Inst. f. Informatik   
Uni Leipzig

Bioinformatics Preprint 04-010

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Titel:
Conserved RNA Pseudoknots

Author(s):
Caroline Thurner, Ivo L. Hofacker, Peter F. Stadler

Submitted for publication in:
GCB 2004 (Bielefeld)

Abstract:
Pseudoknots are essential for the functioning of many small RNA molecules. In addition, viral RNAs often exhibit pseudoknots that are required at various stages of the viral life-cycle. Techniques for detecting evolutionarily conserved, and hence most likely functional RNA pseudoknots, are therefore of interest. Here we present an extension of the \texttt{alidot} approach that extracts conserved secondary structures from a multiple sequence alignment and predicted secondary structures of the individual sequences. In contrast to purely phylogenetic methods, this approach yields good results already for small samples of 10 sequences or even less.

Keywords:
conserved RNA structures, pseudoknots

Alternative Numbers:


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