CLUSTAL X (1.81) multiple sequence alignment Xt_cdx1 MYVGYLLDKDN----NMYPNPVRHPG-------------LNLNPQNY-----VPAPPQYS Gg_HMD1 MYVGYLLDKDT----NMYPSPVRHPS-------------LNLNPQNY-----VPGPPQYS Hs_cdx1 MYVGYVLDKDS----PVYPGPARPAS-------------LGLGPANYGPPAPPPAPPQYP Dr_cdx1a MY----------------GNPARHLN-------------LSQPHLNV-----YPSAP-YP Tr_cdx-1_IVa MY---------------NSQPVRHLA-------------QALAVNSQ------YIPGPYD Tn_cdx-1_IVa_X MY---------------NSQPVRHLA-------------QALAVNSQ------YIPGPYE Ol_cdx-1_IVa_X MYP--------------NSQSVRHPA-------------QTLSLNSQ------YLPPAYD Gg_cdx2 MYVSYL-LDKDGPMYP--GPVRHSGG-------------LNLAAQNFVGA------AQYA Hs_cdx2 MYVSYL-LDKDVSMYP--SSVRHSGG-------------LNLAPQNFVSP------PQYP Xt_cad1 MYVSYL-LEKDAAMYP--GSMRAHPG-------------L----QNYPAA------PQYP Tn_cdx-2_Ib_X MYVSYLQLDKDPSMYAHQNPVTRHPG-------------LSLSPQNFAVPA----PPQYP Tr_cdx MYVSYLQLDKDPTMYPHQNAVTRHPG-------------LSLSPQNFGVPP----PPQYT Ol_cdx-2_Ib_X ------------------------------------------------------------ Dr_cdx-4_IIa_1 MYVGY---LLEKEASMYHQGAVRRSG-------------ISLPPQNFVST------PQYS Ccarp_cdx MYVGY---LLDKEGSMYHQGSVRRSG-------------ISLPPQNFVST------PQYS Tr_cdx-4_IIa MYVGY---ILDKESGMYHQGPVRRSS-------------INLPPQNFVST------PQYP Dr_cdx-4_IIa_2 MYVGY---LLEKEASMYHQGAVRRSG-------------ISLPPQNFVST------PQYS Omy_cdx MWD-----PLDKEGSMYHPGPLRRSG-------------INIPPQNFVST------PQYS Ol_cdx-4_IIa_X MYVGY---LLDKESGMYHQGPVRRSS-------------ISLPPQNFVST------QQYP Xt_cdx4 MNITCGRQAMHKDVTMYPLS-VRSAS-------------NNHSAQNYASN------QPYF Gg_cdx4 MYVSS---LLDKETSMYPGP-ARCSN-------------NNLPVQNFVPA------PPYS Hs_cdx4 MYGSC---LLEKEAGMYPGTLMSPGGDGTAGTGGTGGGGSPMPASNFAAA------PAFS AmphiCdx MYLCH--VVSDRSPSAMYRHPSQGSY--------------NLNPYNYATAH-----PAYP Xt_cdx1 DFPSYHHVP-------GINSDPHHGQPGGTWSS-YTP--------------SREDWHP-Y Gg_HMD1 DFASYHHVP-------GINNDPHHGQPAAAWGSPYTP--------------AKEDWHS-Y Hs_cdx1 DFSSYSHV------------EPAPAPP-TAWGAPFPA--------------PKDDWAAAY Dr_cdx1a DYSGYHPGP-------ALGNDLHHTGS--SWSPGFGPG-------------SRDDWPPLY Tr_cdx-1_IVa PFSGYHH-----------FPGIAEP-PASAWNSVYAP---------------REEFPFGY Tn_cdx-1_IVa_X PFSGYHH-----------FPGLADPSPAGAWNSVYAP---------------REEFPFGY Ol_cdx-1_IVa_X -FTGYHHHH-------HHVPGVIDP-TAGTWNPAYAH---------------REEYPYSF Gg_cdx2 DYGGYHV--------NLDG-AQSPGP---AWPAPYAAPLRDDWGAYGQGAPPXXXXXXXX Hs_cdx2 DYGGYHVAAAAAAAANLDS-AQSPGP---SWPAAYGAPLREDWNGYAPGGAAAAANAVAH Xt_cad1 DYGSYHG-------MGLDHGAPSSGSSA-GWITPYGPP-RDEWG-------VHPTYSPGH Tn_cdx-2_Ib_X