL------PEPHPGPDFFIPLGMPPPLVM Mm_gsh2 MSRSFYVDSLIIKDSS-RPAPSL------PESHPGPDFFIPLGMPSPLVM Xt_gsh2 MSRSFYVDSLIIKDSSSRPIPALPDLSHHHHHHHGQDFLLPISMPSPTVM AmphiGsx MSRSFLVDSLIQRDMSPKST---------------QATACVGHRGPLSPL *.*** ****: :: : . Tn_gsh1_Ib HGMPT-SCHSRKAGLLCFCPLCMAASQLHPS------------------- Tr_gsh-1_Ib HGMPT-SCHSRKAGLLCFCPLCMTASQLHPS------------------- Ol_gsh-1_Ib_X HGLPG-SCHSRKAGMLCFCPLCMAASQLHPS------------------- Dr_gsh-1_Ib HSLSAGSCHSRKAGLLCFCPLCVTS-QLHPS------------------- Hs_gsh1 HGLSPGACHARKAGLLCVCPLCVTASQLHGPP------------------ Mm_gsh1 HGLSPGACHARKAGLLCVCPLCVTASQLHGPP------------------ Xt_gsx-1 HGLPAGSCHSRKSGLLCVCPMCVTASHLHPP------------------- Tr_gsh-2_IIIa T-VTAPVCPSRKSGTFCVCPLCVTS-HIHSSR------------------ Tn_gsh-Chr1rnd T-VTAPVCPSRKNGTFCVCPLCVTS-HIHSSR------------------ Ol_gsh-2_IIIa_X S-VTAPVCPSRKTGTFCVCPLCVTS-HIHAPC------------------ Dr_gsh-2_IIIa S-VTAPICPSRKTGTFCVCPLCVSS-HIHSPR------------------ Hs_gsh2 S-VSGPGCPSRKSGAFCVCPLCVTS-HLHSSRGSVGAGSGGAGAGVTGAG Mm_gsh2 S-VSGPGCPSRKSGAFCVCPLCVTS-HLHSSRPPAGAGGGATGTAGAAVA Xt_gsh2 S-VHAPVCPSRKSGSFCVCPICVAS-HLHSSR------------------ AmphiGsx TAAQLGLYPRKDAAIFGQCLLCVQATSSPPTTG----------------- :. . : * :*: : . Tn_gsh1_Ib -------PPTLPLLKAS--FPPFATQYCHSALSRQHA------------- Tr_gsh-1_Ib -------PPTLPLLKAS--FPPFTTQYCHSALSRQHT------------- Ol_gsh-1_Ib_X -------PPTLPLLKAS--FPPFSSQYCHSALSRQHA------------- Dr_gsh-1_Ib -------PPALPLIKAS--FPAFGTQYCHSALSRQHS------------- Hs_gsh1 ------GPPALPLLKAS--FPPFGSQYCHAPLGRQHSA------------ Mm_gsh1 ------GPPALPLLKAS--FPPFGSQYCHAPLGRQHS------------- Xt_gsx-1 -------PPGIPLLKAS--FSSFGTQYCPAGLGRQHS------------- Tr_gsh-2_IIIa --------SGIPMLKSQ--FPAAEVQYCQRIAHQQ--------------- Tn_gsh-Chr1rnd --------SGIPMLKSQ--FPAAEVQYCQRIAHQQ--------------- Ol_gsh-2_IIIa_X --------SGIPMLKSQ--FPGAEAQYCQRLAQQQ--------------- Dr_gsh-2_IIIa --------GGIPLLKGQG-FTAGDAAFCQRMAHQQ--------------- Hs_gsh2 GSGVAGAAGALPLLKGQFSSAPGDAQFCPRVNHAHHHHHPPQHHHHHHQP