Inst. f. Informatik   
Uni Leipzig

Bioinformatics Preprint 04-013

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Titel:
Evolution of MicroRNAs Located Within Hox Gene Clusters

Author(s):
Andrea Tanzer, Chris T. Amemiya, Chang-Bae Kim, Peter F. Stadler

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Abstract:
MicroRNAs (miRNAs) form an abundant class of non-coding RNA genes that have an important function in post-transcriptional gene regulation and in particular mod- ulate the expression of developmentally important transcription factors including Hox genes. Two families of microRNAs are genomically located in intergenic regions in the Hox clusters and vertebrates. Here we describe their evolution in detail.

Keywords:
micro RNA, mir-10, mir-196, iab-4, Hox Genes, Vertebrate Evolution

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