DFAGYHHHS----INNELHPAQQAGPGGGGWNPAYPPP---------PPPPTRDEWSPHH Tr_cdx DFAGYHHHG----ISNELHPAQQAGPGSGGWNPAYPPP---------PPP-TRDEC---- Ol_cdx-2_Ib_X ------------------------------------------------------------ Dr_cdx-4_IIa_1 DFTGYHHVP----------NMETHAQSAGAWGAPYGAP--------------REDWGAYS Ccarp_cdx DFTGYHHVP----------NMDTHAQSAGAWGPPYGAP--------------REDWGAYS Tr_cdx-4_IIa DFTGYHHVP----------NMDTHAQSAGSWGSSYGAP--------------REDWGAYS Dr_cdx-4_IIa_2 DFTGYHHVP----------NMETHAQSAGAWGAPYGAP--------------REDWGAYS Omy_cdx DFTGYHHVP----------NMDTHTQSSGAWGAPYVAP--------------REDWGAYS Ol_cdx-4_IIa_X DFTGYHHVP----------NMDTHTQSASSWGPSYGGP--------------REDWGTYG Xt_cdx4 NYVTYHHVP----------PMDEQGQPCGVWGPQYGSP--------------REQWNSYG Gg_cdx4 DYMGYHHVP----------APDSHGQPAGAWGPHYGPQ--------------REDWNAYG Hs_cdx4 HYMGYPHMP----------SMDPHWPSLGVWGSPYSPP--------------REDWSVYP AmphiCdx AEYGQYQVP----PAVNAGENLQQTAAAAAWQSAAAFG-------SHGAGQRPEEWDGRG Xt_cdx1 G-PGPG----ASSAN-------------------PAQISFSPS-DYN--PVQP-PGPGLL Gg_HMD1 G-TAAA----SAATN-------------------PGQFGFSPP-DFN--PMQPHAGSGLL Hs_cdx1 G-PGPA----APAAS-------------------PASLAFGPPPDFSPVPAPPGPGPGLL Dr_cdx1a G-HGTGH---SLPAN-------------------GVEVSVLPS-----------VDQGLL Tr_cdx-1_IVa G-TGSSPSGGQVSFS-------------------SAELTVPPS----------AGGGASF Tn_cdx-1_IVa_X A-TGSSPSPGQVSFS-------------------SAELSGTPT----------ATSGGSF Ol_cdx-1_IVa_X P--GSSPSALQASFT-------------------SQELGGAPS----------PPGGGSL Gg_cdx2 X-XXXXXXXXXXXXXXXX-------------XXXXXXXXXXH-HHAGLAPQCSAGGMQPT Hs_cdx2 G-LNGGSPAAAMGYSSPA-------------DYHPHHHPHHHPHHPAAAPSCASGLLQTL Xt_cad1 T-HINPSPVGNMAFSP---------------DYSPAQVQGQP---------CVG----VL Tn_cdx-2_Ib_X Y-VAAAAADRAPGAPPPR-------------PPCPERPPEFP-----------GQSSALL Tr_cdx -------------------------------------PPEFP-----------GQPPALL Ol_cdx-2_Ib_X ------------------------------------------------------------ Dr_cdx-4_IIa_1 --LGPP-NSISAPMSNSSPGPV---------SYCSPDYNTMHGPG-----------SAVL Ccarp_cdx --LGPP-NTISAPMSSSSPGQV---------SYCSSDYNAMHGPG-----------SAVL Tr_cdx-4_IIa --LGPP-NTIPAPMSNSSPGQV---------PYCSPEYSHMHPPG-----------SAAL Dr_cdx-4_IIa_2 --LGPP-NSISAPMSNSSPGPV---------SYCSPDYNTMHGPG-----------SAVL Omy_cdx --LGPP-NTIPTPMNNSSPGQV---------SYCSPEYNPMHAPG-----------SAVL Ol_cdx-4_IIa_X --LGPP-NAIPPPMSNSSSAQG---------PYCTSEYSHMHPPG-----------ATVL Xt_cdx4 --AGPS-NTNMAQSSDLSPNQF---------AYNSSGYSSPHPSG-----------TGIL Gg_cdx4 PCPGPSGTAAAAQLSGSSPGQG---------SYSPAEYSSLHPAA-----------PGGL