Mm_gsh2 GGGVAGGTGALPLLKSQFSPAPGDAQFCPRVSHAHHHHHPPQHHHHHHQP Xt_gsh2 --------NSIPLLKGH--FPNGEAQYCQRVSQQP--------------- AmphiGsx -------HSHFGVPRTS--VPTTVPSFVSTLPTTMP-------------- : : : . : Tn_gsh1_Ib ------------------ASNGVN-----LSHAPGIYQAAYSVPDPRQFH Tr_gsh-1_Ib ------------------SSNGVS-----LSHAPGIYQAAYSVPDPRQFH Ol_gsh-1_Ib_X ------------------SSNSIS-----LSQGAGIYQAAYSVPDPRQFH Dr_gsh-1_Ib ------------------TSSGVN-----LNSGSGLYQAAYPVPDPRQFH Hs_gsh1 ------------------VSPGVAHGPAAAAAAAALYQTSYPLPDPRQFH Mm_gsh1 ------------------VSPGVAHGPAAAAAAAALYQTSYPLPDPRQFH Xt_gsx-1 ------------------ASTGIN-----VSHGPALYQAAYPLPDPRQFH Tr_gsh-2_IIIa -------------------SPALAHP----GQTPVCTPT-FSVTDPRRYH Tn_gsh-Chr1rnd -------------------SPALAHP----GHTPVCTPT-FSVTDPRRYH Ol_gsh-2_IIIa_X -------------------PPALAHP----GHAPVCTPT-FSVRDPRRYH Dr_gsh-2_IIIa -------------------SPALAHPG--HGHAPVCTPTSFSVTDPRRYH Hs_gsh2 QQPG-SAAAAAAAAAAAAAAAALGHP---QHHAPVCTATTYNVADPRRFH Mm_gsh2 QQPGSAAAAAAAAAAAAAAAAALGHP---QHHAPVCAATTYNMSDPRRFH Xt_gsh2 -------------------SPAMVHP----AHSPVCSPT-YNVTDPRRFH AmphiGsx -------------------TTALQ------GISYAISRHHTPATSAFLSL . .: .. Tn_gsh1_Ib CISLENG-NSKLQSSKRMRTAFTSTQLLELEREFTSNMYLSRLRRIEIAT Tr_gsh-1_Ib CISIENS-NSKLQSSKRMRTAFTSTQLLELEREFTSNMYLSRLRRIEIAT Ol_gsh-1_Ib_X CISLENS-NGKLQSSKRMRTAFTSTQLLELEREFTSNMYLSRLRRIEIAT Dr_gsh-1_Ib CISIENS-SSQLQSSKRMRTAFTSTQLLELEREFTSNMYLSRLRRIEIAT Hs_gsh1 CISVDSS-SNQLPSSKRMRTAFTSTQLLELEREFASNMYLSRLRRIEIAT Mm_gsh1 CISVDSS-SNQLPSSKRMRTAFTSTQLLELEREFASNMYLSRLRRIEIAT Xt_gsx-1 CISVDSS-PSQLSSSKRMRTAFTSTQLLELEREFASNMYLSRLRRIEIAT Tr_gsh-2_IIIa CLSIGTSENSHIQNGKRMRTAFTSTQLLELEREFSTNMYLSRLRRIEIAT Tn_gsh-Chr1rnd CLSIGTSENSHIQNGKRMRTAFTSTQLLELEREFSTNMYLSRLRRIEIAT Ol_gsh-2_IIIa_X YLSMGSSENSHAQNGKRMRTAFTSTQLLELEREFSTNMYLSRLRRIEIAT Dr_gsh-2_IIIa CLSLGASDNSHIQNGKRMRTAFTSTQLLELEREFSSNMYLSRLRRIEIAT Hs_gsh2 CLTMGGSDASQVPNGKRMRTAFTSTQLLELEREFSSNMYLSRLRRIEIAT