Publications - Published papers

Please find below publications of our group. Currently, we list 496 papers. Some of the publications are in collaboration with the group of Sonja Prohaska and are also listed in the publication list for her individual group. Access to published papers (access) is restricted to our local network and chosen collaborators. If you have problems accessing electronic information, please let us know:

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Evolution of 7SK RNA and Its Protein Partners in Metazoa

Manja Marz*, Alexander Donath*, Nina Verstraete, Van Trung Nguyen, Peter F. Stadler, Olivier Bensaude

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Mol Biol Evol. 2009 Dec;26(12):2821-30.

Abstract


7SK RNA is a key player in the regulation of polymerase II transcription. 7SK RNA was considered as a highly conserved vertebrate innovation. The discovery of poorly conserved homologs in several insects and lophotrochozoans, however, implies a much earlier evolutionary origin. The mechanism of 7SK function requires interaction with the proteins HEXIM and LARP7. Here, we present a comprehensive computational analysis of these two proteins in metazoa, and we extend the collection of 7SK RNAs by several additional candidates. In particular we describe 7SK homologs in \emph{Caenorhabditis} species. Furthermore, we derive an improved secondary structure model of 7SK RNA, which shows that the structure is quite well-conserved across animal phyla despite the extreme divergence at sequence level.

Keywords


Hexim, 7SK RNA, LARP7, MePCE, Polymerase III transcription, non-coding RNA, Secondary Structure