Hs_cdx4 ---GPSSTMGTVPVNDVTSSPA---------AFCSTDYSNLGPVGGGTSGSSLPGQAGGS AmphiCdx YNCTAGTGLTAGPTG------------------SCTAFPGMDYPVP----------VGAI Xt_cdx1 PPSLN-----SSVSPLSPSAQRRNL-YEWMRRTGVPTSTNSNGKTRTKDKYRVVYTDHQR Gg_HMD1 PPAIS-----SSVPQLSPNAQRRTP-YEWMRRS-IP-STSSSGKTRTKDKYRVVYTDHQR Hs_cdx1 AQPLG-----GPGTPSSPGAQRPTP-YEWMRRSVAAGGGGGSGKTRTKDKYRVVYTDHQR Dr_cdx1a SG--------------AP-VDREEP-QDWMRRSAVP--TNPGGKTRTKDKYRVVYSDVQR Tr_cdx-1_IVa ST--Y-----DPVSDQESFIFKKRP-QESIRPT------ASAGKTRTKDKYRVVYTDKQR Tn_cdx-1_IVa_X PT--Y-----DPP-DQDPFFFKRRP-QEPSRPT------PSAGKTRTKDKYRVVYTDRQR Ol_cdx-1_IVa_X TP--Y-----NFLCAQEPFSSRRSP--EAIRQS------ASGGKTRTKDKYRVVYTDHQR Gg_cdx2 KAPPP-PPPPPKPPPLSPGGQRRGL-CEGVRKP-AQAPLGSQVKTRTKDKYRVVYTDHQR Hs_cdx2 NPGPPGPAATAAAEQLSPGGQRRNL-CEWMRKP-AQQSLGSQVKTRTKDKYRVVYTDHQR Xt_cad1 PAGPP-----PQLSPGSEDGHRRHH-YEWLRKP-VSQAS-TGSKTRTKDKYRVVYTDQQR Tn_cdx-2_Ib_X NASAG------QLSPGSP--QRRTA-YDWIRRS-SAPPCNPNGKTRTKDKYRVVYTDHQR Tr_cdx NASAG------QLSPGSP--QRRNA-YDWIRRS-SAPPCNPNGKTRTKDKYRVVYTDHQR Ol_cdx-2_Ib_X -----------------------------------------XGKTRTKDKYRVVYTDHQR Dr_cdx-4_IIa_1 PPPPEN----IPVAQLSPERERRNS-YQWMSKTVQS---SSTGKTRTKEKYRVVYTDHQR Ccarp_cdx PPPPEN----ISVGQLSPERERRNS-YQWMSKTVQS---SSTGKTRTKEKYRVVYTDHQR Tr_cdx-4_IIa QPPPEN----VSVAQLSPDRER-LS-FQWMNKTAQS---SSTGKTRTKEKYRVVYTDHQR Dr_cdx-4_IIa_2 PPPPEN----IPVAQLSPERERRNS-YQWMSKTVQS---SSTGKTRTKEKYRVVYTDHQR Omy_cdx QPPTDN----ISVAQLSPDRERRNSSYQWMNKTVQS---SSTGKTRTKEKYRVVYTDHQR Ol_cdx-4_IIa_X QPPPDN----VSVSQLSPERERRSS-YQWMSKTAQA---SSTGKTRTKEKYRVVYTDHQR Xt_cdx4 HS-VDL----SHTAANSPSDLSQNS-YEWMGKTVQS---TSTGKTRTKEKYRVVYTDHQR Gg_cdx4 PP-AGT----VGTQQVSPTNQRHSS-YEWMRKTVPT---NTTGKTRTKEKYRVVYTDHQR Hs_cdx4 LVPTDA----GAAKASSPSRSRHSP-YAWMRKTVQ-----VTGKTRTKEKYRVVYTDHQR AmphiCdx QANSPAVSGVTTNSTNSQRPQHSRNPYDWMRKSNYS-TSPPPGKTRTKDKYRVVYSDHQR *****:******:* ** Xt_cdx1 LELEKEFHYSRYITIRRKAELAASLALTERQVKIWFQNRRAKERKVNK-KKMQQQSQQAS Gg_HMD1 LELEKEFHYSRYITIRRKAELAAALGLTERQVKIWFQNRRAKERKVNK-KKLQQQSQPTS Hs_cdx1 LELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERKVNK-KKQQQQQPPQP Dr_cdx1a LELEKEFHFSRYITIRRKAELAGTLNLSERQVKIWFQNRRAKERKMNK-KRLQQVQQSSS Tr_cdx-1_IVa MELEREFQSNRYITMRRKAELSITLGLSERQIKIWFQNRRAKERKMNR-KKLQHSQQAST Tn_cdx-1_IVa_X LELEKEFQSNRYITMRRKAELSLELGLSERXIKIWFQNRRAKERKINR-KRLQHSSPAST Ol_cdx-1_IVa_X LELEKEFQYNRYITMRRKSELSLALSLSERQVKIWFQNRRAKERKMTR-KKLQHSQQAST Gg_cdx2 LELEKEFHYSRYITIRRKAELASSLGLSERQVKIWFQNRRAKERKINK-KKLQQARR-RG Hs_cdx2 LELEKEFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAKERKINK-KKLQQQQQ-QQ Xt_cad1 LELEKEFHYSRYITIRRKAELAANLGLSERQVKIWFQNRRAKERKITK-KRIQQTQTGQN Tn_cdx-2_Ib_X LELEKEFHYSKYITIRRKSELATALSLSERQVKIWFQNRRAKERKINK-KKLQQPASSTT Tr_cdx LELEKEFHYSKYITIRRKSELATALSLSERQVKIWFQNRRAKERKINK-KKLQQPASSTT Ol_cdx-2_Ib_X LELEKEFHYSKYITIRRKAELATALSLSERQVKIWFQNRRAKERKINK-KKLQQPASSTT Dr_cdx-4_IIa_1 LELEKEFHFNRYITIRRKSELAVNLGLSERQVKIWFQNRRAKERKLIK-KKLGQSDGSGG Ccarp_cdx LELEKEFHFNRYITIRRKSELAVNLGLSERQVKIWFQNRRAKERKLIK-KKLGVSDGSGG Tr_cdx-4_IIa LELEKEFHFNRYITIRRKSELAVSLGLSERQVKIWFQNRRAKERKLIK-KKLGQSDGSGG Dr_cdx-4_IIa_2 LELEKEFHFNRYITIRRKSELAVNLGLSERQVKIWFQNRRAKERKLIK-KKLGQSDGSGG Omy_cdx LELEKEFHFNRYITIRRKSELAGNLGLSERQVKIWFQNRRAKERKLIK-KKMG-SDGSGG Ol_cdx-4_IIa_X LELEKEFHFNRYITIRRKSELAVNLGLSERQVKIWFQNRRAKERKLIK-KKLGQSDGSSG Xt_cdx4 LELEKEFHYSRYITIRRKTELAASLRLSERQVKIWFQNRRAKERKLFK-KKMNQFDGIC- Gg_cdx4 LELEKEFHCNRYITIRRKSELAANLGLSERQVKIWFQNRRAKERKIIK-KKISQFDGSGG Hs_cdx4 LELEKEFHCNRYITIQRKSELAVNLGLSERQVKIWFQNRRAKERKMIK-KKISQFENSGG AmphiCdx LELEKEFYSNKYITIKRKVQLANELGLSERQVKIWFQNRRAKQRKMAKRKELQHPGGQGG :***:** .:***::** :*: * *:** :**********:**: : *. Xt_cdx1 TTTPTP-----PSVGTTAGM-----------GGLCSSSSSN------------------S Gg_HMD1 TTTPTP-----PAVGTPGPM-----------GTLCSGSAP-------------------- Hs_cdx1 PMAHDI-----TATPAGPSL-----------GGLCPSNTS-------------------- Dr_cdx1a GLANTT-----TVSSSDS--------------GLMTDNIS-------------------- Tr_cdx-1_IVa TTPASP-----GLAEPVEAH-----------PGMSPNGFF-------------------- Tn_cdx-1_IVa_X TTLASP-----GPAGSAEAQ-----------PGMSPNGFF-------------------- Ol_cdx-1_IVa_X TTPTPP-----VLGGHTDAH-----------AAPSPSSNM-------------------- Gg_cdx2 AAQPHR--------PSASRP-----------RGPP------------------------- Hs_cdx2 PPQPPP--------PPPQPP-----------QPQPGPLRSVPEPLSPVSSLQASVSGSVP Xt_cad1 GPDTLS--------PEPSIT-----------HHMIPHATS-------------------- Tn_cdx-2_Ib_X TPTPPT--------STG--L-----------HGNSGS----------------------- Tr_cdx TPTPPA--------STGASL-----------HGNGGS----------------------- Ol_cdx-2_Ib_X TPTPPTG---NGGGTSGAGI-----------HGNGSN----------------------- Dr_cdx-4_IIa_1 SVHSDP-----GSVSPLPVR-VTESFRYTRFSVSS-TNERL------------------- Ccarp_cdx SVHSDP-----GSVSPLPVPGVTESVRHTRFSVPTPRNERL------------------- Tr_cdx-4_IIa SVHSDP-----GSVSPLPRF--SQSHGRARFSVPSPGDEPP------------------- Dr_cdx-4_IIa_2 SVHSDP-----GSVSPLPVP-----------GSLSPSDIHG------------------- Omy_cdx SVHSDP-----GSVSPLPVP-----------GSLSPSDIHG------------------- Ol_cdx-4_IIa_X