Mm_gsh2 CLSMGGSDTSQVPNGKRMRTAFTSTQLLELEREFSSNMYLSRLRRIEIAT Xt_gsh2 CMTMGGAENSQAQNGKRMRTAFSSTQLLELEREFSSNMYLSRLRRIEIAT AmphiGsx PFPSGVASDGLPRDSRRMRTAFSSTQLLELEREFASNMYLSRLRRIEIAT :. . . ..:******:***********::************** Tn_gsh1_Ib YLNLSEKQVKIWFQNRRVKTKKEGKGSG-QRTG-----------SHNCKC Tr_gsh-1_Ib YLNLSEKQVKIWFQNRRVKHKKEGKGSG-QRTG-----------SHNCKC Ol_gsh-1_Ib_X YLNLSEKQVKIWFQNRRVKHKKEGKSSG-QRTG-----------SHNCKC Dr_gsh-1_Ib YLNLSEKQVKIWFQNRRVKHKKEGKSGS-HRTG-----------AHNCKC Hs_gsh1 YLNLSEKQVKIWFQNRRVKHKKEGKGSN-HRGGGGGGAGGGGSAPQGCKC Mm_gsh1 YLNLSEKQVKIWFQNRRVKHKKEGKGSN-HRGGAGAGAGGG--APQGCKC Xt_gsx-1 YLNLSEKQVKIWFQNRRVKHKKEGKSST-HRAS-----------PHGCKC Tr_gsh-2_IIIa YLNLSEKQVKIWFQNRRVKHKKEGKVT--QRS-----------AHSGCKC Tn_gsh-Chr1rnd YLNLSEKQVKIWFQNRXVKHKKEGKAT--QRQR----------AQRGASC Ol_gsh-2_IIIa_X YLNLSEKQVKIWFQNRRVKHKKEGKAT--QRS-----------AHSSCKC Dr_gsh-2_IIIa YLNLSEKQVKIWFQNRRVKHKKEGKGT--QRS-----------AHAGCKC Hs_gsh2 YLNLSEKQVKIWFQNRRVKHKKEGKGT--QRN-----------SHAGCKC Mm_gsh2 YLNLSEKQVKIWFQNRRVKHKKEGKGA--SRN-----------NHTSCKC Xt_gsh2 YLSLSEKQVKIWFQNRRVKHKKENKGS--QRN-----------THGGA-- AmphiGsx FLNLSEKQVKIWFQNRRVKHKKEARAASGSRDS--------CHCQQHRAC :*.************* ** *** : * Tn_gsh1_Ib SS-LSTVRCSEEEEDDSPVSPSSSEKEDVDLSVSP- Tr_gsh-1_Ib SS-LSTVRCSEEEEDDSPVSPSSSEKEDVDLSVSP- Ol_gsh-1_Ib_X SS-LSAARCSEEEDDDIPISPSSSEKEDVDLSVSP- Dr_gsh-1_Ib SSSLSSARCSEEE-DDLPMSPPSSEKEDADLSVSP- Hs_gsh1 AS-LSSAKCSEDD-DELPMSPSSSGKDDRDLTVTP- Mm_gsh1 SS-LSSAKCSEDD-DELPMSPSSSGKDDRDLTVTP- Xt_gsx-1 SS-LSSKCLEEDD-EDLAMSPSSSGKDDRDLSPSP- Tr_gsh-2_IIIa AT--GHTDYSRSE-DEESLSPVSAEEEKE---VSPI Tn_gsh-Chr1rnd AT--GHTDYSRSR-RHEAVSVSACQLQRKRRHVSPI Ol_gsh-2_IIIa_X AV--ALTDYSQSE-DEKSLSPASASEDKE---VSPL Dr_gsh-2_IIIa SG--SHSHYPRSE-DEESLSPVSATEEKE---TSPI Hs_gsh2 VG--SQVHYARSE-DEDSLSPASANDDKE---ISPL Mm_gsh2 VG--SQAHYARSE-DEDSLSPASANEDKE---ISPL Xt_gsh2 ------------------------------------ AmphiGsx VTRRPSGHSVTEEHAQCHSDENGQTSASTGTDVDVN