SVHSDP-----GSVSPLPVP-----------GSLSPTDMHG------------------- Xt_cdx4 SVQSDS-----SSASPNPLC-----------DSVVHTDMSG------------------- Gg_cdx4 SVQSDS-----GSLSPNEIT-----------SSLFPPPHGI------------------- Hs_cdx4 SVQSDS-----DSISPGELP-----------NTFFTTPSAV------------------- AmphiCdx SDDGGGVMGEVSTLTVGPPP----HQLTLNPSGVAASTLSN------------------- Xt_cdx1 NLVSPSSMPIKEEYLS-------------------------------------------- Gg_HMD1 SLVSSSPLTIKEEFMP-------------------------------------------- Hs_cdx1 LLATSSPMPVKEEFLP-------------------------------------------- Dr_cdx1a ----SS---IKEEY---------------------------------------------- Tr_cdx-1_IVa ----SDTLS--------------------------------------------------- Tn_cdx-1_IVa_X ----SGSV---------------------------------------------------- Ol_cdx-1_IVa_X ----VSDIKSE------------------------------------------------- Gg_cdx2 ----PAG--LGPAAPQ-------------------------------------------- Hs_cdx2 GVLGPTGGVLNPTVTQ-------------------------------------------- Xt_cad1 ----NVGG-LPNTVTQ-------------------------------------------- Tn_cdx-2_Ib_X ----SVAMVTSSSSSSNGL----------------------------------------- Tr_cdx ----SVAMVTSSSGS-NGLVSPSSLPLNIKEEY--------------------------- Ol_cdx-2_Ib_X ----SVAMVTSSSGS-NGL----------------------------------------- Dr_cdx-4_IIa_1 AVHEEHTASYCHSVNSNLDHPTLTEHSNTLKGQNQ----TWSKRITNY------------ Ccarp_cdx TIYEEHTASYCHSVNSNLKDPTLTEHSNTLKGQNRSGPLAWTKRITNYYTTGIKARVVDY Tr_cdx-4_IIa PIYQEYTASDCGPVCSPLDHHNITEHSDTPTGQGQS------------------------ Dr_cdx-4_IIa_2 SLYP-AQMNALPSMR-NIQQVTVTQ----------------------------------- Omy_cdx SLYPPPGMNNLPSIR-NIQQVTVTQ----------------------------------- Ol_cdx-4_IIa_X SMYPPQGMSTLPSIR-NIQQ---------------------------------------- Xt_cdx4 SLYQPPPIALNGL----------------------------------------------- Gg_cdx4 NVLQSADIHQVIVSE--------------------------------------------- Hs_cdx4 RGFQPIEIQQVIVSE--------------------------------------------- AmphiCdx PALPPSSSPLMTSAMTHAVTLPSCVPSS-------------------------------- Xt_cdx1 ------ Gg_HMD1 ------ Hs_cdx1 ------ Dr_cdx1a ------ Tr_cdx-1_IVa ------ Tn_cdx-1_IVa_X ------ Ol_cdx-1_IVa_X ------ Gg_cdx2 ------ Hs_cdx2 ------ Xt_cad1 ------ Tn_cdx-2_Ib_X ------ Tr_cdx ------ Ol_cdx-2_Ib_X ------ Dr_cdx-4_IIa_1 ------ Ccarp_cdx HRRITS Tr_cdx-4_IIa ------ Dr_cdx-4_IIa_2 ------ Omy_cdx ------ Ol_cdx-4_IIa_X ------ Xt_cdx4 ------ Gg_cdx4 ------ Hs_cdx4 ------ AmphiCdx ------